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| 1 | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis显示文摘AIM To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis(NASH) model influences surgical outcome.METHODS For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl_4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy(PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after PH.RESULTS In the 70% PH of NASH group, the survival rate was significantly decreased compared with that in the control and 30% PH of NASH groups(P < 0.01). 10 of 32 mice in the NASH 70% PH group died within 48 h after PH. Serum aspartate aminotransferase(AST) levels and total bilirubin(T-Bil) in the NASH 70% PH group were significantly higher than the levels in the other two groups(AST: P < 0.05, T-Bil: P < 0.01). In both PH of NASH groups, signaling proteins involved in regeneration were expressed at lower levels than those in the control group(P < 0.01). The 70% PH of NASH group also exhibited a lower number of Ki-67-positive cells and higher rates of apoptosis and necrosis than the NASH 30% PH group(P < 0.01). In addition, DNA microarray assays showed differences in gene expression associated with cell cycle arrest and apoptosis.CONCLUSION The function of the residual liver is impaired in fatty liver compared to normal liver. A larger residual volume is required to maintain liver functions in mice with NASH. | Yusuke Ozawa Takafumi Tamura Yohei Owada Yoshio Shimizu Akira Kemmochi Katsuji Hisakura Takashi Matsuzaka Hitoshi Shimano Hiroko Isoda Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，15： | 2 |
| 2 | Skipping breakfast and prevalence of overweight and obesity in Asian and Pacific regions: A meta-analysis显示文摘 | Chika Horikawa Satoru Kodama Yoko Yachi Yoriko Heianza Reiko Hirasawa Yoko Ibe Kazumi Saito Hitoshi Shimano Nobuhiro Yamada Hirohito Sone | 2011 | Preventive Medicine2011，，4： | 1 |
| 3 | SREBP-1c and TFE3, energy transcription factors that regulate hepatic insulin signaling显示文摘 | Hitoshi Shimano | 2007 | Journal of Molecular Medicine2007，，5： | 1 |
| 4 | Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes显示文摘 | Hitoshi Shimano | 2001 | Progress in Lipid Research2001，，6： | 1 |
| 5 | Sterol regulatory element-binding proteins(SREBPs):tran-scriptional regulators of lipid synthetic genes显示文摘 | Hitoshi Shimano | 2001 | Progress in Lipid Research2001，40，： | 1 |
| 6 | Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes显示文摘 | Hitoshi Shimano Naoya Yahagi Michiyo Amemiya-Kudo | 1999 | Biol Chem1999，274，35： | 1 |
| 7 | Factors influencing seedling emergence and survival inCercidiphyllum japonicum显示文摘 | Masako Kubo Hitoshi Sakio Koji Shimano Keiichi Ohno | | 0，2004，： | 1 |
| 8 | Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma显示文摘 | Kaoru Shimaya Hitoshi Shiozaki Masatoshi Inoue Hideaki Tahara Takushi Monden Takashi Shimano Takesada Mori | 1993 | Virchows Archiv A Pathological Anatomy and Histopathology1993，，4： | 1 |
| 9 | HbA 1c 5·7–6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study显示文摘 | Yoriko Heianza Shigeko Hara Yasuji Arase Kazumi Saito Kazuya Fujiwara Hiroshi Tsuji Satoru Kodama Shiun Dong Hsieh Yasumichi Mori Hitoshi Shimano Nobuhiro Yamada Kinori Kosaka Hirohito Sone | 2011 | The Lancet2011，，9786： | 1 |
| 10 | Elovl6: a new player in fatty acid metabolism and insulin sensitivity显示文摘Obesity is a major health problem in industrialized societies often associated with diabetes, insulin resistance, and hepatic steatosis. This review addresses the hypothesis that elongation of long-chain fatty acids family member 6(Elovl6) has an important role in energy metabolism and insulin sensitivity. elovl6 is a microsomal enzyme involved in the elongation of saturated and monounsaturated fatty acids with 12, 14, and 16 carbons. Mice with targeted disruption in the gene for Elovl6(elovl6^(-/-)) are resistant to diet-induced insulin resistance despite their hepatosteatosis and obesity being similar to that of the wild-type mice. Protection against diet-induced insulin resistance in Elovl6^(-/-) mice is partially due to restoration of hepatic insulin receptor substrate-2 and suppression of hepatic protein kinase C ?, resulting in restoration of Akt phosphorylation. We suggest that inhibition of this elongase could be a new therapeutic approach for the treatment of insulin resistance, diabetes,cardiovascular disease, and other metabolic diseases. | Takashi Matsuzaka Hitoshi Shimano | 2016 | 世界最新医学信息文摘2016，16，11： | 0 |
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