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| 1 | “Wait and scan” management of patients with vestibular schwannoma and the relevance of non-contrast MRI in the follow-up显示文摘Vestibular schwannoma(VS) is a slow-growing benign neoplasm. There has been an evolution in the management of VS from active treatments(microsurgery and stereotactic radiotherapy) to conservative management(wait and scan). Regular MRI scanning is necessary to monitor tumor progression. Conservative management causes significantly less complications and offers a higher quality of life compared with active treatments. The mean growth rate of VS varies from 0.4 to 2.9 mm/year, and spontaneous shrinkage is observed in 3.8 percent of tumors during observation. If significant growth occurs, active treatment is considered. Significant growth is defined as an increase of at least 3 mm in the largest extrameatal diameter in any plane between the first and last available scans. The vestibulocochlear nerve is surrounded by cerebrospinal fluid, which provides natural contrast for MRI; thus, gadolinium may not be needed to detect VS. Specific sequences have high sensitivity, specificity, and accuracy for detection of progression. Hypointense signal in the ipsilateral inner ear fluid might be a useful sign to distinguish VS from meningioma. In this paper, we summarize the current status of research on conservative management and non-contrast MRI for the detection of VS. | Jing Zou Timo Hirvonen | 2017 | Journal of Otology2017，12，4： | 5 |
| 2 | Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy显示文摘Objective:The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy(CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Materials and methods:Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy,two-photon excited fluorescence(TPEF) microscopy,and the second harmonic generation(SHG) microscopy.Results:In cholesteatoma tissues from the mastoid,a strong resonant signal at 2845 cm^(-1) was observed by CARS,which indicated the detection of the CH_2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm^(-1) suggestive of CH_3 bonds in amino acids.A strong resonant signal at 2940 cm^(-1) appeared in an area of the same specimen,which also generated abundant signals by TPEF and SHG microscopy at 817 nm,which was suggestive of collagen.In the tympanic membrane specimen with cholesteatoma,a strong resonant signal with corrugated morphology was detected,which indicated the presence of lipids.A strong signal was detected in the tympanic membrane with chronic otitis media using TPEF/SHG at 817 nm,which indicated collagen enrichment.The CARS and TPEF/SHG images were in accordance with the histology results.Conclusion:These results suggest the need to develop a novel CARS microendoscope that can be used in combination with TPEF/SHG to distinguish cholesteatoma from inflammatory tissues. | Jing Zou Antti Isomaki Timo Hirvonen Antti Aarnisalo Jussi Jero Ilmari Pyykko | 2016 | Journal of Otology2016，11，3： | 4 |
| 3 | Controlled deposition of electrospun poly(ethylene oxide) fibers显示文摘 | J.M. Deitzel J.D. Kleinmeyer J.K. Hirvonen N.C. Beck Tan | 2001 | Polymer2001，，19： | 3 |
| 4 | A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors显示文摘经由 nanoparticulate 系统的联合治疗已经为癌症治疗作为一条 synergistic 途径被建议了。此处, undecylenic 酸热地修改了多孔的硅 nanoparticles (UnTHCPSi NP ) 与 sorafenib 装载了的 hydrocarbonized,有 anti-CD326 抗体(Ab ) 的 surface-biofunctionalized 在 MCF-7 和 MDA-MB-231 乳癌房间为癌症 chemo 免疫疗法被开发。cytocompatibility 学习没在比 200 g 低的集中为赤裸、结合抗体的 UnTHCPSi (Un-Ab ) NP 显示出重要毒性 ? 浩汰楹杮愠搠 ' 糖锚?湩琠敨漠潸桰汩捩瑩 ? 景琠敨猠牵慦散倠 ? 瑡浯吗? | Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia Tomas Ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos | 2015 | Nano Research2015，8，5： | 2 |
| 5 | Effect of nitrogen ion-implantation on the tribological properties and hardness of TiN films显示文摘 | R.R. Manory C.L. Li C. Fountzoulas J.D. Demaree J.K. Hirvonen R. Nowak | 1998 | Materials Science & Engineering A1998，，1： | 2 |
| 6 | Application of neural network in suppressing mechanical vibration of a permanent magnet linear motor 显示文摘 | Hassan Yousefi Markus Hirvonen Heikki Handroos | 2008 | Control Engineering Practice (S0967-0661)2008，16，7： | 1 |
| 7 | Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis 显示文摘 | Penttil M J skel inen E Hirvonen N | 2014 | The British Journal of Psychiatry2014，205，2： | 1 |
| 8 | The adverse hemodynamic effects of anesthesia, head-up tilt,and carbon dioxide pneumoperitoneum during laparoscopic cholecystectomy 显示文摘 | HIRVONEN EA POIKOLAINEN EO PAAKKONEN ME | 2000 | Surg Endosc2000，14，3： | 1 |
| 9 | The human CYP2E1 gene and lung cancer:Dra I and Rsa 1 restriction fragment length polymorphisms in a Finnish study显示文摘 | Hirvonen A Husgafvel-Pursiainen K Anttila S | 1993 | Carcinogenesis1993，14，： | 1 |
| 10 | Intake of flavonols and flavones and risk of coronary heart disease in male smokers显示文摘 | Hirvonen T Pietmen P Virtanen M | 2001 | Epidemiology2001，12，1： | 1 |
| 11 | Ventilatony effects,blood gas changes and oxygen cousumption during laparoscopic hysteretomy显示文摘 | Hirvonen EA Nuutinen LS Kauko M | 1995 | Anesth Analg1995，80，5： | 1 |
| 12 | Antidepressant mechanism of add--on repetitive transcranial magnetic stimulation in medication resistant depression using cerebral glucose metabolism显示文摘 | ILl C T Wang S J Hirvonen J et aI | 2010 | J Affect Disord2010，127，13： | 1 |
| 13 | Stim- ulated cytokines production correlates in umbilical arte- rial and venous blood at delivery 显示文摘 | Keski-Nisula L Roponen M Hirvonen M R | 2004 | European Cyto- kine Network2004，15，4： | 1 |
| 14 | Antigens Duffy, Kidd, Lutheran and Xga on fetal red cells显示文摘 | Toivanen P Hirvonen T | 1973 | Vox Sang1973，24，4： | 1 |
| 15 | Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region显示文摘 | Ton CC Hirvonen H Miwa H | | 0，，： | 1 |
| 16 | The effect of xylitol on the composition of the oral flora:a pilot study显示文摘 | Soderling E Hirvonen A Karjalainen S | 2011 | Eur J Dent2011，5，1： | 1 |
| 17 | Positional cloning and characterization of a paired box and homeobox-containing gene from the aniridia region 显示文摘 | Ton CC Hirvonen H Miwa H | 1991 | Ce111991，67，6： | 1 |
| 18 | The benefits of increasing the number of microsatellites uti- lized in genetic population studies:an empirical per- spective显示文摘 | Koskinen M T Hirvonen H Landry P A | 2004 | Hereditas2004，141，1： | 1 |
| 19 | Human umbilical cord blood- derived mesenchymal stromal cells display a novel interaction between P-Selectin and gateetin-1 显示文摘 | Suila H Hirvonen T Kotovuori A | 2014 | Seand J lmmuno12014，80，： | 1 |
| 20 | 芬兰人工耳蜗植入术加强无菌措施的方法显示文摘人工耳蜗植入已经在全球广泛开展并帮助广大聋病患者重新返回正常生活,且并发症的发生率也越来越少;然而,围手术期和术后晚期感染性并发症仍然时有发生。在某些特殊病例中,当抗生素无效时,植入体也将会被废弃,重新植入将会显著增加患者经济负担。芬兰的所有人工耳蜗植入中心都采用一种术中加强无菌措施以便预防或者减少感染性并发症的发生。其关键点是,从手术室的术前准备到完成植入手术,全程严格实施无菌操作,在完成颞骨钻磨工作以后,清理术野,医生和护士重新进行手部消毒,更新术区的无菌巾和医护人员的手套,打开人工耳蜗植入体的包装,固定植入体并安装耳蜗电极,完成后续程序。在仅预防性使用抗生素的情况下,610次人工耳蜗植入未发生植入体的原发性感染并发症。邹静于2016年在赫尔辛基大学中心医院耳鼻咽喉头颈外科学习人工耳蜗植入的临床相关技术,将这一加强无菌措施在长海医院推广应用。除了因为医院的实际情况而存在一些较小的差异外,关键步骤完全可以在长海医院实施。本文将对该技术进行详细报道,期望今后在中国全国推广这一效价比很高的技术。 | 邹静 秦晶 姜晓瑜 李勇 周蓉珏 徐菲 Timo Hirvonen Antti Aarnisalo Jussi Jero 郑宏良 | 2018 | 中华耳科学杂志2018，16，1： | 1 |
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