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| 1 | Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping显示文摘AIM: To identify chromosomal translocations specific to gastric cancer (GC), spectral karyotyping (SKY) analysis was performed on established cell lines and cancerous ascitic fluids.METHODS: SKY analysis of 10 established cell lines and seven cancerous ascitic fluid samples identified recurrent chromosomal breakpoints and translocations in GC,several of which involved chromosomal loci of oncogenes or tumor suppressor genes.RESULTS: A total of 630 chromosomal breaks were identified. Chromosome no.8 was the most frequently involved in rearrangements (65 breaks), followed by chromosomes no. 11 (53), no. 1 (49), no. 7 (46), no. 13 (37), no. 3 (36), no. 17 (33), and no. 20 (29). Frequent breakpoints were detected in 8q24.1 (30 breaks), 11q13 (29), 13q14 (16), 20q11.2 (14), 7q32 (13), 17q11.2 (13),18q21 (12), 17q23 (9), 18q11.2 (9). SKY analysis identified a total of 242 chromosomal rearrangements including 190 reciprocal and non-reciprocal translocations. The recurrent combinations of chromosomal bands involved in translocations were 8q24.1 and 13q14 (3 cases), 8q24.1 and 11q13 (3), 11q13 and 17q11.2 (2), and 18q11.2 and 20q11.2 (2). Our study validated the ability of SKY to characterize in detail the chromosomal rearrangements in solid tumors and derived cell lines. Moreover,fluorescence in situ hybridization helped to identify the insertions, translocations, and homogeneously staining regions of MYCand CCND1 gene loci.CONCLUSION: The non-random co-localization of certain cytogenetic bands suggests the importance of chromosomal translocations in gastric carcinogenesis, by serving as landmarks for the cloning of GC causing genes. | Yasuhide Yamashita Kazuhiro Nishida Takashi Okuda Kenichi Nomura Yosuke Matsumoto Shoji Mitsufuji Shigeo Horiike Hiroyuki Hata Chohei Sakakura Akio Hagiwara Hisakazu Yamagishi Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 2 | Submucosal hematoma 是一高度暗示的作出对 \O 有利的裁决淀粉的轻链的淀粉样变性病: 二份案例报告显示文摘 The clinical and endoscopic features of amyloid lightchain(AL) amyloidosis are diverse and mimic various other diseases.Endoscopically,few reports on submucosal hematomas of the gastrointestinal(GI) tract are available in the literature.Here,we report two cases of AL amyloidosis presenting as submucosal hematomas in the absence of clinical disease elsewhere in the body.The 2 cases were referred to our hospital because of hematochezia.The endoscopic findings in both cases were similar in submucosal hematoma formation.However,the clinical courses differed.In the first case,there was no evidence of systemic amyloidosis and the disease was conservatively managed.In the second case,the disease progressed to systemic amyloidosis and the patient died within a short time.We conclude that the endoscopic detection of a submucosal hematoma in the setting of GI bleeding should raise suspicion of AL amyloidosis.Referral to a hematologist should be done immediately for treatment while the involvement is limited to the GI tract. | Shinji Yoshii Katsuhiro Mabe Katsuhiko Nosho Hiroyuki Yamamoto Hiroshi Yasui Hiroyuki Okuda Akira Suzuki Masahiro Fujita Toshihiro Sato | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 2 |
| 3 | Performance of Ballasted Ladder Track under Heavy Axle Loads Tested at TTCI显示文摘 | Kiyoshi ASANUMA Nobuyuki MATSUMOTO Hiroyuki OKUDA Hajime WAKUI | 2002 | RTRI Report2002，16，2： | 1 |
| 4 | Predictors of Left Main or Three-Vessel Disease in Patients Who Have Acute Coronary Syndromes With Non–ST-Segment Elevation显示文摘 | Masami Kosuge Kazuo Kimura Toshiyuki Ishikawa Toshiaki Ebina Tomoaki Shimizu Kiyoshi Hibi Noritaka Toda Yoshio Tahara Kengo Tsukahara Masahiko Kanna Jyunn Okuda Naoki Nozawa Hiroyuki Ozaki Hideto Yano Satoshi Umemura | 2005 | The American Journal of Cardiology2005，，11： | 1 |
| 5 | Combined Prognostic Utility of ST Segment in Lead aVR and Troponin T on Admission in Non–ST-Segment Elevation Acute Coronary Syndromes显示文摘 | Masami Kosuge Kazuo Kimura Toshiyuki Ishikawa Toshiaki Ebina Kiyoshi Hibi Kengo Tsukahara Masahiko Kanna Noriaki Iwahashi Jyun Okuda Naoki Nozawa Hiroyuki Ozaki Hideto Yano Ikuyoshi Kusama Satoshi Umemura | 2006 | The American Journal of Cardiology2006，，3： | 1 |
| 6 | Evaluation of the IS process featuring membrane techniques by total thermal efficiency 显示文摘 | Nomura Mikihiro Kasahara Seiji Okuda Hiroyuki | 2005 | Int J Hydrogen Energy2005，30，： | 1 |
| 7 | Predictors of Left Main or Three-Vessel Disease in Patients Who Have Acute Coronary Syndromes With Non–ST-Segment Elevation显示文摘 | Masami Kosuge Kazuo Kimura Toshiyuki Ishikawa Toshiaki Ebina Tomoaki Shimizu Kiyoshi Hibi Noritaka Toda Yoshio Tahara Kengo Tsukahara Masahiko Kanna Jyunn Okuda Naoki Nozawa Hiroyuki Ozaki Hideto Yano Satoshi Umemura | 2005 | The American Journal of Cardiology2005，，11： | 1 |
| 8 | Structure of grapevine stilbene synthase genes,inducing difenet amounts of resveratrol under Elicitor treatment显示文摘 | Hiroyuki Ohashi Tsutomu Takayanagi Tohru Okuda et a1 | 2001 | Am J Erol Vitic2001，52，3： | 1 |
| 9 | Lamina Horizontalization and Facet Tropism as the Risk Factors for Adjacent Segment Degeneration After PLIF显示文摘 | Shinya Okuda Takenori Oda Akira Miyauchi Satoru Tamura Yoshichika Hashimoto Shinya Yamasaki Takamitsu Haku Fumiaki Kanematsu Kenta Ariga Tetsuo Ohwada Hiroyuki Aono Noboru Hosono Takeshi Fuji Motoki Iwasaki | 2008 | Spine2008，，25： | 1 |
| 10 | Nucleotide Sequence of Citrus Tristeza Virus Seedling Yellows Isolate显示文摘 | Cede SUASTIKA Tomohide NATSUAKI Hirotsugu TERUI Takeshi KANO Hiroyuki IEKI Seiichi OKUDA | 2001 | Journal of General Plant Pathology2001，，1： | 1 |
| 11 | Structure of grapevine stilbene synthase genes,inducing diffenet amounts of resveratrol under Elicitor treatment显示文摘 | Tsutomu Takayanagi Tohru Okuda | 2001 | Am j Erol Vitic2001，52，3： | 1 |
| 12 | An Experimental Study on Slotting of Inconel 718 Thin Sheet显示文摘 | Hiroyuki Kodama Koichi Okuda Tomoya Hayase | 2015 | Journal of Mechanics Engineering and Automation2015，5，11： | 0 |
| 13 | D—SPECT和γ照相机^123I-MIBG显像心脏与纵隔放射性比值的交叉校正显示文摘【摘要】目的心脏^123I-间位碘代苄胍(^123I-MIBG)的摄取可通过核素显像计算心脏与纵隔放射性比值(HMR)进行定量。使用具有碲-锌-镉固态探测器的心脏专用SPECT(D—SPECT)和普通γ照相机均可获得HMR,但两者间的关系尚未完全明确。 | 唐军 Kenichi Nakafima Koichi Okuda Kunihiko Yokoyama Tatsuya Yoneyama Shiro Tsuji Hiroyuki Oda Mitsuhiro Yoshita Koji Kubota | 2018 | 中华核医学与分子影像杂志2018，38，4： | 0 |
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