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| 1 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 2 | Damage to Daikai subway station显示文摘 | IIDA H HIROTO T YOSHIDA N IWAFUJI M | 1996 | Soils and Foundations1996，，： | 1 |
| 3 | EX- AFS study of (Lal M)2Zr207 (M=Nd and Ce)显示文摘 | HIROTO Y YUJI A TSUNEO M | 1996 | Materials1996，238，2： | 1 |
| 4 | Advanced Method for Measuring Proteinase A in Beer显示文摘 | Yomo Hideko Furuhlbo Su m | | Proceedings-25th Convention of the Institute of Brewing-ASIA Pacific Section0，1998，： | 1 |
| 5 | Loop-mediated isothermal amplification of DNA 显示文摘 | NOTOMI T HIROTO O HARUMI M | 2000 | Nucleic Acids Reaearch2000，28，12： | 1 |
| 6 | IL-6/IL-6 receptor system and its role in physiological and pathological condi- tions 显示文摘 | Masahiko M Misato H Hiroto Y et aZ | 2012 | Clin Sci2012，122，： | 1 |
| 7 | Active vibration control system using a gyro-stabilizer显示文摘 | YAMADA M HIROTO H NAMIKI M | 1997 | Control Engineering and Practice1997，5，9： | 1 |
| 8 | Pegylalion of proteins and bioactive substances for medical and technical applications显示文摘 | Koclcra Y Matsushima A Hiroto M | 1998 | Prog Polym Sci1998，23，： | 1 |
| 9 | Pegylation of proteins and bioactive substances for medical and technical applications 显示文摘 | Kdera Y Matsuchima A Hiroto M | 1998 | Prog Polymer Sci1998，23，： | 1 |
| 10 | Evidence - based clinical practice guidelines for functional dyspepsia 显示文摘 | Hiroto M Motoyasu K Tomiyasu A | 2015 | Journal of Gastroen- terology2015，50，2： | 1 |
| 11 | Elevation of rat plasma P-selectin in acute lung injury 显示文摘 | Mayumi H Toshiyuki M Hiroto K | 2007 | Biochim Biophys Acta2007，1772，3： | 1 |
| 12 | Evidence - based clinical practice guidelines for functional dyspepsia 显示文摘 | Hiroto M Motoyasu K Tomiyasu A | 2015 | Journal of Gastroen- terology2015，50，2： | 1 |
| 13 | Pegylation of proteins and bioactive substances for medical and technical applications 显示文摘 | Kodera Y Matsushima A Hiroto M | 1998 | Prog Polymer Sci1998，23，7： | 1 |
| 14 | Regulation of proteins and bioactive substances for medical and technical application显示文摘 | Kodera Y Matsushima A Hiroto M | 1998 | J Prog polymer Sci1998，23，： | 1 |
| 15 | Controlled cationic ring-opening polymerization of 1,3-oxazoli- dine-2-thione derived from L-serine 显示文摘 | Atsushi N Toyoharu M Hiroto K | 2003 | Macromole- cules2003，36，： | 1 |
| 16 | Model specification search using ggenetic algorithm for factor analysis model 显示文摘 | HIROTO M | 2008 | Japanese Psychological Research2008，49，3： | 1 |
| 17 | A novel representation of protein sequences for prediction of subcellular location using support vector machines显示文摘 | Setsuro M Jean-Philippe V Hiroto S | 2005 | Protein Sci2005，14，11： | 1 |
| 18 | Expression of Survivin is correlated with cancer cell apoptosis and is involved in the development of human pancreatic duct cell tumors显示文摘 | Satoh K Kaneko K Hiroto M | 2001 | Cancer2001，92，2： | 1 |
| 19 | Interleukin-17 gene expression in patients wilh thetmaatoid arlhdfis显示文摘 | Mika K Akito T Hiroto M | 2008 | Mod Rhetanatol2008，18，1： | 1 |
| 20 | Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K+channels 显示文摘 | Hiroto M Yanping L | 2000 | Heart circul physiol2000，279，6： | 1 |
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