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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | Antidiabetic activities of chalcones isolated from a Japanese Herb,Angelica keiskei显示文摘 | TATSUJI E HIROMU O KINUKO N | | 0，，55： | 1 |
| 3 | Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica Keiskei 显示文摘 | TATSUJI E HIROMU O KINUKO N | 2007 | Agric Food Chem2007，55，： | 1 |
| 4 | Angelica keiskei extract improves insulin resistance and hypertriglyceridemia in rats fed a high-fructose drink 显示文摘 | HIROMU O SHOKO H YOKO K | 2012 | Biosci Biotechnol Bioehem2012，76，5： | 1 |
| 5 | Development of manufacturing technology for high alloy steel seamless pipe by mannesmann process显示文摘 | Nobuhiko M Hiromu O Tetsuo S | 1998 | Kawasaki Steel Technical Report1998，38，： | 1 |
| 6 | 显示文摘 | KAZUHIKO O HIROMU K MAKOTO S | 1984 | Journal of the Japan Petroleum Institute1984，27，4： | 1 |
| 7 | Lunar Radar Sounder Observations of Subsurface Layers Under the Nearside Maria of the Moon 显示文摘 | Takayuki O Kumamoto A Hiromu N | 2009 | Science2009，323，： | 1 |
| 8 | Generation of active oxygen species from advanced glycation end-products (AGE)under ultraviolet lightA (UVA)irriadiation显示文摘 | Hitoshi M Yuri O Hiromu S | 1997 | Biochem Biophys Res Com1997，235，： | 1 |
| 9 | Anatomic variations of the cer ebral arteries and their embryology:a pictorial review显示文摘 | Mika O Hiro K Hiromu M | 2002 | Eur Ra- diol2002，12，25： | 1 |
| 10 | Lunar radar sounder observations of subsurface layers under the nearside maria of the Moon显示文摘 | Takayuki O Atsushi K Hiromu N | 2009 | Science2009，323，： | 1 |
| 11 | Effect of substituent groups on the glucosyl conjugation of xenobiotic phenols by cultured cells of Gardenia jasminoids显示文摘 | HAJIME M ATSUKO H HIROMU O | 1987 | Plant Science1987，48，： | 1 |
| 12 | Antidiabetic activities of chalcones isolated from a Japanese herb, Angelica keiskei 显示文摘 | Tatsuji E Hiromu O Kinuko N | 2007 | JAgricFoodChem2007，55，15： | 1 |
| 13 | Comparison of statistical process monitoring methods:application to the Eastman challenge problem显示文摘 | Manabu K Koji N Shinji H Iori H Hiromu O Ramon S Bhavik B | 2000 | Computers and Chemical Engineering2000，24，： | 1 |
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