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| 1 | Glucose metabolism in gastric cancer:The cutting-edge显示文摘Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis(Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer. | Lian-Wen Yuan Hiroharu Yamashita Yasuyuki Seto | 2016 | World Journal of Gastroenterology2016，22，6： | 18 |
| 2 | Helicobacter pylori infection in subjects negative for high titer serum antibody显示文摘AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori(H. pylori) antibody.METHODS The antibody titers were measured using antigens derived from Japanese individuals. ^(13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness.RESULTS Of the 136 subjects enrolled, 23(17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve(0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10^(-20)) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies(89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate analysis.CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients. | Osamu Toyoshima Toshihiro Nishizawa Masahide Arita Yosuke Kataoka Kosuke Sakitani Shuntaro Yoshida Hiroharu Yamashita Keisuke Hata Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，13： | 9 |
| 3 | Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique显示文摘 | Takashi Mitsui Keiko Niimi Hiroharu Yamashita Osamu Goto Susumu Aikou Fumihiko Hatao Ikuo Wada Nobuyuki Shimizu Mitsuhiro Fujishiro Kazuhiko Koike Yasuyuki Seto | 2014 | Gastric Cancer2014，，3： | 5 |
| 4 | Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells显示文摘AIM: To examine whether lysophosphatidic acid (LPA)induces phosphorylation of c-Met and epidermal growth factor receptor (EGFR), both of which have been proposed as prognostic markers of colorectal cancer, and whether LPA induces cyclooxygenase-2 (COX-2) expression in human colon cancer cells.METHODS: Using a human colon cancer cell line, LoVo cells, we performed immunoprecipitation analysis,followed by Western blot analysis. We also examined whether LPA induced COX-2 expression, by Western blot analysis.RESULTS: Immunoprecipitation analysis revealed that 10 μmol/L LPA induced tyrosine phosphorylation of c-Met and EGFR in LoVo cells within a few minutes. We found that c-Met tyrosine phosphorylation induced by LPA was not attenuated by pertussis toxin or a matrix metalloproteinase inhibitor, in marked contrast to the results for EGFR. In addition, 0.2-40 μmol/L LPA induced COX-2 expression in a dose-dependent manner.CONCLUSION: Our results suggest that LPA acts upstream of various receptor tyrosine kinases (RTKs) and COX-2,and thus may act as a potent stimulator of colorectal cancer. | Joji Kitayama Hironori Yamaguchi Hiroharu Yamashita Ken Mori Toshiaki Watanabe Hirokazu Nagawa | 2005 | World Journal of Gastroenterology2005，11，36： | 5 |
| 5 | Salvage Gastrectomy After Intravenous and Intraperitoneal Paclitaxel (PTX) Administration with Oral S-1 for Peritoneal Dissemination of Advanced Gastric Cancer with Malignant Ascites显示文摘 | Joji Kitayama Hironori Ishigami Hironori Yamaguchi Hiroharu Yamashita Shigenobu Emoto Shoich Kaisaki Toshiaki Watanabe | 2014 | Annals of Surgical Oncology2014，，2： | 2 |
| 6 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 7 | Effect of Preoperative Hyperfibrinogenemia on Recurrence of Colorectal Cancer Without a Systemic Inflammatory Response显示文摘 | Hiroharu Yamashita Joji Kitayama Masataka Taguri Hirokazu Nagawa | 2009 | World Journal of Surgery2009，，6： | 2 |
| 8 | Clinical significance of CA125 and CA72-4 in gastric cancer with peritoneal dissemination显示文摘 | Shigenobu Emoto Hironori Ishigami Hiroharu Yamashita Hironori Yamaguchi Shoichi Kaisaki Joji Kitayama | 2012 | Gastric Cancer2012，，2： | 2 |
| 9 | A new resin system for super high solids coating显示文摘 | HISAKI TANNBE HIROHARU OHSUJI | 1997 | Progress in Organic Coatings1997，32，： | 1 |
| 10 | A Combined Subtemporal and Transventricular/Transchoroidal Fissure Approach to Medial Temporal Lesions显示文摘 | Susumu Miyamoto Hiroharu Kataoka Akio Ikeda Jun Takahashi Nobuhiro Mikuni Keiko Usui Motohiro Takayama Takeshi Satow Nobuo Hashimoto | 2004 | Neurosurgery2004，，5： | 1 |
| 11 | Research on Wet Steam Spontaneous Condensing Flows Considering Phase Transition and Slip显示文摘A new dual-fluid model considering phase transition and velocity slip was proposed in this paper and the Cunningham correction was used in the droplet resistance calculation. This dual-fluid model was applied to the numerical simulations of wet steam flow in a 2D LAVAL nozzle and in the White cascade respectively. The results of two simulations demonstrate that the model is reliable. Meanwhile, the spontaneous condensing flow in White cascade was analyzed and it infers that the irreversible loss caused by condensation accounts for the largest share (about 8.78% of inlet total pressure) in total pressure loss while the loss caused by velocity slip takes the smallest share (nearly 0.42%), and another part of total pressure loss caused by pneumatic factors contributes a less share than condensation, i.e. almost 3.95% of inlet total pressure. | Ke CUI Huan-long CHEN Yan-ping SONG Hiroharu OYAMA | 2013 | Journal of Thermal Science2013，22，4： | 1 |
| 12 | Raman scattering spectra ofCdS microcrystallites in silicate glasses显示文摘 | Takayuki Komatsu Hiroharu Mohri Masaaki Ohno | 1992 | J Mater Sci Lett1992，11，： | 1 |
| 13 | Oxidized LDL modulates Bax/Bcl-2 through the lectinlike ox-LDL receptor-1 in vascular smooth muscle cell显示文摘 | Hiroharu K Noriaki K Susumu M Manabu M Masafumi M Kazutaka H | 2001 | Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 14 | Arabidopsis ENHANCER OF SHOOT REGENERATION ( ESR ) 1 and ESR2 regulate in vitro shoot regeneration and their expressions are differentially regulated显示文摘 | Naoki Matsuo Miho Makino Hiroharu Banno | 2011 | Plant Science2011，，1： | 1 |
| 15 | NF-κB is a key mediator of cerebral aneurysm formation显示文摘 | Tomohiro A Hiroharu K Munehisa S | 2007 | Circulation2007，116，： | 1 |
| 16 | A new resin system for super high solids coating 显示文摘 | Hisaki Tanabe Hiroharu Ohsuii | 1997 | Progress in Organic Coatings1997，，32： | 1 |
| 17 | The Arabidopsis transcription factor ESR1 induces in vitro shoot regeneration through transcriptional activation显示文摘 | Naoki Matsuo Hiroharu Banno | 2008 | Plant Physiology and Biochemistry2008，，12： | 1 |
| 18 | Endobronchial leiomyoma: Report of a case treated by bronchoplasty and a review of the literature显示文摘 | Hiroyoshi Ayabe Hiroharu Tsuji Yutaka Tagawa Masao Tomita Nobuo Tsuda Jiann-I Chen | 1995 | Surgery Today1995，，12： | 1 |
| 19 | Direct observation of dynamic molecular behavior at a waternitrobenzene interface in a chemical oscillation system显示文摘 | Tetsuya T Hiroharu Y Tsaguo S | 2002 | J Phys Chem B2002，106，： | 1 |
| 20 | Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice显示文摘 | Dong Yang Yukako Nakajo Koji Iihara Hiroharu Kataoka Hiroji Yanamoto | 2013 | Brain Research2013，，： | 1 |
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