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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | An internal model control strategy for nonlinear systems显示文摘 | SEBORG D E | 1991 | AIChE J1991，37，： | 1 |
| 3 | The acuteimmune response to exhaustive resistance exercise显示文摘 | Nieman D C Henson D A Sempeon C S | 1995 | Int Jsports med1995，16，： | 1 |
| 4 | The small footprint waste-water treatment process显示文摘 | STEP HENSON T MAN A UPTON J | 1993 | Chemistry & Industry1993，19，： | 1 |
| 5 | Nonlinear model predictive control: current status and future directions 显示文摘 | Henson Michael A | 1998 | Computersa & Chemical Engineering1998，23，2： | 1 |
| 6 | Male and female alternative reproductive behaviors in fishes: a new approach using intersexual dynamies显示文摘 | HENSON S A WARNER R R | 1997 | Annual Review of Ecology and Systematics1997，28，： | 1 |
| 7 | Selection of model parameters for off-line parameter estimation显示文摘 | Li R Henson M A Kurtz M J | 2004 | 1EEE Trans on Control Systems Technology2004，12，3： | 1 |
| 8 | An internal model control strategy for nonlinear systems显示文摘 | HENSON M A SEBORG D E | 1991 | America Institute of Chemical Engineering Journal1991，37，7： | 1 |
| 9 | Evaluation of Heated Solutions of Sulfur Dioxide, Ethanol, and Hydrogen Peroxide to Control Postharvest Green Mold of Lemons 显示文摘 | SMILANICK J L MARGOSAN D A HENSON D J | 1995 | Plant Dis1995，，79： | 1 |
| 10 | Feedback linearizing control of discrete-time nonlinear systems with input constraints 显示文摘 | KURTZ M J HENSON M A | 1998 | Interna- tional Journal of Control1998，70，4： | 1 |
| 11 | Food Safety Regulation: An Overview of Contemporary Issues显示文摘 | HENSON SPENCER CASWELL JULIE A | 1999 | Food Policy1999，，24： | 1 |
| 12 | Pathogenic properties of fungal melanins显示文摘 | Butler M J Day A W Henson J M | 2001 | Mycologia2001，93，： | 1 |
| 13 | Nonlinear model predictive control: Current Status and future directions显示文摘 | Henson M A | 1998 | Computers and Chemical Engineering1998，23，2： | 1 |
| 14 | Nonlinear model predictive control: current status and future directions 显示文摘 | HENSON M A MICHAEL A | 1998 | Computer and Chemical Engineering1998，23，2： | 1 |
| 15 | Scopolamine but not lorazepam modulates face repetition priming: A psychopharmacological fMR1 study显示文摘 | Thiel C M Henson R N A Dolan R J | 2002 | Neuropsychopharmacology2002，27，2： | 1 |
| 16 | Nonlinear State Estimation and Model Predictive Control of Nitrogen Purification Columns 显示文摘 | BIAN S HENSON M A BELANGER P | 2005 | Industrial and Engineering Chemistry Research2005，44，1： | 1 |
| 17 | The effect of soil sample handling between collection and drying on nitrate concentration显示文摘 | Westfall D G Henson M A Evans E P | 1978 | Communications in Soil Science and Plant Analysis1978，9，2： | 1 |
| 18 | Gastrointestinal symp- toms after pelvic radiotherapy:a national survey of gastroenterolo- gists显示文摘 | Henson C C Davidson S E Lalji A | 2012 | Support Care Cancer2012，20，9： | 1 |
| 19 | Moisture diffusion in the cured hurley tobacco leaf 显示文摘 | Walton L R Henry Z A Henson W H | 1976 | Transactions of the ASA- BE1976，19，4： | 1 |
| 20 | Translational evidence that impaired autophagy contributes to arterial ageing 显示文摘 | LaRocca TJ Henson GD Thorburn A | 2012 | J Physiol2012，590，14： | 1 |
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