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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | An internal model control strategy for nonlinear systems显示文摘 | SEBORG D E | 1991 | AIChE J1991，37，： | 1 |
| 3 | Selection of model parameters for off-line parameter estimation显示文摘 | Li R Henson M A Kurtz M J | 2004 | 1EEE Trans on Control Systems Technology2004，12，3： | 1 |
| 4 | An internal model control strategy for nonlinear systems显示文摘 | HENSON M A SEBORG D E | 1991 | America Institute of Chemical Engineering Journal1991，37，7： | 1 |
| 5 | Feedback linearizing control of discrete-time nonlinear systems with input constraints 显示文摘 | KURTZ M J HENSON M A | 1998 | Interna- tional Journal of Control1998，70，4： | 1 |
| 6 | Pathogenic properties of fungal melanins显示文摘 | Butler M J Day A W Henson J M | 2001 | Mycologia2001，93，： | 1 |
| 7 | Nonlinear model predictive control: Current Status and future directions显示文摘 | Henson M A | 1998 | Computers and Chemical Engineering1998，23，2： | 1 |
| 8 | Nonlinear model predictive control: current status and future directions 显示文摘 | HENSON M A MICHAEL A | 1998 | Computer and Chemical Engineering1998，23，2： | 1 |
| 9 | Scopolamine but not lorazepam modulates face repetition priming: A psychopharmacological fMR1 study显示文摘 | Thiel C M Henson R N A Dolan R J | 2002 | Neuropsychopharmacology2002，27，2： | 1 |
| 10 | Nonlinear State Estimation and Model Predictive Control of Nitrogen Purification Columns 显示文摘 | BIAN S HENSON M A BELANGER P | 2005 | Industrial and Engineering Chemistry Research2005，44，1： | 1 |
| 11 | The effect of soil sample handling between collection and drying on nitrate concentration显示文摘 | Westfall D G Henson M A Evans E P | 1978 | Communications in Soil Science and Plant Analysis1978，9，2： | 1 |
| 12 | Compartmental Modeling of High Purity Air Separation Columns显示文摘 | BIAN S KHOWINIJIA S HENSON M A | 2005 | Computers and Chemical Engineering2005，29，： | 1 |
| 13 | Influence of vitamin C supplementation on cytokine changes following an ultramarathon显示文摘 | NIEMAN D C PETERS E M HENSON D A | 2000 | J Int Cytokine Res2000，20，11： | 1 |
| 14 | Algebraic multigfid based on element interpolation (AMGe)显示文摘 | Brezina M Cleary A J Falgout R D Henson V E Jones J E Manteuffel T A McCormick S F Ruge J W | 2000 | Journal of Scientific Computing2000，22，5： | 1 |
| 15 | Neutrophilendothelial cell interactions显示文摘 | TONNESEN M G SMEDLY L A HENSON P M | 1984 | J Clin Inbest1984，74，6： | 1 |
| 16 | Carbohydrate Ingestion Influences Skeletal Muscle Cytokine mRNA and Plasma Cytokine Levels after a 3-h Run显示文摘 | D C NIEMAN J M DAVIS D A HENSON | 2003 | J Appl Physiol2003，94，5： | 1 |
| 17 | Dynamic modeling and linear model predictive control of gas pipeine networks显示文摘 | ZHU Guangyan HENSON M A MEGAN L | 2001 | Journal of Process Control2001，11，： | 1 |
| 18 | Adaptive Nonlinear Control of a pH Neutralization Process 显示文摘 | M A Henson D E Seborg | 1994 | IEEE Trans on Control Systems Tech1994，2，3： | 1 |
| 19 | Nonlinear model predictive control: current status and future directions 显示文摘 | Henson M A | 1998 | Computers & Chemical Engineering1998，23，2： | 1 |
| 20 | Starchgranule distribution between cell types of alfalfa nodules as affected by symbiotic development 显示文摘 | HOSTAK M S HENSON C A DUCK S H | 1986 | Can J Bot1986，，65： | 1 |
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