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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsiveness显示文摘 | Hens G Raap U Vanoirbeek J | | 0，，04： | 1 |
| 3 | Terahertz radar cross section measurements显示文摘 | Krzysztof I Henning H Peler U J | 2010 | Optics Express2010，18，26： | 1 |
| 4 | Fuel handling system for core elements of a pebble-bed reactor显示文摘 | HENNINGS U | 1969 | Nuclear Applications and Technology1969，7，： | 1 |
| 5 | Human Cord Blood Mononuclear Cells Decrease Cytokines and Inflammatory Cells in Acute Myocardial Infarction显示文摘 | Henning RJ Shariff M Eadula U | 2008 | Stem Cells Dev2008，17，： | 1 |
| 6 | Investigation on the precaecal digestibility of maize, sunflower, cottonseed, linseed and soybean meal in pig with ileorectal anastomosis显示文摘 | Henning U Winsche J Borgmann E | 1992 | Arch Anim Nutr1992，42，： | 1 |
| 7 | The use of mi- croorganisms in L-aseorbic acid production 显示文摘 | Bremus C Hen'mann U Bringer-Meyer S | 2006 | Biotechnology2006，124，1： | 1 |
| 8 | Increased serum S100B in elderly,chronic schizophrenic patients:negative correlation with deficit symptoms显示文摘 | Schmitt A Bertsch T Henning U | | 0，，： | 1 |
| 9 | Microcavity affects in a spin-coated polymer two-layer system显示文摘 | Lemmer U Henning R Guss W | 1995 | Appl Phys Lett1995，66，： | 1 |
| 10 | Thermally activated delayed fluorescence materials towards the breakthrough oforganoelectronics显示文摘 | Tao Y Y u a n K C hen T e t a l | 2014 | Advanced M aterials2014，26，： | 1 |
| 11 | Elongation,Al concentration and hematoxylin staining of aluminum-treated wheat roots 显示文摘 | HENNING S J ANDERSON I C | 1982 | Iowa State J Res1982，57，： | 1 |
| 12 | Increased levels of glueocorticold receptors and enhanced glucocorticoid receptor auto-regulation after hydrocortisone challenge in B-lymphoblastoids from patients with affective disorders 显示文摘 | Henning U Krieger K Loeffler S | 2005 | Psychoneuroendocrinology2005，30，： | 1 |
| 13 | Noble metal catalysts sup- ported on gadolinium doped ceria used for natural gas reforming in fuel cell applications显示文摘 | Hennings U Reimert R | 2007 | Applied Cataly- sis B : Environmental2007，70，： | 1 |
| 14 | Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine显示文摘 | Trossbacha SV Fehselc K Henning U | 2014 | Behav Brain Res2014，275，： | 1 |
| 15 | Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine显示文摘 | von Wilmsdorff M Bouvier M L Henning U | 2014 | Horm Metab Res2014，46，11： | 1 |
| 16 | Increased serum S100B in elderly, chronic schizophrenic patients: negative correlation with deficit symptoms显示文摘 | Schmitt A Bertsch T Henning U | 2005 | Schizophr Res2005，80，23： | 1 |
| 17 | Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease显示文摘 | HENNING J STRAUSS U WREE A | 2008 | Neurosci Res2008，62，4： | 1 |
| 18 | Neuropsyc-hological measurea of attention and memory function in schizophrenia relationships with symptoms dimensions and serum monoamine activify显示文摘 | OADES R D ROPCKE B HENNING U | 2005 | Behav Brain Funt2005，9，1： | 1 |
| 19 | Trace metal impact into the Baltic Sea during the exceptional Oder flood in sum- mer 1997显示文摘 | Pohl C Hennings U Siegel H Bachor A | 2002 | Mar Chem2002，79，34： | 1 |
| 20 | Single-stranded antisense siRNAs guide target RNA cleavage in RNAi显示文摘 | Javier M Agnieszka P Henning U | 2002 | Cell2002，110，5： | 1 |
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