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| 1 | Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F.Muell显示文摘Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic cataract.Methods:Total phenol and flavonoid content of different fractions was determined.ARI activity of different fractions in rat lens was investigated in vitro.Results:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid content.The extract after further evaluation may be used in the treatment of diabetic cataract. | Patel DK Kumar R Kumar M Sairarn K Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 2 | Detection of AmpC beta lactamases production in Escherichia coli & Klebsiella by an inhibitor based method 显示文摘 | Hemalatha V Padma M Sekar U | 2007 | Indian J Med Res2007，126，3： | 1 |
| 3 | A Survey on Software Protection Techniques against Various Attacks显示文摘 | Sasirekha N Hemalatha M | 2012 | Global Journal of Computer Science and Technology2012，12，1： | 1 |
| 4 | Fish protein hydrolysates : Proximate composition, amino acid composition, antioxidant activities and applications : A review 显示文摘 | M Chalamaiah B Dinesh kumar R Hemalatha | 2012 | Food Chemistry2012，135，4： | 1 |
| 5 | Fish protein hydrolysates:Proximate composition, amino acid composition, antioxidant activities and applications:A review显示文摘 | Chalamaiah M Kumar B D Hemalatha R Jyothirmayi T | 2012 | Food Chemistry2012，135，4： | 1 |
| 6 | Protein characteristics and peroxidase activities of different In- dian wheat varieties and their relationship to chapati- making quality显示文摘 | Hemalatha M S Manu B T Bhagwat S G | 2007 | European Food Research and Tech- nolog2007，225，： | 1 |
| 7 | Anti-inflammatory treatmentsfor chronic diseases:a review 显示文摘 | Laveti D Kumar M Hemalatha R | 2013 | Inflammation & Allergy-Drug Targets(Formerly Current Drug Targets-Inflammation & Allergy)2013，12，5： | 1 |
| 8 | Myocardial ischemia and reperfusion injury in rats: lysosomal hydrolases and matrix metalloproteinases mediated cellular damage 显示文摘 | Tiwari M Hemalatha T Ganesan K | 2008 | Mol Cell Biochem2008，312，12： | 1 |
| 9 | Chemotaxonomical studies in some species of Euphorbia显示文摘 | Hemalatha A Radhakrishnaiah M | 2001 | Journal of Economic and Taxonomic Botany2001，1，25： | 1 |
| 10 | Fish protein hydrolysates: proximate composition, amino acid composition, antioxidant activities and applications: a review显示文摘 | CHALAMAIAH M DINESH KUMAR B HEMALATHA R | 2012 | Food Chemistry2012，135，： | 1 |
| 11 | Fish protein hydrolysates: Proximate composition, amino acid composition, antioxidant activities and applications: A review 显示文摘 | CHALAMAIAH M HEMALATHA R JYOTHIEMAYI T | 2012 | Food Chemistry2012，135，4： | 1 |
| 12 | Protein characteristics and peroxidase activities of different Indian wheat varieties and their relationship to chapati- making quality显示文摘 | Hemalatha M S Manu B T | 2007 | European Food Research and Teclmology2007，225，34： | 1 |
| 13 | Associa- tion of T-regulatory cells and CD23/CD21 expression with vitamin D in children with asthma 显示文摘 | CHARY A V HEMALATHA R MURALI M V | 2016 | Ann Allergy Asthma Immuno12016，116，5： | 1 |
| 14 | Synthesis,structure,andelectrochemical properties of the layered sodium insertion cathodematerial;NaNi1/3MnI/3CoI/302 显示文摘 | Sathiya M Hemalatha K Ramesha K | 2012 | Chemistry of Materials2012，24，： | 1 |
| 15 | Control of chapati staling upon treatment of dough with amylases and xylanase显示文摘 | Hemalatha M S Leelavathib K Salimath P V | 2014 | Food Bioscience2014，，5： | 1 |
| 16 | Chemical composition and immunomodulatory effects of enzymatic protein hydrolysates from common carp (Cyprinus carpio) egg (roe)显示文摘 | CHALAMAIAH M HEMALATHA 1K JYOTHIRMAYI T | 2015 | Nutrition2015，31，02： | 1 |
| 17 | Synthesis and character- ization of novel mesoporous CuO and its application to CO2 capture 显示文摘 | Peng M M Hemalatha P Ganesh M | 2013 | Asian J Chem2013，25，17： | 1 |
| 18 | Sesame lignans enhance antioxidant activity of vitamin E in lipid peroxidation systems 显示文摘 | Ghafoorunissa Hemalatha S Rao M V | 2004 | Molecular and Cellular Biochemistry2004，262，： | 1 |
| 19 | hnproved preprocessing techniques for analyzing patterns in Web personalization process显示文摘 | GOBINATH R HEMALATHA M | | 0，，03： | 1 |
| 20 | Detection of AmpC beta lactamases production in Escherichia coli & KlebsieUa by an inhibitor based method 显示文摘 | Hemalatha V Padma M Sekar U | 2007 | Indian J Med Res2007，126，3： | 1 |
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