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| 1 | MicroRNAs in pancreatic ductal adenocarcinoma显示文摘Ductal adenocarcinoma of the pancreas is a lethal cancer for which the only chance of long-term survival belongs to the patient with localized disease in whom a potentially curative resection can be done. Therefore, biomarkers for early detection and new therapeutic strategies are urgently needed. miRNAs are a recently discovered class of small endogenous non-coding RNAs of about 22 nucleotides that have gained attention for their role in downregulation of mRNA expression at the post-transcriptional level. miRNAs regulate proteins involved in critical cellular processes such as differentiation, proliferation, and apoptosis. Evidence suggests that deregulated miRNA expression is involved in carcinogenesis at many sites, including the pancreas. Aberrant expression of miRNAs may upregulate the expression of oncogenes or downregulate the expression of tumor suppressor genes, as well as play a role in other mechanisms of carcinogenesis. The purpose of this review is to summarize our knowledge of deregulated miRNA expression in pancreatic cancer and discuss the implication for potential translation of this knowledge into clinical practice. | Jong Y Park James Helm Domenico Coppola Donghwa Kim Mokenge Malafa Seung Joon Kim | 2011 | World Journal of Gastroenterology2011，17，7： | 7 |
| 2 | Dissecting ramoplanin:mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics显示文摘 | Chen L Yuan Y Helm JS | 2004 | J Am Chem Soc2004，12，： | 1 |
| 3 | A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci显示文摘 | Liu Y Helms C Liao W | 2008 | PLo S Genet2008，4，10： | 1 |
| 4 | Amine-quinone polymers and the protection of iron particles against corrosion 显示文摘 | Han M J Helms A B Hu Y Q | 1999 | IEEE Trans Magn1999，35，5： | 1 |
| 5 | Arterial remodeling after ballon angioplasty or stenting in an atherosclerodc experimental model 显示文摘 | Post MJ Semet BJ Helm Y | 1997 | Circulation1997，96，3： | 1 |
| 6 | Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence res onanee energy transfer显示文摘 | Helm R Tsien R Y | 1996 | Current Biology1996，6，2： | 1 |
| 7 | MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies显示文摘 | Savic I Osterman Y Helms G | 2004 | Neuroimage2004，21，： | 1 |
| 8 | Meniscal tear: pathological correlation with MR imaging显示文摘 | Stoller DW Helms CA Ariari Y | 1987 | Radiology1987，163，： | 1 |
| 9 | Cloning and restriction fragment length polymorphism analysis of a cDNA for swine PIT1, a gene control growth hormone expression显示文摘 | Tuggle C K Yu Y P Helm J | 1993 | Animal Genetics1993，24，： | 1 |
| 10 | Arterial remodeling after balloon angioplasty or stenting in the Yucatan atherosclerotic micropig model:an anngiographic, serial intravascular ultrasound and histology study显示文摘 | Post MJ de Smet BJGL van der Helm Y | | 0，，： | 1 |
| 11 | A new look at dry eye disease and its treatment 显示文摘 | Nelson JD Helms H Fiscella R Southwell Y Hirsch JD | 2000 | Adv Ther2000，17，2： | 1 |
| 12 | Long-term functional and morphological outcome after pyeloplasty for huge renal pelvis显示文摘 | Sarhan O Helm y T Aboul-E1 Ghar M | | 0，，05： | 1 |
| 13 | Regeneration,repair and remembering identity: The three Rs of Hox gene expression显示文摘 | WANG K C HELMS J A CHANG H Y | 2009 | Trends in Cell Biology2009，19，6： | 1 |
| 14 | Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer显示文摘 | Helm R Tsien R Y | 1996 | Curr Biol1996，6，： | 1 |
| 15 | A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci显示文摘 | Liu Y Helms C Liao W | 2008 | PLoS Genet2008，4，10： | 1 |
| 16 | Improved green fluorescence显示文摘 | HElM R CUBITF A B TISEN R Y | 1995 | Nature1995，373，： | 1 |
| 17 | Learning by observation requires an early sleep window 显示文摘 | VAN DER WERF Y D VAN DER HELM E SCHOONHEIM M M | 2009 | Proc Natl Acad Sci U S A2009，106，18： | 1 |
| 18 | A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci 显示文摘 | Liu Y Helms C Liao W | 2008 | PLoS Genet2008，4，3： | 1 |
| 19 | CHD7 cooperates with PBAF to control multipotent neural crest formation显示文摘 | Bajpai R Chen D A Rada-Iglesias A Zhang J Xiong Y Q Helms J Chang C P Zhao Y M Swigu | | 0，，： | 1 |
| 20 | Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model显示文摘 | Post MJ de Smet BJ van der Helm Y | 1997 | Circulation1997，96，3： | 1 |
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