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| 1 | In vitro antibacterial effect of aqueous and ethanolic Moringa leaf extracts显示文摘Objective:To evaluate the antibacterial effect of aqueous and ethanolic moringa leaf extracts (Moringa oleifera) on the growth of gram-positive and negative bacteria.Methods:Paper disks were soaked with 100,200,300 and 400μL of extract at 20 g/180mL and 10 g/190 mL.All extracts were tested against Escherichia coli(ATCC25922),Staphylococcus aureus(ATCC25923),Vibrio parahaemolyticus,Enterococcus faecalis(ATCC29212),Pseudomonas aeruginosa(ATCC27853), Salmonella enteritidis(IH) and Aeromonas caviae.The susceptibility tests were performed using the modified disk diffusion method.Results:The strains E.coli,P.aeruginosa and S.enteritidis (IH) were resistant to all treatments.In general,disks with 400μL extract were the most efficient against S.aureus,V.parahaemolyticus,E.faecalis and A.caviae.Conclusions:The study indicates a promising potential for aqueous and ethanolic Moringa leaf extracts as alternative treatment of infections caused by the tested strains. | Jackson Rafael Oliveira Peixoto Giselle Cristina Silva Renata Albuquerque Costa Joseires Lira de Sousa Fontenelle Gustavo Hitzschky Fernandes Vieira Antonio Adauto Fonteles Filho Regine Helena Silva dos Fernandes Vieira | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，3： | 7 |
| 2 | Siderophore-Producing Rhizobacteria as a Promising Tool for Empowering Plants to Cope with Iron Limitation in Saline Soils:A Review显示文摘Iron(Fe) bioavailability to plants is reduced in saline soils;however, the exact mechanisms underlying this effect are not yet completely understood. Siderophore-expressing rhizobacteria may represent a promising alternative to chemical fertilizers by simultaneously tackling salt-stress effects and Fe limitation in saline soils. In addition to draught, plants growing in arid soils face two other major challenges: high salinity and Fe deficiency. Salinity attenuates growth, affects plant physiology, and causes nutrient imbalance,which is, in fact, one of the major consequences of saline stress. Iron is a micronutrient essential for plant development, and it is required by several metalloenzymes involved in photosynthesis and respiration. Iron deficiency is associated with chlorosis and low crop productivity. The role of microbial siderophores in Fe supply to plants and the effect of plant growth-promoting rhizobacteria(PGPR) on the mitigation of saline stress in crop culture are well documented. However, the dual effect of siderophore-producing PGPR, both on salt stress and Fe limitation, is still poorly explored. This review provides a critical overview of the combined effects of Fe limitation and soil salinization as challenges to modern agriculture and intends to summarize some indirect evidence that argues in favour of siderophore-producing PGPR as biofertilization agents in salinized soils. Recent developments and future perspectives on the use of PGPR are discussed as clues to sustainable agricultural practices in the context of present and future climate change scenarios. | Maria J.FERREIRA Helena SILVA Angela CUNHA | 2019 | Pedosphere2019，29，4： | 3 |
| 3 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
| 4 | From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?显示文摘Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease. | Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira | 2022 | Neural Regeneration Research2022，17，5： | 2 |
| 5 | Comparative Life Cycle Analysis of Steel-concrete Composite Bridges显示文摘 | Helena Gervadsio Luis Sire o ES DA Silva | 2008 | Structure and Infrastructure Engineering2008，4，4： | 1 |
| 6 | Modulation of P-glycoprotein efflux pump: Induction and activation as a therapeutic strategy 显示文摘 | SILVA R VILAS-BOAS V HELENA C | 2015 | Pharmacol Ther2015，149，： | 1 |
| 7 | Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome显示文摘 | Tathiana Name Colado Sim?o Marcell Alysson Batisti Lozovoy Andréa Name Colado Sim?o Sayonara Rangel Oliveira Danielle Venturini Helena Kaminami Morimoto Lúcia Helena Silva Miglioranza Isaias Dichi | 2013 | British Journal of Nutrition2013，，10： | 1 |
| 8 | Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis显示文摘在对老旧的螺栓和铆接金属桥进行修补和加固时可以使用不同的方案。由于铆接链接技术目前并不常用,连接它需要特定的设备和熟练的工人。另一种解决方案是使用焊接。但是,老旧钢材的可焊性较差。螺栓是一种非常可行的替代解决方案,并且常用于修复旧金属桥。装配螺栓的解决方案成本高昂,另一种方法是使用树脂灌注式螺栓。带有预紧力的树脂灌注式老旧螺栓连接的受力性能已经用准静态和蠕变试验进行了研究,然而,关于这些连接节点的滑移和疲劳行为的文献很少。本文概述了几位研究者的实验项目,旨在评估单侧受剪和双侧受剪的树脂灌注式螺栓连接的疲劳行为。对有预紧力的标准螺栓和有预紧力的树脂灌注式螺栓的连接节点的实验数据进行比较分析,显示后者的疲劳强度较低。但欧洲规范3(EC3)对树脂灌注式螺栓和标准螺栓的连接节点提出的疲劳强度曲线大致相同,这应得到足够的重视。此外,本研究还展示了使用黏结螺栓连接的可行性研究。最后的研究是用高强度低合金结构钢板和用于金属黏结的丙烯酸结构黏结剂进行的。针对两个实际工程案例,使用线性化边界及Castillo和Fernández-Canteli模型对疲劳实验数据进行统计分析。最终提出疲劳设计曲线,并与欧洲和北美规范中的几个设计建议进行比较。 | Jose Antonio Fonseca de Oliveira Correia Bruno Alexandre Silva Pedrosa Patricia Cordeiro Raposo Abilio Manuel Pinho De Jesus Helena Maria dos Santos Gervisio Grzegorz Stanislaw Lesiukc Carlos Alberto da Silva Rebelo Rui Artur Bartolo Calcada Luis Alberto Proenca Simoes da Silva | 2017 | Engineering2017，3，6： | 1 |
| 9 | Serum pepsinogen test for early detection of gastric cancer in a European Country显示文摘 | Rafael Lomba-Viana Mário Dinis-Ribeiro Fernando Fonseca Anabela Silva Vieira Maria José Bento Bento Helena Lomba-Viana | 2012 | European Journal of Gastroenterology & Hepatology2012，，1： | 1 |
| 10 | ANTIBACTERIAL EFFECT (in vitro) OF Moringa oleifera AND Annona muricata AGAINST GRAM POSITIVE AND GRAM NEGATIVE BACTERIA显示文摘 | Vieira Gustavo Hitzschky Fernandes Mour?o Jozeanne Alves ?ngelo ?ngela Maria Costa Renata Albuquerque Vieira Regine Helena Silva dos Fernandes | 2010 | Revista do Instituto de Medicina Tropical de S茫o Paulo2010，，3： | 1 |
| 11 | Primary biliary cirrhosis in a rheumatoid arthritis patient treated with rituximab, a case-based review显示文摘 | Joaquim Polido-Pereira Ana Maria Rodrigues Helena Canh?o Fernando Saraiva José Alberto Pereira Silva Jo?o Eurico Fonseca | 2012 | Clinical Rheumatology2012，，2： | 1 |
| 12 | Second order effects in slender concrete columns-reformulation of the Eurocode 2 method based on nominal curvature显示文摘 | Helena Barros Vitor D. Silva Carla Ferreira | 2010 | Engineering Structures2010，，12： | 1 |
| 13 | The absolute configuration of 1- (3', 4'-dihydroxyeinnamoyl) eyelopentane-2,3-diol from the amazonian tree Chimarrhis turbinate 显示文摘 | Carmen Lucia Cardoso Vanderlan da Silva Bolzani Dulce Helena Siqueira Silva | 2006 | Journal of Nature Product2006，69，： | 1 |
| 14 | Argon plasma coagulation therapy for hemorrhagic radiation proctosigmoiditis显示文摘 | Rui A. Silva António J. Correia Luís Moreira Dias Helena Lomba Viana Rafael Lomba Viana | 1999 | Gastrointestinal Endoscopy1999，，： | 1 |
| 15 | Islet Neogenesis Associated Protein (INGAP) modulates gene expression in cultured neonatal rat islets显示文摘 | Helena Barbosa Silvana Bordin Luiz Stoppiglia Kelly Silva Maria Borelli Héctor Del Zotto Juan Gagliardino Antonio Boschero | 2006 | ScienceDirect2006，136，： | 1 |
| 16 | Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential显示文摘Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(P.capillacea) and Osmundaria obtusiloba.Methods:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content quantification.Antimicrobial activity was tested using the method of disc diffusion on Mueller-Hinton medium.The ability of algal extracts to agglutinate bacterial cells was also tested.Results:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex extract.The results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of P.capillacea(33.04%and 40.81%) at a concentration of 1 000 μg/mL.As for the ferrous ion chelating,there was an opposite behavior,extracts of P.capillacea had a higher activity.The extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to 0.180.Antioxidant activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains tested.However,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio harveyi.Conclusions This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells. | Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos Santos Kelma Maria dos Santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos Fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，4： | 1 |
| 17 | PCR multiplex for detection of Salmonella Enteritidis, Typhi and Typhimurium and occurrence in poultry meat显示文摘 | Camila Guimar?es de Freitas ?ngela Patrícia Santana Patrícia Helena Caldeira da Silva Vítor Salvador Pic?o Gon?alves Márcia de Aguiar Ferreira Barros Fernando Araripe Gon?alves Torres Luci Sayori Murata Simone Perecmanis | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 18 | Social Network Marketing Strategy and SME Strategy Benefits显示文摘 | Helena Nobre Daniela Silva | 2014 | Journal of Transnational Management2014，19，2： | 1 |
| 19 | Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifoliurn显示文摘 | Joaquim Corsino Dulce Helena Siqueira Silva Maria Valnice Boldrin Zanoni | 2003 | Phytotherapy Research2003，17，8： | 1 |
| 20 | Development of new methods for determining the heparanase enzymatic activity显示文摘 | Carina Mucciolo Melo Ivarne Luis Santos Tersariol Helena Bonciani Nader Maria Aparecida Silva Pinhal Marcelo Andrade Lima | 2015 | Carbohydrate Research2015，，： | 1 |
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