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| 1 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 7 |
| 2 | Identifying microRNA panels specifically associated with hepatocellular carcinoma and its different etiologies显示文摘Aim:Deregulation of microRNAs(miRNAs)expression has been identified in hepatocellular carcinoma(HCC),but few results are consistent.The objective of this study is to investigate“HCC tumor type specific”and“tumor common”miRNA panels.Methods:The authors integrate and analyze clinical,etiologic and miRNA profiles data from 9 types of solid tumors in The Cancer Genome Atlas(TCGA)and HCC data from Columbia University Medical Center(CUMC).Results:Levels of 33 miRNAs were significant different between HCC tumor and paired non-tumor tissues(over 2-fold changes)after Bonferroni correction for multiple comparisons,and most(28 miRNAs)were down-regulated in HCC tumors.Using this panel,the authors well classified HCC tumor tissues with 4 misclassifications among 48 paired tissues.Validating this panel in an additional 302 HCC tumor tissues,the authors almost perfectly distinguished tumor from non-tumor tissues with only two misclassifications(99%of HCC tissues correctly classified).Evaluating miRNA profiles in 32 independent HCC paired tissues from CUMC,the authors observed 40 miRNAs significantly deregulated in HCC with over 2-fold changes;14 overlapped with those identified in TCGA.Subgroup analyses by HCC etiology found that 4 upregulated and 8 downregulated miRNAs were significantly associated with alcohol-related HCC.There were 7 and 4 miRNAs significantly associated with hepatitis B virus-and hepatitis C virus-related HCC,respectively.Data for the first time revealed that miR-24-1,miR-130a and miR-505 were significantly down-regulated only in HCC tumors;miR-142 and miR-455 were significantly down-regulated in HCC,but up-regulated in 5 other solid tumors;suggesting their HCC“tumor type specific”characteristics.A panel of 8 miRNAs was significant in at least 5 tumor types,including HCC,and was identified as“tumor common”marker.Conclusion:The authors concluded that aberrant miRNA panels have HCC“tumor type specificity”and may be affected by etiologic factors. | Jing Shen Abby B.Siegel Helen Remotti Qiao Wang Regina M.Santella | 2016 | Hepatoma Research2016，2，1： | 4 |
| 3 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O'Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 1 |
| 4 | Long-lived intestinal tuft cells serve as colon cancer-initiating cells显示文摘 | Westphalen C Benedikt Asfaha Samuel Hayakawa Yoku Takemoto Yoshihiro Lukin Dana J Nuber Andreas H Brandtner Anna Setlik Wanda Remotti Helen Muley Ashlesha Chen Xiaowei May Randal Houchen Courtney W Fox James G Gershon Michael D Quante Mich | 2014 | Journal of Clinical Investigation2014，，3： | 1 |
| 5 | The steatohepatitic variant of hepatocellular carcinoma and its association with underlying steatohepatitis显示文摘 | Marcela Salomao Helen Remotti Roger Vaughan Abby B. Siegel Jay H. Lefkowitch Roger Klein Moreira | 2012 | Human Pathology2012，，5： | 1 |
| 6 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 1 |
| 7 | Diabetes, Body Mass Index, and Outcomes in Hepatocellular Carcinoma Patients Undergoing Liver Transplantation显示文摘 | Abby B. Siegel Emerson A. Lim Shuang Wang William Brubaker Rosa D. Rodriguez Abhishek Goyal Judith S. Jacobson Dawn L. Hershman Elizabeth C. Verna Jonah Zaretsky Karim Halazun Lorna Dove Robert S. Brown Alfred I. Neugut Tomoaki Kato Helen Remotti Yael J. | 2012 | Transplantation Journal2012，，5： | 1 |
| 8 | Neoadjuvant Chemotherapy and Radiation for Patients with Locally Unresectable Pancreatic Adenocarcinoma: Feasibility, Efficacy, and Survival显示文摘 | John D. Allendorf Margaret Lauerman Aliye Bill Mary DiGiorgi Nicole Goetz Efsevia Vakiani Helen Remotti Beth Schrope William Sherman Michael Hall Robert L. Fine John A. Chabot | 2008 | Journal of Gastrointestinal Surgery2008，，1： | 1 |
| 9 | Diagnosis of gastrointestinal stromal tumors: A consensus approach显示文摘 | Christopher D.M. Fletcher Jules J. Berman Christopher Corless Fred Gorstein Jerzy Lasota B.Jack Longley Markku Miettinen Timothy J. O’Leary Helen Remotti Brian P. Rubin Barry Shmookler Leslie H. Sobin Sharon W. Weiss | 2002 | Human Pathology2002，，5： | 1 |
| 10 | Evaluating normalization approaches for the better identification of aberrant microRNAs associated with hepatocellular carcinoma显示文摘Aim:Dysregulated microRNAs(miRNAs)have been identified in hepatocellular carcinoma(HCC),but only a small proportion have been confirmed.An appropriate normalizer is crucial to determining the accuracy and reliability of data from miRNA studies.Methods:Different normalization strategies were used to validate genome-wide miRNA profiles in HCC tumor and non-tumor tissues,and to determine the consistency and discrepancy of data on dysregulated miRNAs.Results:Two sets of stable miRNAs(miR-30c/miR-30b and miR-30c/miR-126)were identified in HCC tissues by geNorm and NormFinder tools,respectively.The mean of global miRNAs also showed good stability for ranking the top 1-2 miRNAs,but the stabilities of the manufacturer-recommended ncRNAs controls were poor.Four panels of miRNAs were significantly associated with HCC by separately using various normalizers,and 14 miRNAs were consistently identified by three normalization strategies.Although fewer miRNAs(17-26)were dysregulated in HCC using the global mean or the 2 stable miRNAs as normalizers,perfect clustering of tissues was also obtained with only 1 to 2 misclassifications,suggesting the efficiency of the miRNA panels.Using global mean as the normalizer,the authors identified 7 miRNAs,including 2 novel(miR-324-5p and miR-550)significantly upregulated in HCC that were omitted when using 3 endogenous controls as the normalizer.Conclusion:An optimal normalization strategy to identify biologically important miRNAs in HCC tissue studies of miRNA may be the combination of global mean and 2 stable miRNAs.Selection of appropriate normalization strategies to adjust miRNAs levels is particularly important for epidemiological studies dealing with large data sets and covering multiple experimental batches. | Jing Shen Qiao Wang Irina Gurvich Helen Remotti Regina MSantella | 2016 | Hepatoma Research2016，2，1： | 0 |
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