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835篇 您的检索式：作者名="Heinrich J"

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	题名	作者	年代	出处	被引量
1	Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors.	Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler	2008	World Journal of Gastroenterology2008，14，24：	2
2	Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product显示文摘	NAKAGAMA H HEINRICH G PELLETIER J	1995	Mol Cell Biol1995，15，3：	1
3	Regeneration of the sciatic nerve in the rat modified by neurotrophic factors显示文摘	Kunnemann J Dietzmann K Heinrich P	1991	Zentraible Neurochir1991，52，3：	1
4	Ex-situ process for treating PAH-contaminated soil with Phanerochaete Chrysosporium显示文摘	ROBERT M PETER S HEINRICH S J	1997	Environmental Science and Technology1997，，31：	1
5	Association of hypertensive status and its drug treatment with lipid and haemostatic factors in middle-aged men: the PRIME study显示文摘	Junker R Heinrich J Schulte H	2000	J Hum Hypert2000，14，：	1
6	Evaluating forages and TMRs using the penn state particle size separator显示文摘	Heinrichs J	1996	Penn State Cooperative Extension Service1996，，：	1
7	Aqueous tape casting of silicon nitrid-e显示文摘	Bitterlich B Heinrich J G	2002	Journal of the European Ceramic Society2002，22，：	1
8	A study of the use of milk replacers for dairy calves in the United States显示文摘	Heinrichs A J Wells S J Losinger W C	1995	J Dairy Sci1995，，78：	1
9	Use of a whole genome approach to identify vaccine molecules affording protection against topneumococcal bacteremia infection显示文摘	Wizemann T M Heinrichs J H Adamou J E		0，，03：	1
10	Arthroscopic-assisted hook plate fixation for acremioclavicular joint dislocation 显示文摘	Gille J Heinrichs G Unger A	2013	Int Or- thop2013，37，1：	1
11	Recombinant human interleukin-6 (IL-6/ BSF-2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes 显示文摘	Casted JV Gomez-Lechon M J David M Hirano T Kishimoto T Heinrich PC	1988	FEBS Lett1988，232，2：	1
12	Calibration for interelement effects in X-ray fluorescence analysis显示文摘	RASBERRY S D HEINRICH K F J	1974	Analytical Chemistry1974，46，1：	1
13	Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig显示文摘	Heinrich UR Fischer I Brieger J	2008	Laryngoscope2008，118，5：	1
14	Angiotensin Ⅱ ahterogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis 显示文摘	Keidar S Attias J Heinrich R	1999	Atherosclerosis1999，146，2：	1
15	Plasma fibrinogen in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction显示文摘	Tataru MC Schulte H von Eckardstein A Heinrich J Assmann G Koehler E	2001	Coron Artery Dis 2001 May2001，12，3：	1
16	C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris显示文摘	Tataru MC Heinrich J Junker R	2000	Eur Heart J2000，21，12：	1
17	CSF-1, RANKL and OPG regulate osteoclastogenesis during murine tooth eruption 显示文摘	HEINRICH J BSOUL S BARNES J	2005	Arch Oral Biol2005，50，10：	1
18	Front - Tracking Finite Element Method for Dendritic Solidification 显示文摘	ZHAO P HEINRICH J C	2001	Journal of Computational Physics2001，175，：	1
19	Effects of mannan oligosaccharide or antibiotics in neonatal diets on health and growth of dairy calves显示文摘	Heinrichs A J Jones C M Heinrichs B S	2003	J Dairy Sci2003，86，：	1
20	Pharmacologic inhibition of PKCct and PKC0 prevents GVHD while preserving GVL activity in mice显示文摘	Haarberg KM Li J Heinrichs J	2013	Blood2013，122，14：	1

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