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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women显示文摘 | Fowke J H Longcope C Hebert J R | 2000 | Cancer Epidemiol Biomarkers Prev2000，9，8： | 1 |
| 3 | Barcoding animal life : cytechmme c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceedings of the Royal Society of London B : Biolocal Sciences2003，270，1： | 1 |
| 4 | Scanning mutagenesis of interleukin - 8 identifies a cluster of residues required for receptor binding显示文摘 | Hebert C A Vitangcol R V Baker J B | 1991 | J Biol Chem1991，266，18： | 1 |
| 5 | Bar coding animal life:Cytoehrome c oxidase subunit 1 di vergences among closely related species显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceed ings of the Royal Society of London Series B:Biologi cal Sciences2003，270，： | 1 |
| 6 | Brassica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women显示文摘 | Fowke J H Longcope C Hebert J R | 2000 | Cancer Epidemiol Biomarkers Prev2000，9，： | 1 |
| 7 | Vascular dementia:incidence and risk factors in the Canadian study of health and aging显示文摘 | Lindsay J Verreault R | 2000 | Stroke2000，31，： | 1 |
| 8 | Implementation of functional autonomy measurement system: barriers and facilitators in PISE-Dordogne project显示文摘 | Gervais P Hebert R Lamontagne J | 2011 | Geriatric et psychol- ogic neuropsychiatrie du vieillissement2011，9，： | 1 |
| 9 | Observations of the early stages of the pitting corrosion of aluminum显示文摘 | Wiersma B J Hebert K R | 1991 | J Electrochem Soc1991，138，1： | 1 |
| 10 | Reliability of the re- vised functional autonomy measurement system (SMAF) for epidemiological research显示文摘 | Desrosiers J Bravo G Hebert R | 1995 | Age and ageing1995，24，： | 1 |
| 11 | GST polymorphism and excretion of heterocyclic aromatic amine and isothiocyanate metabolites after Brassica consumption显示文摘 | Steck S E Hebert J R | 2009 | Environ Molecul Mutagen2009，50，3： | 1 |
| 12 | Synthesis of nanostructures from amorphous and crystalline phases显示文摘 | Perepezko J H Hebert R J | 2004 | Mater Sci Eng: B2004，375，： | 1 |
| 13 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Dewaard J R | 2003 | Proc R Soc Lond B ( Suppl )2003，270，： | 1 |
| 14 | Barcoding animal life:cytochrome coxidase subunit 1 divergences among closely related species显示文摘 | Hebert P D Ratnasingham S Waard J R | 2003 | Proc Biol Sci2003，270，1： | 1 |
| 15 | Modulation of lens epithelial cell proliferation by enhanced pros- taglandin synthesis after UVB exposure 显示文摘 | Andley U P Hebert J S Morrison A R | 1994 | Invest Ophthalmol Vis Sci1994，35，2： | 1 |
| 16 | Barcoding animal life: cytochrome coxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Ward J R | 2003 | Proc R Soc B Biol Sci2003，270，1： | 1 |
| 17 | Barcoding animal life: cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S Waard J R | 2003 | Proc R Soc Eond Ser B2003，270，1： | 1 |
| 18 | Combining contemporary and traditional project management tools to resolve a project scheduling problem 显示文摘 | HEBERT J E DECKRO R F | 2011 | Computers & Operations Research2011，，38： | 1 |
| 19 | Barcoding animal life:cytochrome c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S deWaard J R | 2003 | Proc Biol Sci2003，270，1： | 1 |
| 20 | Experimental study on the response of graded corrugated steel armor to shock loading 显示文摘 | Wright J Hebert R Maddala D | 2015 | Meccanica2015，50，2： | 1 |
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