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| 1 | 促生长激素分泌素受体基因多态性与肥胖关系显示文摘目的 了解促生长激素分泌素受体 (GHSR)基因多态性与青少年肥胖的关系。方法 选择 184名重度肥胖和 184名低体重青少年 ,对GHSR基因两个单核苷酸多态性 (SNP)进行快速高通量基因型分析。另对 2 70例肥胖、4 9例低体重和 96例体重正常者 ,进行其中 1个单核苷酸的基因多态性 (编号rs4 95 2 2 5 )检测 ,并对 387个肥胖核心家系进行传递 /不平衡检验 (TDT)。结果 在rs4 95 2 2 5多态性位点上 ,肥胖组的 171T等位基因频率 ( 75 0 % )明显高于低体重组 ( 70 2 % ) ,进一步扩大样本的关联分析显示相似趋势 ,但组间均无显著性差异。 387个核心家系中 171等位基因传递率为 5 1 8% ,略高于 171C等位基因 ( 4 8 2 % ) ,亦无显著性差异 (P =0 5 3)。结论 该人群中未发现促生长激素分泌素受体基因 | 王海俊 季成叶 Johannes Hebebrand Anke Hinney | 2004 | 中国公共卫生2004，20，9： | 2 |
| 2 | The role of leptin in anorexia nervosa:clinical implications显示文摘 | Hebebrand J Muller TD Holtkamp K | 2007 | Mol Psychiatry2007，12，： | 1 |
| 3 | Reduced body fat in longterm followed-up female patients with anorexia nervosa显示文摘 | Frey J Hebebrand J Muller B | 2000 | J Psychiatr Res2000，34，： | 1 |
| 4 | Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants显示文摘 | Hinney A Nguyen T T Scherag A Friedel S Bronner G Muller T D Grallert H Illig T Wichmann H E Rief W Schafer H and Hebebrand J | | 0，，12： | 1 |
| 5 | Association analysis of the dopamine D2 receptor gene in Tourette's syndrome using the haplotype relative risk method显示文摘 | Nthen MM Hebebrand J Knapp M | 1994 | Am J Med Genet1994，54，： | 1 |
| 6 | Genes and lifestyle factors in obesity:Results from 12462 subjects from MONICA/KORA显示文摘 | Holzapfel C Grallert H Huth C Wahl S Fischer B Doring A Ruckert I M Hinney A Hebebrand J Wichmann H E Hauner H Illig T and Heid I M | | 0，，10： | 1 |
| 7 | The role of leptin and cortisol in hyperactivity in patients with acute and weight-recovered anorexia nervosa显示文摘 | Stefan Ehrlich Roland Burghardt Nora Schneider Martina Broecker-Preuss Deike Weiss Julia V. Merle Eugenia Maria Craciun Ernst Pfeiffer Klaus Mann Ulrike Lehmkuhl Johannes Hebebrand | 2009 | Progress in Neuropsychopharmacology & Biological Psychiatry2009，，4： | 1 |
| 8 | Genes, lifestyles and obesity显示文摘 | Marti A Moreno-Aliaga MJ Hebebrand J | 2004 | Int J Obes Relat Metab Disord2004，28，3： | 1 |
| 9 | Eating disorders:the current status of molecular genetic research 显示文摘 | Scherags S Hebebrand J Hinney A | 2010 | Eur Child Adolesc Psychiatry2010，19，3： | 1 |
| 10 | A genome - wide scan for atten- tion - deficit/hyperactivity disorder in 155 German sib - pairs显示文摘 | Hebebrand J Dempfle A Saar K | 2006 | Mol Psychiatry2006，11，2： | 1 |
| 11 | Polygenic obesity in humans显示文摘 | Hinney A Hebebrand J | 2008 | Obesity Facts2008，1，1： | 1 |
| 12 | Genetic epidemiology,endophenotypes,and eating disorder classification显示文摘 | Bulik CM Hebebrand J Rahkonen AK | 2007 | Int J Eat Disord2007，40，： | 1 |
| 13 | Genetic predisposition to obesity in bulimia nervosa: a mutation screen of the melanocortin-4 receptor gene显示文摘 | Fichter M Gerbe G | 2002 | Molecular Psychiatry2002，7，6： | 1 |
| 14 | Eating disorders: the cur- rent status of molecular genetic research 显示文摘 | Scherag S Hebebrand J Hinney A | 2010 | Eur Child Adolese Psychiatry2010，19，3： | 1 |
| 15 | Increased body-mass index in patients with narcolepsy显示文摘 | SCHULD A HEBEBRAND J GELLER F | 2000 | Lancet2000，355，9211： | 1 |
| 16 | Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia显示文摘 | J. Hebebrand C. Exner K. Hebebrand C. Holtkamp R.C. Casper H. Remschmidt B. Herpertz-Dahlmann M. Klingenspor | 2003 | Physiology & Behavior2003，，1： | 1 |
| 17 | Genetic aspects in attention-deficit/hyperactivity disorder 显示文摘 | Albayrak O Friedel S Schimmelmann BG Hinney A Hebebrand J | 2008 | J Neural Transm2008，115，2： | 1 |
| 18 | Weight-Reducing Side Effects of the Antiepileptic Agents Topiramate and Zonisamide 显示文摘 | Antel J Hebebrand J | 2012 | Handb EXP pharmcol2012，，209： | 1 |
| 19 | Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans显示文摘 | Schmidt A Nottebom K Heibult O Becker I Ziegler A Gerber G Sina M Gorg T Mayer H Siegfried W Fichter M Remschmidt H Hebebrand J | 1999 | J Clin Endocrinol Metab1999，84，4： | 1 |
| 20 | Candidategene polymorphisms in eating disorders 显示文摘 | HINNEY A REMSCHMIDT H HEBEBRAND J | 2000 | Eur JPharmacol2000，410，11： | 1 |
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