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| 1 | Role of RANKL/RANK in primary and secondary breast cancer显示文摘Bone is one of the most preferential metastatic target sites of breast cancer. Bone possesses unique biological microenvironments in which various growth factors are stored and continuously released through osteoclastic bone resorption, providing fertile soil for circulating breast cancer cells. Bone-disseminated breast cancer cells in turn produce osteotropic cytokines which modulate bone environments. Under the influences of breast cancer-produced cytokines, osteoblasts express elevated levels of Ligand for receptor activator of nuclear factor-κB(RANKL) and stimulate osteoclastogenesis via binding to the receptor receptor activator of nuclear factor-κB(RANK) and activating its downstream signaling pathways in hematopoietic osteoclast precursors, which causes further osteoclastic bone destruction. Establishment of crosstalk with bone microenvironments(so called vicious cycle) is an essential event for metastatic breast cancer cells to develop bone metastasis. RANKL and RANK play a central role in this crosstalk. Moreover, recent studies have demonstrated that RANKL and RANK are involved in tumorigenesis and distant metastasis independent of bone microenvironments. Pharmacological disruption of the RANKL/RANK interplay should be an effective therapeutic intervention for primary breast tumors and bone and non-bone metastasis. In this context, denosumab, which is neutralizing monoclonal antibody against RANKL, is a mechanismbased drug for the treatment of bone metastases and would be beneficial for breast cancer patients with bone metastases and potentially visceral organ metastases. | Toshiyuki Yoneda Soichi Tanaka Kenji Hata | 2013 | World Journal of Orthopedics2013，4，4： | 5 |
| 2 | Clinical and computed tomography findings of appendiceal diverticulitis vs acute appendicitis显示文摘AIM: To study the clinical features and computed tomography(CT) findings of appendiceal diverticulitis vs acute appendicitis.METHODS: We retrospectively reviewed the records of 451 patients who had undergone appendectomy inour in stitution from January 2007 to September 2012. Patient demographics, clinical features, pathological findings, and surgical outcomes were analyzed. We also compared preoperative CT images of 25 patients with appendiceal diverticulitis with those of 25 patients with acute appendicitis.RESULTS: Among 451 patients, 44(9.7%) were diagnosed to have appendiceal diverticulitis and 398(86.9%) to have acute appendicitis. Patients with appendiceal diverticulitis were older(59 vs 37 years, P < 0.001) and had a longer duration of the illness(4.0 d vs 1.0 d, P < 0.001). Perforation rates in patients with appendiceal diverticulitis were higher(68% vs 27%, P < 0.001). The appendix could be visualized in only 13 patients(52%) among the appendiceal diverticulitis cases, but in all acute appendicitis cases. CT findings suggestive of appendiceal diverticulitis included the absence of fluid collection in the appendix(84% vs 12%, P < 0.001), absence of appendicolith(92% vs 52%, P = 0.005), and formation of abscess(68% vs 16%, P < 0.001). Appendiceal diverticula were identified in 6 patients(24%).CONCLUSION: Among patients who had undergone appendectomy, 9.7% had appendiceal diverticulitis. Patients with appendiceal diverticulitis had different clinical features and CT findings from patients with acute appendicitis. | Daisuke Ito Kenji Miki Shimizu Seiichiro Shojiro Hata Kaoru Kobayashi Masanori Teruya Michio Kaminishi | 2015 | World Journal of Gastroenterology2015，21，13： | 3 |
| 3 | Domestic wastewater treatment by a submerged membrane bioreactor with gravitational filtration显示文摘 | Tatsuki Ueda Kenji Hata | 1999 | Water Research1999，，12： | 2 |
| 4 | Up-Regulation of Calcineurin Aβ mRNA in the Alzheimer’s Disease Brain: Assessment by cDNA Microarray显示文摘 | Ryuji Hata Makoto Masumura Hiroyasu Akatsu Feng Li Hiroko Fujita Yasuo Nagai Takayuki Yamamoto Hidechika Okada Kenji Kosaka Masahiro Sakanaka Tohru Sawada | 2001 | Biochemical and Biophysical Research Communications2001，，2： | 1 |
| 5 | New technology for manufacturing high-strength cement-bonded particleboard using supercritical carbon dioxide显示文摘 | Dede Hermawan Toshimitsu Hata Kenji Umemura Shuichi Kawai Shin-ichi Kaneko Yasuo Kuroki | 2000 | Journal of Wood Science2000，，1： | 1 |
| 6 | Domestic wastewater treatment by a submerged membrane bioreactor with gravitational filtration 显示文摘 | Tatsuki Ueda Kenji Hata | 1999 | Water Res1999，33，12： | 1 |
| 7 | Improvements in drying beds for non-concentrated sludge显示文摘 | Masaru Yamaoka Kenji Hata | 2003 | Adv Environ Res2003，7，3： | 1 |
| 8 | Domestic wastewater treatment by a submerged membrane bioreactor with gravitational filtration显示文摘 | Tatsuki Ueda Kenji Hata | 1999 | Water Res1999，33，12： | 1 |
| 9 | Influence of lengths of millimeter-scale single-walled carbon nanotube on electrical and mechanical properties of buckypaper显示文摘 | Shunsuke Sakurai Fuminori Kamada Don N Futaba Motoo Yumura Kenji Hata | 2013 | Nanoscale Research Letters2013，，： | 1 |
| 10 | Effects of aeration on suction pressure in a submerged membrane bioreactor显示文摘 | Ueda Tatsuki Hata Kenji Kikuoka Yasuto | 1997 | Wat Res1997，31，3： | 1 |
| 11 | A rubberlike stretchable active matrix using elastic conductors 显示文摘 | Tsuyoshi Sekitani Yoshiaki Noguchi Kenji Hata | 2008 | Science2008，321，5895： | 1 |
| 12 | Water-assisted highly efficient synthesis of impurity-free single-walled carbon nanotubes显示文摘 | Kenji Hata Sumio lijima | 2004 | Science2004，306，： | 1 |
| 13 | Rapid production of high-strength cement-bonded particleboard using gaseous or supercritical carbon dioxide 显示文摘 | Dede Hermawan Toshimitsu Hata Kenji Vmemura | 2001 | Janpan wood sci2001，47，： | 1 |
| 14 | Production Of cement Particleboard With Steam-injection Pressing 显示文摘 | Dede Hermawan Toshimitsu Hata Kenji Umemura | 2001 | J Wood Sci2001，，47： | 1 |
| 15 | Domestic wastewater treatment by a submerged membrane bioreactor with gravitational filtration 显示文摘 | Tatsuki Ueda Kenji Hata | 1999 | Water Research1999，33，12： | 1 |
| 16 | Domestic wastewater treatment by a submerged membrane bioreactor with gravitational filtration 显示文摘 | Tatsuki Ueda Kenji Hata | 1999 | Water Research1999，33，12： | 1 |
| 17 | Thermal diffusivity of single-walled carbon nanotube forest measured by laser flash method显示文摘 | Megumi Akoshima Kenji Hata Don N Futaba | 2009 | Jpn J Appl Phys2009，48，： | 1 |
| 18 | Arid5a cooperates with Sox9 to stimulate chondrocyte-specific transcription显示文摘 | Katsuhiko Amano Kenji Hata Shuji Muramatsu | 2011 | Molecular Biol Cell2011，22，12： | 1 |
| 19 | 显示文摘 | Kenji Hata Don N Futaba Sumio Iijima | 2004 | Science2004，306，19： | 1 |
| 20 | Effect of aeration on suction pressure in a submerged membrane bioreactor 显示文摘 | Kenji Hata Yasuto Kikaoka | 1997 | Water Research1997，31，3： | 1 |
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