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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | The naturalhistory of primary dysmen orrhea:a longitudinal study显示文摘 | Weismann A M Hartz A J Hansen M D | 2004 | Br J Obstet Gynaecol2004，111，4： | 1 |
| 3 | Coordinated nuclear receptor regulation of the efflux transporter,Mrp2,and the phaseII metabolizing enzyme,GSTpi,at the blood-brain barrier显示文摘 | Bauer B Hartz A M Lucking J R | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 4 | 显示文摘 | Hartz A J Noyes R Bentler SE | 2000 | Gen Hosp Psycheatry2000，22，3： | 1 |
| 5 | Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants 显示文摘 | Weissman A M Levy B T Hartz A J | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 6 | Mechanisms of unexplained anemia in the nursing home 显示文摘 | HARTZ A S H HFERGUSSON D H HDRINKA P J H | 2004 | HJ Am Geriatr Soe2004，52，3： | 1 |
| 7 | Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants显示文摘 | WEISSMAN A M LEVY B T HARTZ A J | 2004 | The American Journal of Psychiatry2004，161，6： | 1 |
| 8 | Microzooplankton grazing impact in the western Arctic Ocean显示文摘 | Sherr E B Sherr B F Hartz A J | 2009 | Deep-Sea Research Part Ⅱ:Topical Studies in Oceanography2009，，17： | 1 |
| 9 | DCPTA ineffective as a production acid on fieldgrown tomato and pepper显示文摘 | HARTZ T K KIES L J BAOMEUR A | 1995 | Horticultural Science1995，30，1： | 1 |
| 10 | A comparison of observational studies andrandomized,controlled trlals显示文摘 | BENSON K HARTZ A J | 2001 | Am J Ophthalmo12001，130，： | 1 |
| 11 | DCPTA ineffective as a production acid on fieldgrown tomato and pepper显示文摘 | HARTZ T K KIES I J BAOMEUR A | 1995 | Hortscience1995，30，1： | 1 |
| 12 | Pooled analysis of antidepressant levels in lactating mothers,breast milk,and nursing infants显示文摘 | Weissman A M Levy B T Hartz A J | 2004 | Am J Psychiatry2004，161，6： | 1 |
| 13 | A comparison of observational studies and randomized, controlled trials显示文摘 | Benson K Hartz A J | 2000 | Am J Ophthalmol2000，130，5： | 1 |
| 14 | The association of obesity with infertility and related menstural abnormalities in women显示文摘 | Hartz A J Barboriak P N Wong A | | 0，，1： | 1 |
| 15 | Risk factors for insomnia in a Rural population显示文摘 | Hartz A J Daly JM Kohatsu ND | 2007 | Ann Epidemiol2007，17，12： | 1 |
| 16 | Physician surveys to assess customary care in medical malpractice cases显示文摘 | Hartz A Lucas J Cramm T | 2002 | Journal of General In- ternal Medicine2002，17，： | 1 |
| 17 | Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase]] metabolizing enzyme,GSTpi,at the blood-brain bar- rier显示文摘 | Bauer B Hartz A M Lucking J R | 2008 | J Cereh Blood Flow Metab2008，28，6： | 1 |
| 18 | On-farm assessment of soil quality in California's central valley显示文摘 | Andrews S A Mitchell J P Mancinelli R Karlen D L Hartz T K Horwath W R Pettygrove G S Scow K M Munk D S | | 0，，： | 1 |
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