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| 1 | 化学气体污染突发事件中的人群疏散:横断面调查显示文摘目的比较一个塑料工厂发生化学事故后躲藏和被疏散人群的健康结局。设计横断面调查。背景英格兰西南的市区。研究对象该地区1750位曾暴露于化学烟雾的居民,其中472人被疏散,剩下的1278人被建议躲藏在室内。主要结局测定不利于健康的症状数目。出现4个或以上症状者被确定为一个病例。主要的结果1096位居民(63%;299人被疏散,797人躲藏起来)为本分析提供了资料。被疏散人群的平均症状分值和病例的比例比躲藏人群的要高(疏散者:症状分值1.9,病例比例19.7%(n=59);躲藏者:症状分值1.0,病例比例9.5%(n=76),二者比较P<0.001)。在事故发生后两周末时二组间的差异明显变小。成为病例的两个主要可变更危险因子是疏散(比值比2.5,95%可信区间1.7~3.8)和在事故当天直接暴露于烟雾的时间超过2小时(比值比2.0,95%可信区间1.7~2.3)。住所距工厂的距离或是干预前(头6个小时)暴露的水平对于研究对象成为病例的作用不大。结论在此次化学事故中躲藏起来可能是优于疏散人群的保护措施。这与专家们普遍认为的观点一致。尽管本研究有一定的局限性,但它是基于一场真实的事件。疏散本身有一定的风险和资源上的限制,认识上的增加可能会有助于减少将来不必要的疏散。 | S Kinra G Lewendon R Nelder N Herriott R Mohan M Hort S Harrison V Murray 陈雷(译) | 2005 | 英国医学杂志中文版2005，8，5： | 3 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | Propofol increasesagonist efficacy at the GABAA receptor显示文摘 | O′Shea S M Wong L C Harrison N L | 2000 | Brain Research2000，852，2： | 1 |
| 4 | Uptake of urea C and urea N by the coastal marine diatom 显示文摘 | Price N M Harrison P J | 1988 | Limnol Oceanogr1988，33，： | 1 |
| 5 | Effects of volatileanesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampalneurons显示文摘 | JONES M V HARRISON N L | 1993 | J Neurophysiol1993，70，4： | 1 |
| 6 | Fabrication of photonic crystals for the visible spectrum by holo1graphic lithography显示文摘 | CAMPBELL M SHARP D N HARRISON M T | 2000 | Nature2000，404，6773： | 1 |
| 7 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 8 | The laC- NMR spectra of hemiterpenoid quinoline alkaloids and related prenylquinolines显示文摘 | BROW N GRUNDON M HARRISON D | 1980 | Tetrahedron1980，36，25： | 1 |
| 9 | Vertical nitrite fluxes in the oligotrophic ocean显示文摘 | Lewis M R Harrison W G Oakey N S | 1986 | Science1986，234，： | 1 |
| 10 | Collaborative computational projects显示文摘 | TENNYSON J HARRISON N M | 1994 | Comput Sci News1994，4，： | 1 |
| 11 | Ambient Background Model(ABM):Development of an urban Gaussian dispersion model and its application to London显示文摘 | Seika M Harrison R M Metz N | 1998 | Atmospheric Environment1998，32，11： | 1 |
| 12 | Removal of domestic airborne dust particles by naturally charged liquid sprays 显示文摘 | Gaunt L F Hughes J F Harrison N M | 2003 | Journal of Electrostatics2003，58，15： | 1 |
| 13 | Use of raltitrexed as an alterna- tive to 5-fluorouracil and capecitabine in cancer patients with cardi- ac history显示文摘 | Kelly C Bhuva N Harrison M | 2013 | EurJ Cancer2013，49，10： | 1 |
| 14 | The effect of CO2 availability on the growth, iron oxidation and CO,-fixation rates of pure cultures of Leptospirillum Jerriphilum and Acidithiobacillus Jerrooxidans 显示文摘 | BRYAN C G DAVIS-BELMAR C S van WYK N FRASER M K DEW D RAUTENBACH G F HARRISON | 2012 | Biotechnology and Bioengineering2012，109，7： | 1 |
| 15 | Antecedents to supplier integration in the automotive industry:A multiple-case study of foreign subsidiaries in China显示文摘 | Lockstr6m M Schadel J Harrison N | 2010 | Journal of Operations Management2010，28，3： | 1 |
| 16 | Mineralization in ferritin: An efficient means of iron storage显示文摘 | Chasteen N D Harrison P M | 1999 | J Struct Biol1999，126，： | 1 |
| 17 | The sea spray generation function 显示文摘 | Smith M H Harrison N M | 1998 | Journal of Aerosol Science1998，29，： | 1 |
| 18 | A rapidly enlarging cu- taneous hemangioma in pregnancy 显示文摘 | Ma'ayeh M Purandare N Harrison M | 2014 | ClinPract2014，4，2： | 1 |
| 19 | Mineralization in ferritin: an efficient means of iron storage显示文摘 | CHASTEEN N D HARRISON P M | 1999 | Journal of Structural Biology1999，126，3： | 1 |
| 20 | Use of rahitrexed as an al- ternative to 5-fluorouracil and capeeitabine in cancer patients with cardiac history显示文摘 | Kelly C Bhuva N Harrison M | 2013 | Eur J Cancer2013，49，10： | 1 |
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