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| 1 | Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer显示文摘AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer. | Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto | 2007 | World Journal of Gastroenterology2007，13，21： | 8 |
| 2 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 3 | Vasohibin-1 and vasohibin-2 expression in gastric cancer cells and TAMs显示文摘 | Zhanlong Shen Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2012 | Medical Oncology2012，，4： | 2 |
| 4 | Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents显示文摘 | Pauliina Molander Clas‐G?ran af Bj?rkesten Harri Mustonen Johanna Haapam?ki Matti Vauhkonen Kaija‐Leena Kolho Martti F?rkkil? Taina Sipponen | 2012 | Inflamm Bowel Dis2012，，11： | 2 |
| 5 | Review of fabrication methods of large-area transparent graphene electrodes for industry显示文摘Graphene is a two-dimensional material showing excellent properties for utilization in transparent electrodes;it has low sheet resistance,high optical transmission and is flexible.Whereas the most common transparent electrode material,tin-doped indium-oxide(ITO)is brittle,less transparent and expensive,which limit its compatibility in flexible electronics as well as in low-cost devices.Here we review two large-area fabrication methods for graphene based transparent electrodes for industry:liquid exfoliation and low-pressure chemical vapor deposition(CVD).We discuss the basic methodologies behind the technologies with an emphasis on optical and electrical properties of recent results.State-of-the-art methods for liquid exfoliation have as a figure of merit an electrical and optical conductivity ratio of 43.5,slightly over the minimum required for industry of 35,while CVD reaches as high as 419. | Petri MUSTONEN David MACKENZIE Harri LIPSANEN | 2020 | Frontiers of Optoelectronics2020，13，2： | 1 |
| 6 | Patients with acute pancreatitis complicated by organ failure show highly aberrant monocyte signaling profiles assessed by phospho-specific flow cytometry显示文摘 | Jani Oiva Harri Mustonen Marja-Leena Kyl?np?? Lea Kyh?l? Tiina Alan?r? Saara Aittom?ki Sanna Siitonen Esko Kemppainen Pauli Puolakkainen Heikki Repo | 2010 | Critical Care Medicine2010，，8： | 1 |
| 7 | Macrophage coculture enhanced invasion of gastric cancer cells via TGF-β and BMP pathways显示文摘 | Zhanlong Shen Tuuli Kauttu Jian Cao Hanna Sepp?nen Sanna Vainionp?? Yingjiang Ye Shan Wang Harri Mustonen Pauli Puolakkainen | 2013 | Scandinavian Journal of Gastroenterology2013，，4： | 1 |
| 8 | The novel focal adhesion gene kindlin-2 promotes the invasion of gastriccancer cells mediated by tumor-associated macrophages显示文摘 | Zhanlong Shen Yingjiang Ye Tuuli Kauttu Hanna Sepp?nen Sanna Vainionp?? Shan Wang Harri Mustonen Pauli Puolakkainen | 2013 | Oncology Reports2013，，2： | 1 |
| 9 | Inflammation and disease duration have a cumulative effect on the risk of dysplasia and carcinoma in IBD: A case–control observational study based on registry data显示文摘 | Urpo Nieminen Airi Jussila Stig Nordling Harri Mustonen Martti A. F?rkkil? | 2014 | Int J Cancer2014，，1： | 1 |
| 10 | A randomized comparison of target-controlled propofol infusion and patient-controlled sedation during ERCP显示文摘 | Max Mazanikov Marianne Udd Leena Kyl?np?? Harri Mustonen Outi Lindstr?m Martti F?rkkil? Jorma Halttunen Reino P?yhi? | 2013 | Endoscopy2013，，： | 1 |
| 11 | Long-term results after surgery for gastric cancer with or without jejunal reservoir显示文摘 | Hannu Paimela MD PhD Saara Ketola Mauri Iivonen Timo Tomminen Esa K?n?nen Niku Oksala Harri Mustonen | 2005 | International Journal of Gastrointestinal Cancer2005，，3： | 1 |
| 12 | Long-term results after surgery for gastric cancer with or without jejunal reservoir显示文摘 | Hannu Paimela MD PhD Saara Ketola Mauri Iivonen Timo Tomminen Esa K?n?nen Niku Oksala Harri Mustonen | 2005 | International Journal of Gastrointestinal Cancer2005，，3： | 1 |
| 13 | Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells显示文摘AIM: To assess the effects of ulcerogenic agents on actin cytoskeleton and cell motility and the contribution of oxidative stress.METHODS: Rat gastric mucosal cell monolayers were cultured on coverslips. The cells were exposed, with or without allopurinol (2 mmol/L), for 15 min to ethanol (10-150 mL/L), ASA (1-20 mmol/L) or taurocholate (1-20 mmol/L), then the cells were processed for actin and vinculin staining. Cell migration after wounding was also measured.RESULTS: Exposure to 10 mL/L ethanol caused divergence of zonula adherens-associated actin bundles of adjacent cells and decreased rate of migration. These actions were opposed by xanthine oxidase inhibitor allopurinol. Exposure to 50 mL/L ethanol induced degradation and divergence of zonula adherens-associated vinculin from adjacent cells,which was, again, partially reverted by allopurinol. With 1 mmol/L ASA actin filaments became shorter and thicker.However, higher concentrations (10, 20 mmol/L) of ASA returned microfilaments thinner and longer, and decreased rate of migration. Zonula adherens-associated actin bundles were moderately distorted with 10 mmol/L ASA and with 10 mmol/L taurocholate. Exposure to taurocholate provoked changes resembling those of ASA. Taurocholate 5-20 mmol/L decreased the rate of migration dose dependently. The effects of ASA and taurocholate were not prevented by allopurinol.CONCLUSION: All ulcerogenic agents decreased the rate of migration dose dependently and induced divergence of zonula adherens-associated actin bundles of adjacent cells.In addition, ethanol and ASA caused degradation of actin cytoskeleton. Oxidative stress seems to underlie ethanol,but not ASA or taurocholate, induced cytoskeletal damage. | Siamak Bidel Harri Mustonen Giti Khalighi-Sikaroudi Eero Lehtonen Pauli Puolakkainen Tuula Kiviluoto Eero Kivilaakso | 2005 | World Journal of Gastroenterology2005，11，26： | 0 |
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