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| 1 | Precolumn derivatization LC-MS/MS method for the determination and pharmacokinetic study of glucosamine in human plasma and urine显示文摘A selective precolumn derivatization liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of glucosamine in human plasma and urine has been developed and validated. Glucosamine was derivatized by o-phthalaldehyde/3-mercaptopropionic acid. Chromatographic separation was performed on a Phenomenex ODS column (150 mm 4.6 mm, 5 mm) using linear gradient elution by a mobile phase consisting of methanol (A), and an aqueous solution containing 0.2% ammonium acetate and 0.1% formic acid (B) at a flow rate of 1 mL/min. Tolterodine tartrate was used as the internal standard (IS). With protein precipitation by acetonitrile and then the simple one-step derivatization, a sensitive bio-assay was achieved with the lower limit of quantitation (LLOQ) as low as 12 ng/mL for plasma. The standard addition calibration curves suitable for clinical sample analysis showed good linearity over the range of 0.012-8.27 mg/mL in plasma and 1.80-84.1 mg/mL in urine. The fully validated method has been successfully applied to a pharmacokinetic study of compound glucosamine sulfate dispersible tablets in health Chinese volunteers receiving single oral doses at 500, 1000 and 1500 mg of glucosamine sulfate, as well as multiple oral doses of 500 mg t.i.d. for 7 consecutive days. | Min Songa, Tai-Jun Hanga, Cheng Wanga, Lin Yangb, Ai-Dong Wenb aDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China bDepartment of Pharmacy, Xijing Hospital, Xi’an 710032, China | 2012 | Journal of Pharmaceutical Analysis2012，2，1： | 3 |
| 2 | Clinicocytopathologic study of adenoma malignum of the uterine cervix 显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gynecol Oncol1998，70，2： | 1 |
| 3 | Features and Function of Multiple Evanescent White Dot Syndrome显示文摘 | Hanga I M Masahiro Fujimoto M Yoshimura N | 2009 | Arch Ophthalmol2009，127，10： | 1 |
| 4 | Clinicocytopathologic study of adenoma malignum of the uterine cervix 显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gynecol Oncol1998，70，2： | 1 |
| 5 | Clinicocytopathologic study of adenoma malignum of the uterine cervix 显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gynecol Oncol1998，70，2： | 1 |
| 6 | Clinicocytopathologic study of adenoma malignant of the uterine cervix 显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gynecol Oncol1998，70，2： | 1 |
| 7 | Clinicocytopathologic study of adenoma malignum of the uterine cervix显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gyneeol Oneol1998，70，2： | 1 |
| 8 | Tensile behavior of a new single crystal nickel-based superalloy (CMSX-4) at room and elevated temperatures显示文摘 | SENGUPTA A PUTATUNDA S K BARTOSIEWICZ L HANGAS J NAILOS P J PEPUTAPECK M ALBERTS F E | 1994 | J Mater Eng Perform1994，3，1： | 1 |
| 9 | Precise biopsy localization by computed tomography显示文摘 | HANGA J R ALFIDI R J | 1976 | Radiology1976，118，： | 1 |
| 10 | 显示文摘 | Rimai L Ager R Hangas J | 1993 | J Appl Phys1993，73，： | 1 |
| 11 | Precise biopsy localization by computed tomography显示文摘 | Hanga JR Alfidi RJ | 1976 | Radiology1976，118，： | 1 |
| 12 | Effects of the coexisting diterpenoid tanshinoneson the pharmaco- kinetics of cryptotanshinoneand tanshinone IIa in rat 显示文摘 | Song M Hanga T J Zhanga Z X | 2007 | Eur J Pharm Sci2007，32，45： | 1 |
| 13 | Clinicocytopathologic study of adenoma malignum of the uterine cervix 显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gynecol Oncol1998，70，2： | 1 |
| 14 | Treatment of Suicide Attempters With Bipolar Disorder: A Randomized Clinical Trial Comparing Lithium and Valproate in the Prevention of Suicidal Behavior显示文摘 | Oquendo Maria A Galfalvy Hanga C Currier Dianne Grunebaum Michael F Sher Leo Sullivan Gregory M Burke Ainsley K Harkavy-Friedman Jill Sublette M Elizabeth Parsey Ramin V Mann J John | 2011 | The American Journal of Psychiatry2011，，： | 1 |
| 15 | Clinicocytopathologistudy of ade- nomamalignumo theuterinecervix显示文摘 | Hirai Y Takeshima N Hanga A | 1998 | Gyneco Oncol1998，70，2： | 1 |
| 16 | Deposition of Epitaxially Oriented Films of Cubic Silicon-carbide on Silicon by Laser-ablation-microstructure of the Silicon-silicon-carbide Interface显示文摘 | Rimai L Ager R Weber W H Hangas J Samman A Zhu W | 1995 | Journal of Applied Physics1995，77，12： | 1 |
| 17 | 显示文摘 | Rimai L Ager R Hangas J | 1993 | J Appl Phys1993，73，： | 1 |
| 18 | Tensile behavior of a new single crystal nickel-based superalloy (CMSX-4) at room and elevated temperatures 显示文摘 | SENGUPTA A PUTATUNDA S K BARTOSIEWlCZ L HANGAS J NAILOS P J PEPUTAPECK M ALBERTS F E | 1994 | Journal of Materials Engineering and Performance1994，3，1： | 1 |
| 19 | Better pulmonary function and prognosm with video-assisted thoracic surgery than with thoracotomy显示文摘 | Kaseda S Aoki T Hanga N et a1 | 2000 | Ann Thorac Surg2000，70，5： | 1 |
| 20 | Tensile behavior of a new single crystal nickel-based superalloy (CMSX-4) at room and elevated temperatures显示文摘 | A. Sengupta S. K. Putatunda L. Bartosiewicz J. Hangas P. J. Nailos M. Peputapeck F. E. Alberts | 1994 | Journal of Materials Engineering and Performance1994，，5： | 1 |
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