|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Integrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation显示文摘 | Yong Zhang Lianfeng Gu Yifeng Hou Lulu Wang Xian Deng Runlai Hang Dong Chen Xiansheng Zhang Yi Zhang Chunyan Liu Xiaofeng Cao | 2015 | Cell Research2015，25，7： | 11 |
| 2 | Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina Ⅱ Neurons显示文摘Previous studies have shown that CCL2(C-C motif chemokine ligand 2)induces chronic pain,but the exact mechanisms are still unknown.Here,we established models to explore the potential mechanisms.Behavioral experiments revealed that an antagonist of extracellular signal-regulated kinase(ERK)inhibited not only CCL2-induced inflammatory pain,but also pain responses induced by complete Freund’s adjuvant.We posed the question of the intracellular signaling cascade involved.Subsequent experiments showed that CCL2 up-regulated the expression of phosphorylated ERK(pERK)and N-methyl D-aspartate receptor[NMDAR]subtype 2B(GluN2B);meanwhile,antagonists of CCR2 and ERK effectively reversed these phenomena.Whole-cell patchclamp recordings revealed that CCL2 enhanced the NMDAR-induced currents via activating the pERK pathway,which was blocked by antagonists of GluN2B and ERK.In summary,we demonstrate that CCL2 directly interacts with CCR2 to enhance NMDAR-induced currents,eventually leading to inflammatory pain mainly through the CCL2-CCR2-pERK-GluN2B pathway. | Hui Zhang Sui-Bin Ma Yong-Jing Gao Jun-Ling Xing Hang Xian Zhen-Zhen Li Shu-Ning Shen Sheng-Xi Wu Ceng Luo Rou-Gang Xie | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 3 | Mg-doped ZnO radial spherical structures via chemical vapor deposition显示文摘Mg-doped ZnO radial spherical structures with nanorods grown on both sides of the spherical shell were successfully prepared via chemical vapor deposition (CVD) of Zn and Mg powders in the absence of a catalyst. The structures associated with different growth temperatures (700, 800, and 850°C) were monitored by scanning electron microscopy (SEM), and the result shows that the length of the nanorods increase progressively with the growth temperature increasing. X-ray diffraction (XRD) shows that the as-obtained samples can be indexed to high crystallinity with wurtzite structure. The growth of the nanostructures mainly depends on the formation of sphere-like Mg-doped Zn droplets before adding oxygen. Photoluminescence (PL) spectra that show a 39 meV blue shift indicates that the band gap becomes large, because Mg substitutes Zn in the lattice. | PENG Jiangqiang GUO Jian DING Shulong XU Qiao LI Hang TAN Xuwei ZHAO Xian | 2011 | Rare Metals2011，30，3： | 2 |
| 4 | Research progress in the use of leeches for medical purposes显示文摘Leeches are invertebrates that have a long history of application in the development of human medicine in both the East and the West.This paper comprehensively analyzes and evaluates current research and the latest progress with regard to the application of leeches,their medical value,and their application prospects from various perspectives,so as to provide a reference for new viewpoints and directions for research on leeches.Modern research has revealed that leeches contain various bioactive components,which have pharmacological effects such as anticoagulation,antithrombosis,blood viscosity reduction,and anti-atherosclerosis.Leech therapy is an important treatment approach for venous congestion after microsurgery and is also an effective adjuvant treatment for diabetic feet,chronic pain,and tumors.Therefore,leeches are of importance for the research and development of new drugs,the restoration of blood supply after surgery,and the adjuvant treatment of diseases accompanied by blood blocking.In addition,leeches can also be used as model organisms for research in evolutionary biology and invertebrate neurophysiology as well as in neurophysiological,behavioral,and functional studies. | Chen-Jing Ma Xian Li Hang Chen | 2021 | Traditional Medicine Research2021，6，2： | 2 |
| 5 | Aerosol printing and photonic sintering of bioresorbable zinc nanoparticle ink for transient electronics manufacturing显示文摘Bioresorbable electronics technology can potentially lead to revolutionary applications in healthcare, consumer electronics, and data security. This technology has been demonstrated by various functional devices. However, majority of these devices are realized by CMOS fabrication approaches involving complex and time-consuming processes that are high in cost and low in yield. Printing electronics technology represents a series of printing and post processing techniques that hold promise to make high performance bioresorbable electronics devices. But investigation of printing approaches for bioresorbable electronics is very limited. Here we demonstrate fabrication of conductive bioresorbable patterns using aerosol printing and photonic sintering approaches. Experimental results and simulation reveals that ink compositions, photonic energy, film thickness, and ventilation conditions may influence the effect of photonic sintering. A maximum conductivity of 22321.3 S/m can be achieved using 1 flash with energy of 25.88 J/cm^2 with duration of 2 ms. By combining two cascaded sintering procedures using flash light and laser further improve the conductivity to 34722.2 S/m. The results indicate that aerosol printing and photonic sintering can potentially yield mass fabrication of bioresorbable electronics, leading to prevalence of printable bioresorbable technology in consumer electronics and biomedical devices. | Bikram Kishore MAHAJAN BrANDon LUDWIG Wan SHOU Xiaowei YU Emmanuel FREGENE Hang XU Heng PAN Xian HUANG | 2018 | Science China(Information Sciences)2018，61，6： | 2 |
| 6 | Regulation of the order-disorder phase transition in a Cs_(2)NaFeCl_(6) double perovskite towards reversible thermochromic application显示文摘Multifunctional lead-free double perovskites demonstrate remarkable potential towards applications in various fields.Herein,an environmentally-friendly,low-cost,high-throughput Cs_(2)NaFeCl_(6) single crystal with exceedingly high thermal stability is designed and grown.It obtains a cubic lattice system in the temperature range of 80-500 K,accompanied by a completely reversible chromatic variation ranging from yellow to black.Importantly,the intriguing thermochromism is proved to own extremely high reproducibility(over 1000 cycles)without a hysteretic effect,originating from its structural flexibility that including(i)the noteworthy distortion/deformation of[NaCl_(6)]5−and[FeCl_(6)]3−octahedra;(ii)order-disorder arrangement transition of[NaCl_(6)]5−and[FeCl6]3−octahedra as the function of temperature.This study paves the way towards a new class of smart windows and camouflage coatings with an unprecedented colour range based on a Cs_(2)NaFeCl_(6) perovskite. | Wenzhe Li Naveed Ur Rahman Yeming Xian Hang Yin Yunkai Bao Yi Long Songyang Yuan Yangyi Zhang Yaxuan Yuan Jiandong Fan | 2021 | Journal of Semiconductors2021，42，7： | 2 |
| 7 | Metal-organic frameworks as functional materials for implantable flexible biochemical sensors显示文摘Metal-organic frameworks(MOFs)exhibit attractive properties such as highly accessible surface area,large porosity,tunable pore size,and built-in redox-active metal sites.They may serve as excellent candidates to construct implantable flexible devices for biochemical sensing due to their high thermal and solution stability.However,MOFs-based sensors have only been mostly reported for in-vitro chemical sensing,their use in implantable chemical sensing and combination with flexible electronics to achieve excellent mechanical compatibility with tissues and organs has rarely been summarized.This paper systematically reviews the biochemical sensors based on MOFs and discusses the feasibility to achieve implantable biochemical sensing through MOFs-based flexible electronics.The properties of MOFs and underlying mechanisms have been intrcxluced,followed by a summarization of different biochemical sensing applications.Strategies to integrate MOFs with flexible devices have been supplied from the standpoints of matching mechanics and compatible fabrication processes.Issues that should be addressed in developing flexible MOFs sensors and potential solutions have also been provided,followed by the perspective for future applications of flexible MOFs sensors.This paper may serve as a reference to offer potential guidelines for the development of flexible MOFs-based biochemical sensors that may benefit future applications in personal healthcare,disease diagnosis and treatment,and fundamental study of various biological processes. | Ya Li Wei Ling Xinyu Liu Xue Shang Pan Zhou Zhaorun Chen Hang Xu Xian Huang | 2021 | Nano Research2021，14，9： | 2 |
| 8 | miR‐93/Sp7 function loop mediates osteoblast mineralization显示文摘 | Li Yang Peng Cheng Chao Chen Hong‐Bo He Gen‐Qing Xie Hou‐De Zhou Hui Xie Xian‐Ping Wu Xiang‐Hang Luo | 2012 | J Bone Miner Res2012，，7： | 2 |
| 9 | Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants显示文摘RNA 第二等的结构在基因规定起一个关键作用。瑞斯(Oryza sativa ) 是在世界上的最重要的食物庄稼之一。然而,在米饭的 RNA 结构几乎没被学习。这里,我们成功地产生了在 ? 在米饭的 vivo Structure-seq 图书馆。我们发现 mRNAs 的结构的灵活性可能与生物功能的动力学联系。更高的 N 6-methyladenosine (m 6 一) 修正趋于在 3 UTR 有更少的 RNA 结构,而 GC 内容显著地不影响在 ? 维持象翻译那样的有效生物过程的 vivo mRNA 结构。在米饭和 Arabidopsis 之间的 RNA structurome 的比较分析揭示了内容不导致的那更高的 GC 更强壮的结构和更少 RNA 结构的灵活性。而且,我们发现了在顺序和在米饭和 Arabidopsis 之间的 orthologs 的结构保存之间的弱关联。顺序并且在的保存和分叉 ? vivo RNA 结构对应于多样、特定的生物过程。我们的结果显示那 RNA 第二等的结构可能把选择的分开的层提供给在 monocot 和 dicot 之间的顺序。因此,我们的学习暗示那 RNA 结构在各种各样的生物进程不同地演变在被子植物进化期间在开发和 adaptational 灵活性维持坚韧性。 | Hongjing Deng Jitender Cheema Hang Zhang Hugh Woolfenden Matthew Norris Zhenshan Liu Qi Liu Xiaofei Yang Minglei Yang Xian Deng Xiaofeng Cao Yiliang Ding | 2018 | Molecular Plant2018，11，4： | 2 |
| 10 | miR‐148a regulates osteoclastogenesis by targeting V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B显示文摘 | Peng Cheng Chao Chen Hong‐Bo He Rong Hu Hou‐De Zhou Hui Xie Wu Zhu Ru‐Chun Dai Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2013 | J Bone Miner Res2013，，5： | 1 |
| 11 | Modeling and validation for electromagnetic mechanical synchronous resonance via wireless power transmission显示文摘 | Zhang Xian Su Hang Zhang Pengcheng | 2015 | IEEE Transactions on Magnetics2015，51，3： | 1 |
| 12 | MiR‐503 Regulates Osteoclastogenesis via Targeting RANK显示文摘 | Chao Chen Peng Cheng Hui Xie Hou‐De Zhou Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2014 | J Bone Miner Res2014，，2： | 1 |
| 13 | Effects of a chemically derived homo zwitterionic polysaccharide on immune activation in mice显示文摘在这研究,一个化学上修改的人两性离子的多糖(ZPS ) , sulfated chitosan,被用来在鼠科的有免疫力的反应上检验它的效果。结果证明 homoZPS 能显著地支持两个脾的 T/B 房间和粘合剂房间的增长。特别地,流动 cytometry 试金证明 sulfated chitosan 能非明确地在 vitro 激活 CD3+ 和 CD8+ T 房间增长。助手作为抗原并且与铝氢氧化物的相比用牛的浆液白朊(BSA ) 和白喉毒素(DT ) 被测试的 sulfated chitosan 的有效性。到 BSA 和 DT 的特定的抗体的层次显著地在 homoZPS 种痘以后增加了。homoZPS 和铝氢氧化物助手能对 DT 的攻击保护老鼠免受怒气的浮肿的伤害并且跟踪。现在的调查结果证明化学上导出的 homoZPS 能是在 T 淋巴细胞依赖疫苗的助手的发展的一个潜在的候选人。 | Chun Meng Xu Peng Xian'ai Shi Hang Wang Yanghao Guo | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 1 |
| 14 | An approach to the method for determination of surface potential on solid/liquid interface: theory显示文摘 | Hang Li Chang Le Qing Shi Qiang Wei Xian Jun Jiang | 2004 | Journal of Colloid And Interface Science2004，，1： | 1 |
| 15 | The protective effect of carnosic acid on dextran sulfate sodium-induced colitis based on metabolomics and gut microbiota analysis显示文摘Accumulating evidence suggests that the gut microbiota plays an important role in the pathogenesis of inflammatory bowel disease(IBD).Carnosic acid(CA)is a major antioxidant component of rosemary and sage.Herein,we investigated the protective effects of dietary CA on dextran sodium sulfate(DSS)-induced colitis mouse model with an emphasis on its impact on the composition and metabolic function of gut microbiota.We found that CA effectively attenuated DSS-stimulated colitis in mice,as evidenced by reduced disease activity index(DAI),and systemic and colonic inflammation.Additionally,CA restored microbial diversity and improved the composition of gut microbiota in DSS-treated mice.Moreover,Spearman’s correlation coefficient showed a significant correlation between the fecal metabolites and the gut microbiota species.Changes in gut microbiota and the correlated metabolites might partially explain CA’s anti-inflammatory effects against colitis.Future clinical trials are needed to determine the therapeutic effects and mechanisms of CA on IBD in humans. | Changhui Du Zhenjie Li Jing Zhang Ni Yin Lirong Tang Jie Li Jingyin Sun Xiaoqing Yu Wei Chen Hang Xiao Xian Wu Xuexiang Chen | 2023 | Food Science and Human Wellness2023，12，4： | 1 |
| 16 | Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice显示文摘 | WANG JY XIAN XD HANG W | 2007 | Arterioscler Thromb Vasc Biol2007，27，1： | 1 |
| 17 | Liver dynamic contrast‐enhanced MRI for staging liver fibrosis in a piglet model显示文摘 | Li Zhou Tian‐wu Chen Xiao‐ming Zhang Zhi Yang Hong‐jie Tang Dan Deng Nan‐lin Zeng Li‐ying Wang Xiao‐li Chen Hang Li Chun‐ping Li Li Li Xian‐yong Xie Jiani Hu | 2014 | J. Magn. Reson. Imaging2014，，4： | 1 |
| 18 | Prevalence of Acne Inversa(Hidradenitis Suppurativa)in China:A Nationwide Cross-Sectional Epidemiological Study显示文摘Objective:This study was performed to estimate the prevalence of hidradenitis suppurativa(HS)in China and describe the demographic and clinical features of HS in the Chinese population.Methods:This multicenter clinic-based cross-sectional study was conducted in dermatology clinics within 19 hospitals located in 15 cities/provinces across China from September to October 2020.The prevalence of HS was calculated as the percentage of patients with HS among all visitors at participating clinics during the 1-month study period.HS was independently diagnosed by two certified dermatologists at each site.All visitors at participating clinics were screened,and all patients with HS were invited to participate in a questionnaire survey to elucidate the demographics and clinical features of HS in the Chinese population.Results:We identified 92 patients with HS among 274,742 visitors at participating clinics.The prevalence rate was 0.03349%or 33.49 per 100,000 population(95%confidence interval,26.64–40.32),and the female:male ratio was 1.0:4.7.Conclusion:The overall prevalence of HS in China was lower than that in Western and other Asian countries with a predominance of male patients. | Zhong-Shuai Wang Jing Li Qiang Ju Wei Lai Song-Mei Geng Xiao-Jing Kang Xian Jiang Hong-Zhong Jin Hong-Fu Xie Qing Sun Hang Li Shan-Shan Li Chen Yuan Li He Hong Fang Gang Wang Juan Tao Xing-Hua Gao Yan Wu You-Kun Lin Yu-Zhen Li Jun Gu Yan Yan Baoxi Wang | 2022 | International Journal of Dermatology and Venereology2022，5，1： | 1 |
| 19 | An updated classification for the hyper-diverse genus Corydalis(Papaveraceae: Fumarioideae)based on phylogenomic and morphological evidence显示文摘The genus Corydalis, with ca. 530 species, has long been considered taxonomically challenging because of its great variability. Previous molecular analyses,based on a few molecular markers and incomplete taxonomic sampling, were clearly inadequate to delimit sections and subgenera. We have performed phylogenetic analyses of Corydalis and related taxa,using 65 shared protein-coding plastid genes from313 accessions(including 280 samples of ca. 226species of Corydalis) and 152 universal low-copy nuclear genes from 296 accessions(including 271samples of Corydalis) covering all 42 previously recognized sections and five independent “series”.Phylogenetic trees were inferred using Bayesian Inference and Maximum Likelihood. Eight selected morphological characters were estimated using ancestral state reconstructions. Results include:(i) of the three subgenera of Corydalis, two are fully supported by both the plastid and nuclear data;the third,subg. Cremnocapnos, is weakly supported by plastid DNA only, whereas in the nuclear data the two included sections form successive outgroups to the rest of the genus;(ii) among all 42 sections and five“series”, 25 sections and one “series” are resolved as monophyletic in both data sets;(iii) the common ancestor of Corydalis is likely to be a perennial plant with a taproot, yellow flowers with a short saccate spur, linear fruits with recurved fruiting pedicels, and seeds with elaiosomes;(iv) we provide a new classification of Corydalis with four subgenera(of which subg. Bipapillatae is here newly described), 39 sections, 16 of which are consistent with the previous classification, 16 sections have been recircumscribed, one section has been reinstated and six new sections are established. Characters associated with lifespan, underground structures, floral spur, fruit and elaiosomes are important for the recognition of subgenera and sections. These new phylogenetic analyses combined with ancestral character reconstructions uncovered previously unrecognized relationships, and greatly improved our understanding of the evolution of the genus. | Jun‐Tong Chen Magnus Lidén Xian‐Han Huang Liang Zhang Xin‐Jian Zhang Tian‐Hui Kuang Jacob BLandis Dong Wang Tao Deng Hang Sun | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 20 | Burden of Outpatient Visits Attributable to Ambient Temperature in Qingdao,China显示文摘Climate change has been referred to as one of the greatest threats to human health,with reports citing likely increases in extreme meteorological events.In this study,we estimated the relationships between temperature and outpatients at a major hospital in Qingdao,China,during 2015–2017,and assessed the morbidity burden.The results showed that both low and high temperatures were associated with an increased risk of outpatient visits. | WANG Zi Xian CHENG Yi Bin WANG Yu WANG Yan ZHANG Xin Hang SONG He Jia LI Yong Hong YAO Xiao Yuan | 2021 | Biomedical and Environmental Sciences2021，34，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员