|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Nutrient Enrichment in Tropical Wetlands:Shifts from Autotrophic to Heterotrophic Nitrogen Fixation显示文摘 | HanaˇS Eliˇska R Barbora P | 2010 | Biogeochemistry2010，，101： | 1 |
| 3 | Insulin pumps in pediatricroutine care improve Long - term metabolic controc without increasing the risk of hypoglycenria显示文摘 | Hanas R Adolfsson P | 2006 | Pediatr Diabetes2006，7，1： | 1 |
| 4 | CSII in children with diabetes显示文摘 | Hanas R | 2005 | Acta Biomed2005，76，3： | 1 |
| 5 | Diabetic ketoscidosis ( DKA ) : treatment guidelines显示文摘 | Rosembloom AL Hanas R | 1996 | Clin Pediatr1996，35，5： | 1 |
| 6 | Brain Natriuretic Pep- tide and N-Terminal proBNP in Chronic Haemodialysis Patients 显示文摘 | Jaroslav R Hana K Ladislav T | 2006 | Nephron Clin Pract2006，103，4： | 1 |
| 7 | Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia 显示文摘 | Hanas R Adolfsson P | 2006 | Pediatr Diabetes2006，7，1： | 1 |
| 8 | 2010 Consensus statement on the worldwide standardization of the hemoglobin A1c measurement显示文摘 | Hanas R John G International HbA1c Consensus Committee | 2010 | Clin Chem Lab Med2010，48，： | 1 |
| 9 | Lipid Remodeling of Murine Epididymosomes and spermatozoa during epididyal maturation 显示文摘 | Hanae R Benoit S Gerard P | 2006 | Biol Reprod2006，74，6： | 1 |
| 10 | 2010 consensus statement on the worldwide standardization of the hemoglobin Alc measurement 显示文摘 | Hanas R John G | 2010 | Clin Chem2010，56，8： | 1 |
| 11 | Blood glucose and beta - hydroxybutyrate responses when the insulin pump is stopped in children and adolescents显示文摘 | Hanas R Lundqvist K Windell L el al | 2006 | Pediatr Diabetes2006，7，5： | 1 |
| 12 | Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver显示文摘 | van de Steeg Evita Stránecky Viktor Hartmannová Hana Nosková Lenka Hrebícek Martin Wagenaar Els van Esch Anita de Waart Dirk R Elferink Ronald P J Oude Kenworthy Kathryn E Sticová Eva al-Edreesi Mohammad Knisely A S Kmoch Stanislav Jirsa Mi | 2012 | EN2012，，2： | 1 |
| 13 | Thyrnolipoma: clues to pathogenesis revealed by cytogenetics显示文摘 | Hudacko R Aviv Hana Langenfeld J | 2009 | Ann Diagn Pathol2009，13，3： | 1 |
| 14 | Characterization of fatty acids and triacylglycerols in vegetable oils bygas chromatography and statistical analysis 显示文摘 | Tomas Rˇ ezanka Hana Rˇ ezankova | 1999 | Analytica Chimica Acta1999，398，： | 1 |
| 15 | Insulin pumps in pediatricr outine care improve Long - term metabolic controc without increasing the risk of hypoglycenria 显示文摘 | Hanas R Adolfss on P | 2006 | Pediatr Diabetes2006，7，1： | 1 |
| 16 | Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents显示文摘 | Hanas R Ludvigsson J | 2006 | Pediatr Diabetes2006，7，4： | 1 |
| 17 | Retrospective analysis of 25 women with malignant cystosarcoma phyllodes—treatment results显示文摘 | Renata Soumarová Zuzana ?eneklová Hana Horová Hana Vojkovská Ivana Horová Marie Budíková Jana R??i?ková Barbara Je?ková | 2004 | Archives of Gynecology and Obstetrics2004，，4： | 1 |
| 18 | Metastases of esophageal carcinoma to skeletal muscle:Single center experience显示文摘Metastases of esophageal carcinoma to the skeletal muscle are rare,but the incidence may be increasing because of better diagnosis resulting from widespread use of positron emission tomography/computed tomography(PET/CT).A cohort of 205 patients with esophageal carcinoma treated at our center who had PET/CT between 2006 and 2010 was retrospectively evaluated for the presence of skeletal muscle metastases.Four patients had skeletal muscle metastases of esophageal carcinoma,including two patients with squamous cell carcinoma.In another patient with squamous cell carcinoma of the esophagus and synchronous skeletal muscle metastases,muscle metastases were subsequently shown to be related to second primary pancreatic adenocarcinoma.In all cases,skeletal muscle metastases were the first manifestation of systemic disease.In three patients palliation was obtained with the combination of external beam radiation therapy,systemic chemotherapy or surgical resection.Skeletal muscle metastases are a rare complication of esophageal carcinoma. | Jan Cincibuch Miroslav Myslivecek Bohuslav Melichar estmír Neoral Iva Metelková Michaela Zezulová Hana Procházková-tudentová Patrik Flodr Miloslava Zlevorová René Aujesky Karel Cwiertka | 2012 | World Journal of Gastroenterology2012，18，35： | 1 |
| 19 | Sorption of dyes from aqueous solutions onto fly ash 显示文摘 | Pavel J Hana B Milena R | 2003 | Water Res2003，37，2： | 1 |
| 20 | Hypoglycemia and ketoacidosis-with in sulin pump therapy in children and ado lescents显示文摘 | Hanas R Ludvigsson J | 2006 | Pediatr diabetes2006，14，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员