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| 1 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 4 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 5 | Cardioprotective effects of Guanxinshutong (GXST) against myocardial ischemia/ reperfusion injury in rats显示文摘对 cardioprotective 药的灌注损害的 BackgroundThe 保护的效果最近被评估了并且发现了不适当。Guanxinshutong (GXST ) ,传统的植物的联合和蒙古的药,在在临床的试用对待心绞痛有效、安全。我们在老鼠对心肌的局部缺血和灌注(MI/R ) 损害估计 GXST 的 cardioprotective 效果并且探索它的可能的 mechanism.MethodsForty -- 五只男 Sprague Dawley 老鼠被使随机化进三个组:non-MI/R 组(假冒, n = 15 ) ,与车辆对待的 MI/R 组(控制, n = 15 ) 并且与 GXST 对待的 MI/R 组(药, n = 15 ) 。MI/R 被左前面的下降冠的动脉(男孩) 的结扎导致 30 分钟,在控制和药组由 2/24 小时灌注列在后面。在假冒的组,没有吸藏, LAD 被暴露。GXST 粉末(在药组) 或盐(在控制和假冒的组) 在外科以前从 7 白天经由直接胃的 gavage 被管理。血样品从颈动脉动脉被收集(10 只老鼠各组织) 在 2 小时灌注以后,决定肿瘤坏死 factor-α 的层次;(TNF-α) , interleukin-1β(IL-1β) , interleukin-6 (IL-6 ) 和用连接酶的 immunosorbent 试金的细胞间的粘附 molecule-1 (ICAM-1 ) 。动物然后被牺牲,心为组织病理学说和西方的污点分析被收获。梗塞尺寸在留下被测量在在 24 小时 reperfusion.ResultsGXST 以后的每个组的五只老鼠显著地减少了 TNF-α 的层次;, IL-1β, IL-6, ICAM-1, apoptosis 索引(AI ) 和梗塞缩放。GXST 显然也禁止了原子因素 kappa B (NF-κ B ) 活动什么时候与控制组相比(所有 P <0.05 ).ConclusionsGXST 在在老鼠保护心肌层免于 MI/R 损害是有效的。它的可能的 cardioprotective 机制包含煽动性的反应和 apoptosis 追随者 MI/R 损害的抑制。 | Zhuo Llang Li-Feng Llu Tian-Ming Yao Yu Huo Ya-Ling Han | 2012 | Journal of Geriatric Cardiology2012，9，2： | 13 |
| 6 | Structural insights into the TRIM family of ubiquitin E3 ligases显示文摘 | Yang Li Han Wu Wei Wu Wei Zhuo Weixiao Liu Yixiao Zhang Minzhang Cheng Ye-Guang Chen Ning Gao Hongtao Yu Linfang Wang Wei Li Maojun Yang | 2014 | Cell Research2014，24，6： | 12 |
| 7 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 8 | Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart显示文摘This work characterizes the mitochondrial proteomic profile in the failing heart and elucidates the molecular basis of mitochondria in heart failure. Heart failure was induced in rats by myocardial infarction, and mitochondria were isolated from hearts by differential centrifugation. Using two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry, a system biology approach was employed to investigate differences in mitochondrial proteins between normal and failing hearts. Mass spectrometry identified 27 proteins differentially expressed that involved in energy metabolism. Among those, the up-regulated proteins included tricarboxylic acid cycle enzymes and pyruvate dehydrogenase complex subunits while the down-regulated proteins were involved in fatty acid oxidation and the OXPHOS complex. These results suggest a substantial metabolic switch from free fatty acid oxidation to glycolysis in heart failure and provide molecular evidence for alterations in the structural and functional parameters of mitochondria that may contribute to cardiac dysfunction during ischemic injury. | WANG Jun1,2, BAI Ling1,2, LI Jing3, SUN ChaoFeng1,2, ZHAO Jin1, CUI ChangCong1,2, HAN Ke1,2, LIU Yu1,2, ZHUO XiaoZhen1,2, WANG TingZhong1,2, LIU Ping1,2, FAN FenLing1,2, GUAN YouFei3 & MA AiQun1,2 1 Department of Cardiology, First affiliated hospital of medical college of Xi’an Jiaotong University, Xi’an 710061, China 2 Ion Channel Disease Laboratory, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry, Xi’an 710061, China 3 Department of Physiology and Pathophysiology Key Laboratory of Molecular Cardiovascular Sciences of the Ministry of Education, Peking University Health Science Center, Beijing 100083, China | 2009 | Science China(Life Sciences)2009，52，11： | 10 |
| 9 | Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells显示文摘稀释 Listeria monocytogenes (LM ) 是为癌症疫苗的交货的有希望的候选人向量。在由介绍抗原的房间的吞噬作用以后,这个细菌刺激主要 histocompatibility 建筑群(MHC ) 我和 MHC-II 小径并且导致抗原特定的 T 淋巴细胞的增长。包含复制缺乏的 LM 种类 Δ 的基因修正的新策略; dalΔ dat (Lmdd ) 被开发了表示并且藏匿人的 CD24 蛋白质。CD24 是仔细与 hepatocellular 癌(HCC ) 的 apoptosis,转移和复发被联系的肝的癌症干细胞 biomarker。在在老鼠的静脉内的管理以后, Lmdd-CD24 首先在怒气和肝被散布并且没引起严重机关损害。Lmdd-CD24 有效地增加了干扰素(IFN ) 的数字 -γ-producing CD8 + T 房间和 IFN-γ分泌物。Lmdd-CD24 也提高了 IL-4- 和 IL-10-producing T 助手 2 房间的数字。Lmdd-CD24 疫苗的功效进一步对 Hepa1-6-CD24 肿瘤被调查,它腹股沟地被接种进老鼠。Lmdd-CD24 显著地在老鼠减少了肿瘤尺寸并且增加了他们的幸存。尤其是, T 规章的房间(Treg ) 的减小数并且特定的 CD8 +T 房间活动的改进在渗入肿瘤的淋巴细胞(TIL ) 被观察。这些结果对 HCC 建议 Lmdd-CD24 疫苗的一个潜在的应用程序。 | Yu Yang Jiajie Hou Zhe Lin Han Zhuo DianyuChen Xudong Zhang Yun Chen Beicheng Sun | 2014 | Cellular & Molecular Immunology2014，11，2： | 9 |
| 10 | Two-micrometer thulium laser resection of the prostate-tangerine technique in benign prostatic hyperplasia patients with previously negative transrectal prostate biopsy显示文摘前列腺橘子技术(TmLRP-TT ) 的 2-m 铥激光切除术为良性的 prostatic 增生(BPH ) 作为最低限度地侵略的治疗被介绍了。这研究被承担与以前否定的 transrectal 前列腺活体检视为 BPH 病人的治疗估计 TmLRP-TT 的临床的功效和安全。用 TmLRP-TT 经历了外科的治疗的有以前否定的 transrectal 前列腺活体检视的 51 个病人的未来的分析从 2011 年 12 月被执行到 2013 年 12 月。外科手术前的地位,外科的细节,和 perioperative 复杂并发症被记录。后续结果在 1 和 6 个月与主观、客观的测试被评估。TmLRP-TT 成功地在所有病人被完成。吝啬的前列腺体积,起作用的持续时间,和 catheterization 时间是 93.3 ? ??????? | Jian Zhuo Hai-Bin Wei Fei Zhang Hai-Tao Liu Fu-Jun Zhao Bang-Min Han Xiao-Wen Sun Jun-Lu Shu-Jie Xia | 2017 | Asian Journal of Andrology2017，19，2： | 8 |
| 11 | A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer显示文摘The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer(CRC). This is mainly due to the immunosuppressive feature of the tumor microenvironment(TME). Emerging evidence reveals that certain chemotherapeutic drugs induce immunogenic cell death(ICD), demonstrating great potential for remodeling the immunosuppressive TME. In this study, the potential of ginsenoside Rg3(Rg3) as an ICD inducer against CRC cells was confirmed using in vitro and in vivo experimental approaches. The ICD efficacy of Rg3 could be significantly enhanced by quercetin(QTN) that elicited reactive oxygen species(ROS). To amelioratein vivo delivery barriers associated with chemotherapeutic drugs, a folate(FA)-targeted polyethylene glycol(PEG)-modified amphiphilic cyclodextrin nanoparticle(NP) was developed for co-encapsulation of Rg3 and QTN. The resultant nanoformulation(CD-PEG-FA.Rg3.QTN) significantly prolonged blood circulation and enhanced tumor targeting in an orthotopic CRC mouse model, resulting in the conversion of immunosuppressive TME. Furthermore, the CD-PEG-FA.Rg3.QTN achieved significantly longer survival of animals in combination with Anti-PD-L1. The study provides a promising strategy for the treatment of CRC. | Dandan Sun Yifang Zou Liu Song Shulan Han Hao Yang Di Chu Yun Dai Jie Ma Caitriona M.O’Driscoll Zhuo Yu Jianfeng Guo | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 8 |
| 12 | Differences of Hydrocarbon Enrichment between the Upper and the Lower Structural Layers in the Tazhong Paleouplift显示文摘Tazhong paleouplift 被划分成上面并且更低的结构的层,在奥陶纪碳酸盐岩石的顶由不顺从表面跳了。在从不同部分的二层的水库在数字变化,类型和储备,而是机制以前很少被研究。因此,机制的解释将在 Tazhong paleouplift 支持石油探索。在学习进化和 Tazhong paleouplift 的水库分发以后,在晚古苏格兰的、迟了的 Hercynian 和喜玛拉雅的时期的进化导致了,这被结束上面并且更低的结构的层。这也被定义在上面的结构的层,结构并且, stratigraphic 重叠水库为更低的结构的层在顶和 paleouplift 的上面的部分被开发,它被油水库统治, lithological 水库在 paleouplift 的更低的部分被开发,它被煤气的水库,和更多统治储备在更低的结构的层被发现比上面。通过累积条件的比较分析上面并且更低的结构的层,丰富差别的机制清楚地被解释。更低的结构的层的水库和封口条件比上面的层的那些好,它是更多的水库在前者被发现了的原因。在搬运人系统类型,陷井类型和收费时期在之间的差别上面并且更低的结构的层在水库类型和分布导致差别。一个累积模型为 Tazhong paleouplift 被建立。为上面的结构的层,,结构的水库和 stratigraphic 重叠水库为更低的结构的层在 paleouplift 的上面的部分被形成,捱过的外壳水库在顶被形成,礁石公寓水库在侧面的边缘上被形成,石灰岩地区常见的地形和里面水库在 paleouplift 的更低的部分被形成。 | JIANG Zhenxue YANG Haijun LI Zhuo PANG Xiongqi HAN Jianfa LI Dongxu HUANG Yuyan | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 13 | A Network Traffic Prediction Method Based on LSTM显示文摘As the network sizes continue to increase,network traffic grows exponentially.In this situation,how to accurately predict network traffic to serve customers better has become one of the issues that Internet service providers care most about.Current traditional network models cannot predict network traffic that behaves as a nonlinear system.In this paper,a long short-term memory(LSTM)neural network model is proposed to predict network traffic that behaves as a nonlinear system.According to characteristics of autocorrelation,an autocorrelation coefficient is added to the model to improve the accuracy of the prediction model.Several experiments were conducted using real-world data,showing the effectiveness of LSTM model and the improved accuracy with autocorrelation considered.The experimental results show that the proposed model is efficient and suitable for real-world network traffic prediction. | WANG Shihao ZHUO Qinzheng YAN Han LI Qianmu QI Yong | 2019 | ZTE Communications2019，17，2： | 6 |
| 14 | Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure显示文摘Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF).We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload.The reversible effect of these changes with bisoprolol was also evaluated.The HF group exhibited left ventricular enlargement,systolic dysfunction,prolongation of corrected QT interval (QTc),and increased plasma brain natriuretic peptide levels in the HF rabbits.Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits.After bisoprolol treatment,heart function was improved significantly and QTc was shortened.Additionally,the mRNA expression of potassium channel subunit genes could be partially reversed.The down-regulated expression of potassium channel subunits Kv4.3,Kv1.4,KvLQT1,minK and Kir 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF.Bisoprolol could partially reverse these down-regulations and improve heart function. | Xi Li Tingzhong Wang Ke Han Xiaozhen Zhuo Qun Lu Aiqun Ma | 2011 | The Journal of Biomedical Research2011，25，4： | 6 |
| 15 | An indicator-guided photo-controlled drug delivery system based on mesoporous silica/gold nanocomposites显示文摘mesoporous 硅石 / 黄金(MSN/Au ) nanocomposite 为明确地目标为肿瘤房间的控制相片的药交货被设计。MSN/Au nanocomposite 由基于 MSN 的药搬运人组成,金 nanoparticle (AuNP ) 基于指示物。当基于 MSN 的药搬运人是 mesoporous 硅石时, nanoparticle 与相片可切换的偶氮苯使不能调动(偶氮) 一半,基于 AuNP 的指示物是与矩阵 metalloproteinase (MMP ) 修改的熄灭荧光的 AuNP 底层并且 poly (乙烯乙二醇) 。二种 nanoparticles 被连接由一, cyclodextrin (, CD ) 更暗淡的桥牌。在 vitro,研究证明 nanocomposite 明确地与肿瘤地点 overexpressing MMP-2 交往了,为释放的随后的紫外轻照耀的启用的指导它骗诱药。通过基于 AuNP 的指示物和基于 MSN 的药搬运人的集成, MSN/Au nanocomposite 能精确本地化释放的药到肿瘤地点,显著地从而改进治疗学的功效。 | Guofeng Luo Weihai Chen Huizhen Jia Yunxia Sun Han Cheng Renxi Zhuo Xianzheng Zhang | 2015 | Nano Research2015，8，6： | 6 |
| 16 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 17 | Analyses of risk factors and prognosis for new-onset atrial fibrillation in elderly patients after dual-chamber pacemaker implantation显示文摘Objective To retrospectively identify risk factors and the prognosis for new-onset atrial fibrillation (AF)after implantation of dual-chamber pacemakers in elderly patients.Methods Consecutive patients aged >65years who underwent their first implantation of a dual-chamber permanent pacemaker in Beijing Anzhen Hospital from October 2013to May 2016were enrolled.Their complete program- ming and follow-up data were recorded.Follow-up end points included new-onset AF and major adverse cardiovascular and cerebrovascular events.Restdts Altogether,322patients were enrolled,with new-onset AF observed in 79(24.5%)during their follow-up.Multivariable analysis identified four independent predictors of new-onset AF in elderly patients after pacemaker implantation:hypertension (HR =3.040, 95%CI:1.09-3.05,P =0.00),age (HR =1.966,95%CI:1.57-3.68,P =0.01);left atrial enlargement (HR =1.645,95%CI:1.05-1.25,P = 0.03);high ventricular pacing rate (HR =1.137,95%CI:1.01-1.06,P =0.01).Univariable analysis indicated that the CHA2DS2-VASc score was also a risk factor for AF (HR =1.368,95%CI:1.178-1.589,P =0.002),whereas multivariable regression analysis did not. Kaplan-Meier survival analysis showed that the risk for ischemic stroke was significantly higher in the new-onset AF group than in the non-AF group (P <0.05).Conclusion Hypertension,age,left atrial enlargement,and high ventricular pacing rate were independent predictors of new-onset AF in elderly patients after implantation of a permanent pacemaker.New-onset AF increased the risk for ischemic stroke. | Xiao-Li CHEN Xue-Jun REN Zhuo LIANG Zhi-Hong HAN Tao ZHANG Zhi LUO | 2018 | Journal of Geriatric Cardiology2018，15，10： | 5 |
| 18 | Realizing high low-electric-field energy storage performance in AgNbO_(3) ceramics by introducing relaxor behaviour显示文摘Both sustainable development in environment and safety of high-power systems require to develop a novel lead-free dielectric capacitor with high energy density(Wrec)at low applied electric field.In this work,a remarkably high Wrec of 2.9 J/cm^(3) accompanying with energy storage efficiency of 56% was achieved in Ag_(0.9)Sr_(0.05)NbO_(3) ceramic at a low applied electric field of 190 kV/cm,by improving antiferroelectricity and introducing relaxor behaviour.The improved anti-ferroelectric stability was attributed to the decreased tolerance factor and average electronegativity difference,while the relaxor behaviour was associated with the increased disordered local structure by Sr-doping.Moreover,the Ag_(0.9)Sr_(0.05)NbO_(3) ceramics also exhibited outstanding temperature stability in energy density with small variation less than 5% over 20-140℃.The results indicate that the Ag_(0.9)Sr_(0.05)NbO_(3) ceramic is a promising candidate for low-electric-field driving capacitors. | Kai Han Nengneng Luo Shuaifei Mao Fangping Zhuo Xiyong Chen Laijun Liu Changzheng Hu Huanfu Zhou Xinpeng Wang Yuezhou Wei | 2019 | Journal of Materiomics2019，5，4： | 5 |
| 19 | Novel miniature mobile cardiac catheterization laboratory for critical cardiovascular disease following natural disasters: a feasibility study显示文摘 | HAN Ya-ling LIANG Zhuo YAO Tian-ming SUN Jing-yang LIANG Ming HUO Yu WANG Geng, WANG Xiao-zeng LIANG Yan-chun MENG Wei-hong | 2012 | Chinese Medical Journal2012，，6： | 5 |
| 20 | PyWRKY26 and PybHLH3 cotargeted the PyMYB114 promoter to regulate anthocyanin biosynthesis and transport in red-skinned pears显示文摘Red pear is favored because of its bright appearance and abundant anthocyanins.Anthocyanin biosynthesis is controlled by transcription factors(TFs)forming regulatory complexes.In red-skinned pears,the WRKY TFs have a significant relationship with anthocyanin biosynthesis,but the molecular mechanism of the WRKY TFs involved in regulating color formation in red-skinned pear is unclear.In this study,the TFs PyWRKY31 and PyWRKY26 were screened as candidate genes for controlling anthocyanin biosynthesis by transcriptome data and bioinformatics analysis.The effect of anthocyanin accumulations after cotransformation of PyWRKY31 or PyWRKY26 with its partners PyMYB10,PyMYB114,and PybHLH3 was verified in tobacco leaves and strawberry receptacles by a transient expression system.RT-qPCR analysis and a dual-luciferase reporter system further confirmed that this cotransformation activated the expression of PyDFR,PyANS,and PyUFGT in anthocyanin biosynthesis and PyGST in anthocyanin transport instead of the PyABC transporter and PyAVP.Furthermore,the cotransformed PyWRKY26 and PybHLH3 could bind to the PyMYB114 promoter,and PyWRKY26 directly activated the transcription of PyMYB114.In addition,the TF PyWRKY26 could interact with PybHLH3,as confirmed by firefly luciferase complementation and yeast two-hybrid(Y2H)assays.These results showed that the interaction of PyWRKY26 and PybHLH3 could cotarget the PyMYB114 promoter,which resulted in anthocyanin accumulation in red-skinned pear.This study further strengthened the understanding of the regulatory mechanism of anthocyanin accumulation and contributed to improving the appearance of red-skinned pears. | Chuang Li Jun Wu Kang-Di Hu Shu-Wei Wei Hong-Ye Sun Lan-Ying Hu Zhuo Han Gai-Fang Yao Hua Zhang | 2020 | Horticulture Research2020，7，1： | 5 |
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