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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Formation of a dense and continuous AI2O3 layer in nano thermal barrier coating systems for the suppression of spinel growth on the AI2O3 oxide scale during oxidation 显示文摘 | DAROONPARVAR M YAJ1D MUHAMAD A M YUSOF N M HUSSAIN MOHAMMAD S RAD HAMID R B | 2013 | Journal of Alloys and Compounds2013，571，： | 1 |
| 4 | Simple method for the determination of 5-aminosalieylic and N- acetyl-5-aminosalicylie acid in rectal tissue biopsies 显示文摘 | HUSSAIN F N AJJAN R A MOUSTAFA M | 1998 | J Chromatography B1998，716，： | 1 |
| 5 | Ru(Ⅲ) analogue of model methane monooxygenase in the effective catalytic oxidation of cyclohexane by molecular oxygen显示文摘 | HUSSAIN A SHUKLA R S THORAT R B | 2003 | J Mol Catal A: Chem2003，193，： | 1 |
| 6 | Relationship between biomechanical changes at adjacent segments and number of fused bone grafts in multilevel cervical fusions: a finite element investigation 显示文摘 | Hussain M Nassr A Natarajan R N | 2014 | J Neurosurg Spine2014，20，1： | 1 |
| 7 | Common fixed-point results in best approximation theory显示文摘 | HUSSAIN N KHAN A R | 2003 | Applied Math Letter2003，16，： | 1 |
| 8 | Cross-talk be tween NFkB and the PI3-kinase/AKT pathway can be targe- ted in primary effusion lymphoma(PEL) cell lines for effi cient apoptosis显示文摘 | Hussain A R Ahmed S O Ahmed M | 2012 | PLoS One2012，7，39： | 1 |
| 9 | Postpartum uterine flora following normal and abnormal puerperium in cows显示文摘 | Hussain A M Daniel R C W Oboyle O | 1990 | Theriogenology1990，34，： | 1 |
| 10 | Transpupillary thermotherapy for chronic central serous chorioretinopathy 显示文摘 | Hussain N Khanna R Hussain A | 2006 | Graefes Arch Clin Exp Ophthalmol2006，244，8： | 1 |
| 11 | Soil compac- tion: A role for ethylene in regulating leaf expansion and shoot growth in tomato? 显示文摘 | Hussain A Black C R Taylor I B | 1999 | Plant Physiology1999，121，4： | 1 |
| 12 | Effect of encapsulated calcium carbide on growth,yield and n use efficiency of rice (ORYZA SATIVA L)显示文摘 | YASEEN M HUSSAIN S A KASHIF S R | 2009 | Pak J Bot2009，41，4： | 1 |
| 13 | Prognostic factors in patients with surgically resected stagesⅠandⅡnonsmall cell lung cancer显示文摘 | JAZIEH A R HUSSAIN M HOWINGTON J A | 2000 | Ann Thorac Surg2000，70，4： | 1 |
| 14 | Unambiguous Carbon - 13 NMR assignments of some biologically active protoberberine alkaloids 显示文摘 | HUSSAIN R A KIM J W BEECHER C W | 1989 | Heterocycles1989，29，12： | 1 |
| 15 | A new approach for measurement of cytotoxicity using colorimetric assay显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 16 | Social and economic considerations in conserving wetlands of Indo-gangetie Plains: A ease study of kabartal wetland, India显示文摘 | Ambastha K Hussain S A Badola R | 2007 | Environmentalist2007，，27： | 1 |
| 17 | Reduced TNF-alpha and IFN-gamma responses to Central Asian strain 1 and Beijing isolates of Mycobacterium tuberculosis in comparison with H37Rv strain显示文摘 | Tanveer M Hasan Z Kanji A Hussain R Hasan R | 2009 | Trans R Soc Trop Med Hyg2009，103，6： | 1 |
| 18 | A new approach for measurement of cytotoxicity using colorimetric assay 显示文摘 | Hussain R F Nouri A M Oliver R T | 1993 | J Immunol Methods1993，160，1： | 1 |
| 19 | Impacts of tillage and no-till on production of maize and soybean on an eroded Illinois silt loam soil显示文摘 | Hussain I Olson K R Ebelhar S A | 1999 | Soil & Tillage Research1999，52，： | 1 |
| 20 | Popliteal artery entrapment syn- drome presenting with acute limb isehaemia: a case report 显示文摘 | Soobrah R Nawaz A Hussain T | 2010 | Case Report Med2010，，： | 1 |
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