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| 1 | Enhanced rectification, transport property and photocurrent generation of multilayer ReSe2/MoS2 p-n heterojunctions显示文摘 | Xiaoting Wang Le Huang Yuting Peng Nengjie Huo Kedi Wu Congxin Xia Zhongming Wei Sefaattin Tongay Jingbo Li | 2016 | Nano Research2016，9，2： | 16 |
| 2 | Observational study of the circulation in the southern South China Sea显示文摘CTD data from two oceanographic survey cruises, conducted by 'Shiyan No.3' R/V during two reversing monsoons, were employed to calculate and analyze the distributions of temperature, salinity and geopotential anomaly in the southern South China Sea (SSCS). Based on these distributions, the horizontal structures of the SSCS circulation are described systematically. Study results show that the SSCS circulation structure could be classified as a two-layer (the upper and the lower) pattern, and that the main circulation in the upper layer (0-400 m) is driven by the South China Sea monsoons and is opposite in direction to the reversal of the monsoons. The distributions of principal current systems and their features are presented. Two important local phenomena, local eddy and oceanic front, were observed. | Fang Wendong Guo Zhongxin Huang Yuting | 1998 | Chinese Science Bulletin1998，43，11： | 13 |
| 3 | mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3b/MMPs显示文摘Golgi membrane protein 1(GOLM1/GP73)is a serum marker of hepatocellular carcinoma(HCC).We have previously shown that mTOR promoted tumorigenesis of HCC through stimulating GOLM1 expression.In this study,we demonstrated that the mammalian target of rapamycin(mTOR)was a negative regulator of microRNA-145(miR-145)expression.miR-145 inhibited GOLM1 expression by targeting a coding sequence of GOLM1 gene.GOLM1 and miR-145 were inversely correlated in human HCC tissues.GOLM1-enriched exosomes activated the glycogen synthase kinase-3β/matrix metalloproteinases(GSK-3β/MMPs)signaling axis of recipient cells and accelerated cell proliferation and migration.In contrast,miR-145 suppressed tumorigenesis and metastasis.We suggest that mTOR/miR-145/GOLM1 signaling pathway should be targeted for HCC treatment. | Xiaochen Gai Bufu Tang Fangming Liu Yuting Wu Fang Wang Yanling Jing Fuqiang Huang Di Jin Ling Wang Hongbing Zhang | 2019 | Journal of Genetics and Genomics2019，46，5： | 13 |
| 4 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 5 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 6 | Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblasti显示文摘B-cell precursor acute lymphoblastic leukemia(BCP-ALL)is characterized by genetic alterations with high heterogeneity.Precise subtypes with distinct genomic and/or gene expression patterns have been recently revealed using high-throughput sequencing technology.Most of these profiles are associated with recurrent non-overlapping rearrangements or hotspot point mutations that are analogous to the established subtypes,such as DUX4 rearrangements,MEF2D rearrangements,ZNF384/ZNF362 rearrangements,NUTM1 rearrangements,BCL2/MYC and/or BCL6 rearrangements,ETV6-RUNX1-like gene expression,PAX5alt(diverse PAX5 alterations,including rearrangements,intragenic amplifications,or mutations),and hotspot mutations PAX5(p.Pro80Arg)with biallelic PAX5 alterations,IKZF1(p.Asn159Tyr),and ZEB2(p.His1038Arg).These molecular subtypes could be classified by gene expression patterns with RNA-seq technology.Refined molecular classification greatly improved the treatment strategy.Multiagent therapy regimens,including target inhibitors(e.g.,imatinib),immunomodulators,monoclonal antibodies,and chimeric antigen receptor T-cell(CAR-T)therapy,are transforming the clinical practice from chemotherapy drugs to personalized medicine in the field of risk-directed disease management.We provide an update on our knowledge of emerging molecular subtypes and therapeutic targets in BCP-ALL. | Jianfeng Li Yuting Dai Liang Wu Ming Zhang Wen Ouyang Jinyan Huang Saijuan Chen | 2021 | Frontiers of Medicine2021，15，3： | 6 |
| 7 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 8 | Quantitative evaluation of DNA damage caused by atmospheric and room-temperature plasma (ARTP) and other mutagenesis methods using a rapid umu-microplate test protocol for microbial mutation breeding显示文摘Mutagenesis is an important technique for microbial mutation breeding.As the source of mutations,DNA damage extent is a key indicator for the effectiveness of mutagenesis.Therefore,a rapid and easy DNA damage quantification method is required for the comparison of mutagenesis effects and development of mutagenesis tools.Here,we used the umu-microplate test system to quantitatively compare the DNA damage strength caused by atmospheric and room-temperature plasma(ARTP)and other traditional mutagenesis methods including:ultraviolet radiation(UV),diethyl sulfate(DES)and 4-nitroquinoline-1-oxide(4-NQO).The test strain of Salmonella typhimurium TA1535/pSK1002 was used to monitor the time-course profile of b-galactosidase activity induced by DNA damage caused by different mutagenesis methods using a microplate reader.The umu-microplate test results showed that ARTP caused higher extent of DNA damage than UV and chemical mutagens,which agrees well with the result obtained by SOS-FACS-based quantification method as reported previously.This umu-microplate test is accessible for broad researchers who are lack of the expensive FACS instruments and allows the quick quantitative evaluation of DNA damage among living cells for different mutagenesis methods in the study of the microbial mutation breeding. | Yuting Huang Liyang Wang Xue Zhang Nan Su Heping Li Yoshimitsu Oda Xinhui Xing | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 4 |
| 9 | Purely organic optoelectronic materials with ultralong-lived excited states under ambient conditions显示文摘The exponential growth of utilizing synthetic organic molecules in optoelectronic applications poses strong demands for rational control over the excited states of the materials. The manipulation of excited states through molecular design has led to the development of high-performance optoelectronic devices with tunable emission colors, high quantum efficiencies and efficient energy/charge transfer processes. Recently, a significant breakthrough in lifetime tuning of excited states has been made;the purely organic molecules were found to have ultralonglived excited state under ambient conditions with luminescence lifetimes up to 1.35 s, which are several orders of magnitude longer than those of conventional organic fluorophores. Given the conceptual advance in understanding the fundamental behavior of excited state tuning in organic luminescent materials, the investigations of organic ultralong room-temperature phosphorescence(OURTP) should provide new directions for researches and have profound impacts on many different disciplines. Here, we summarized the recent understandings on the excited state tuning, the reported OURTP molecules and their design considerations,the spectacular photophysical performance, and the amazing optoelectronic applications of the newly emerged organic optoelectronic materials that free of heavy metals. | Jie Yuan Yuting Tang Shen Xu Runfeng Chen Wei Huang | 2015 | Science Bulletin2015，60，19： | 4 |
| 10 | Engineering rock mechanics practices in the underground powerhouse at JinpingⅠhydropower station显示文摘Based on the analyses of data obtained from the underground powerhouse at Jinping Ⅰ hydropower station,a comprehensive review of engineering rock mechanics practice in the underground powerhouse is first conducted.The distribution of strata,lithology,and initial geo-stress,the excavation process and corresponding rock mass support measures,the deformation and failure characteristics of the surrounding rock mass,the stress characteristics of anchorage structures in the cavern complex,and numerical simulations of surrounding rock mass stability and anchor support performance are presented.The results indicate that the underground powerhouse of Jinping Ⅰ hydropower station is characterized by high to extremely high geo-stresses during rock excavation.Excessive surrounding rock mass deformation and high stress of anchorage structures,surrounding rock mass unloading damage,and local cracking failure of surrounding rock masses,etc.,are mainly caused by rock mass excavation.Deformations of surrounding rock masses and stresses in anchorage structures here are larger than those found elsewhere:20%of extensometers in the main powerhouse record more than 50 mm with the maximum at around 250 mm observed in the downstream sidewall of the transformer hall.There are about 25%of the anchor bolts having recorded stresses of more than 200 MPa.Jinping Ⅰ hydropower plant is the first to have an underground powerhouse construction conducted in host rocks under extremely high geo-stress conditions,with the ratio of rock mass strength to geo-stress of less than 2.0.The results can provide a reference to underground powerhouse construction in similar geological conditions. | Aiqing Wu Jimin Wang Zhong Zhou Shuling Huang Xiuli Ding Zhihong Dong Yuting Zhang | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，5： | 4 |
| 11 | Identification and differentiation of major components in three different “Sheng-ma” crude drug species by UPLC/Q-TOF-MS显示文摘Cimicifugae Rhizoma(Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China,has been widely used in traditional Chinese medicine.The Pharmacopoeia of the People's Republic of China contains three varieties(Cimicifuga dahurica(Turcz.),Cimicifuga foetida L.and Cimicifuga heracleifolia Kom.) which have been used clinically as 'Sheng-ma'.However,the chemical constituents of three components of 'Sheng-ma' have never been documented.In this study,a rapid method for the analysis of the main components of 'Sheng-ma' was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry(UPLC/Q-TOF-MS).The present study reveals the major common and distinct chemical constituents of C.dahurica,C.foetida and C.heracleifolia and also reports principal component and statistical analyses of these results.The components were identified by comparing the retention time,accurate mass,mass spectrometric fragmentation characteristic ions and matching empirical molecular formula with that of the published compounds.A total of 32 common components and 8 markers for different 'Sheng-ma' components were identified.These findings provide an important basis for the further study and clinical utilities of the three 'Sheng-ma' varieties. | Mengxue Fan Kunming Qin Fei Ding Yuting Huang Xiaoli Wang Baochang Cai | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 4 |
| 12 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 13 | Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome显示文摘Dear Editor, Most disease-associated genomic mutations are base substitutions and approximately half of pathogenic human single nucleotide polymorphisms (SNPs)are related to C-to-T substitutions in the ClinVar database.Base editors (BEs),which combine Casg-DIOA nickase and APOBEC (apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like)or AID (activation-induced deaminase)cytidine deaminase family members, have been successfully applied to mediate C-to-T conversion in vitro and in vivo, providing a powerful tool to model or repair diseaserelated human SNPs. | Jianan Li Zhen Liu Shisheng Huang Xiao Wang Guanglei Li Yuting Xu Wenxia Yu Shanshan Chen Yu Zhang Hanhui Ma Zunfu Ke Jia Chen Qiang Sun Xingxu Huang | 2019 | Cell Research2019，29，2： | 3 |
| 14 | INTERFERENCE BY NON-HOST PLANT ROOTS AND ROOT EXUDATES IN THE INFECTION PROCESSES OF PHYTOPHTHORA NICOTIANAE显示文摘Crop rotations are widely used because they can significantly reduce the incidence of pests and diseases.The interactions between non-host roots and pathogens may be key in the inhibition of soilborne pathogens in crop rotations.Interactions between fennel(Foeniculum vulgare)roots/root exudates and Phytophthora nicotianae were investigated because of the known allelopathy between fennel and tobacco(Nicotiana tabacum).The effects of the key compounds in the fennel rhizosphere on the mycelial growth and zoospore behavior of P.nicotianae were assessed.The roots of fennel attracted P.nicotianae zoospores and inhibited their motility and the germination of cystospores,with some cystospores rupturing.4-ethylacetophenone,vanillin and N-formylpiperidine were consistently identified in the fennel rhizosphere and were found to interfere with the infection of P.nicotianae,especially vanillin.Hyphae treated with these compounds produced more abnormal branches and accumulated reactive oxygen species.These interspecific interactions between non-host roots and pathogens were found to be an important factor in the inhibition by fennel of infection by P.nicotianae. | Yuxin YANG He ZHANG Yuting FANG Ying LI Xinyue MEI Huichuan HUANG Fei DU Shusheng ZHU Min YANG Yixiang LIU | 2021 | Frontiers of Agricultural Science and Engineering2021，8，3： | 3 |
| 15 | Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells显示文摘Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found that CMA was inhibited in MSCs in response to the proinflammatory cytokines interferon-γ(IFN-γ)and tumor necrosis factor-α(TNF-α).In addition,suppression of CMA by knocking down the CMA-related lysosomal receptor lysosomal-associated membrane protein 2(LAMP-2A)in MSCs significantly enhanced the immunosuppressive effect of MSCs on T cell proliferation,and as expected,LAMP-2A overexpression in MSCs exerted the opposite effect on T cell proliferation.This effect of CMA on the immunosuppressive function of MSCs was attributed to its negative regulation of the expression of chemokine C-X-C motif ligand 10(CXCL10),which recruits inflammatory cells,especially T cells,to MSCs,and inducible nitric oxide synthase(iNOS),which leads to the subsequent inhibition of T cell proliferation via nitric oxide(NO).Mechanistically,CMA inhibition dramatically promoted IFN-γplus TNF-α-induced activation of NF-κB and STAT1,leading to the enhanced expression of CXCL10 and iNOS in MSCs.Furthermore,we found that IFN-γplus TNF-α-induced AKT activation contributed to CMA inhibition in MSCs.More interestingly,CMA-deficient MSCs exhibited improved therapeutic efficacy in inflammatory liver injury.Taken together,our findings established CMA inhibition as a critical contributor to the immunosuppressive function of MSCs induced by inflammatory cytokines nd highlighted a previously unknown function of CMA. | Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang | 2021 | Cellular & Molecular Immunology2021，18，6： | 3 |
| 16 | A dual-luciferase reporter system for characterization of small RNA target genes in both mammalian and insect cells显示文摘MicroRNAs(miRNAs)are regulatory RNA molecules that bind to target messenger RNAs(mRNAs)and affect the stability or translational efficiency of the bound mRNAs.Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells.These reporter systems,however,are not sensitive enough to verify miRNA-target gene relationships in insect cell lines because the promoters of the target luciferase(usually Renilla)used in these reporter systems are too weak to drive sufficient expression of the target luciferase in insect cells.In this study,we replaced the SV40 promoter in the psiCHECK-2 reporter vector,which is widely used with mammalian cell lines,with the HSV-TK or AC5.1 promoter to yield two new dual-luciferase reporter vectors,designated psiCHECK-2-TK and psiCHECK-2-AC5.1,respectively.Only psiCHECK-2 and psiCHECK-2-AC5.1 had suitable target(7?enz7/a)/reference(firefly)luciferase activity ratios in mammalian(HeLa and HEK293)and insect(Sf9,S2,Helicoverpa zea fat body and ovary)cell lines,while psiCHECK-2-TK had suitable Renilla/firefly luciferase activity ratios regardless of the cell line.Moreover,psiCHECK-2-TK successfully detected the interaction between Helicoverpa armigera miRNA9a and its target,the 3'-untranslated region of heat shock protein 90,in both mammalian and H.zea cell lines,but psiCHECK-2 failed to do so in IT.zea cell lines.Furthermore,psiCHECK-2-TK with the target sequence,HzMasc(H.zea Masculinizer),accurately differentiated between H.zea cell lines with or without the negative regulation factor(miRNA or piRNA)of HzMasc.These data demonstrate that psiCHECK-2-TK can be used to functionally characterize small RNA target genes in both mammalian and insect cells. | Zhongyuan Deng Yuting Zhang Leyao Li Xingcheng Xie Jinyong Huang Min Zhang Xinzhi Ni Xianchun Li | 2022 | Insect Science2022，29，3： | 2 |
| 17 | 中国西南地区不同海拔高度在1961–2014年间极端高温趋势变化显示文摘本研究根据中国气象局最近发布的中国高分辨率气象站的日最高气温和平均气温观测数据,分析了中国西南地区在1961–2014年间极端高温的趋势。中国西南不同海拔地区的极端高温趋势在近50年间(1961–2014)呈现出阶段性变化。平均温度和最高温度的变化趋势也表现出相对应的变化。这些与温度有关的变量在1975–94年期间均缓慢增加,而在最近的1995–2014年期间则急剧增加,增幅约为1975–94年的2–10倍。这种加速的增加主要发生在中、高海拔地区,并且最高温度比平均温度上升得快得多。而这一时期正是众所周知的全球变暖间歇期。这一结果表明,我国内陆高海拔区域的气温变化趋势可能与全球平均气温变化有明显差异。 | XUE Yuting CHEN Quanliang ZHANG Jiayu HUANG Ping | 2020 | Atmospheric and Oceanic Science Letters2020，13，5： | 2 |
| 18 | Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action显示文摘 | Huaning Wang Ruiguo Zhang Yuting Qiao Fen Xue Huang Nie Ying Wang Zhengwu Peng Qingrong Tan | 2014 | Behavioural Brain Research2014，，： | 2 |
| 19 | Earthquake detection in the Jiangsu region, China using graphics-processing-unit-based Match & Locate and rapid earthquake association and location显示文摘Earthquake detection and location are essential in earthquake studies,which generally consists of two main classes:waveform-based and pick-based methods.To evaluate the ability of two different methods,a graphicsprocessing-unit-based Match&Locate(GPU-M&L)method and a rapid earthquake association and location(REAL)method are applied to continuous seismic data recorded by 24 digital seismic stations from Jiangsu Seismic Network during 2013 for comparison.GPU-M&L is one of waveform-based methods by waveform cross-correlations while REAL is one of pick-based method to associate arrivals of different seismic phases and locate events through counting the number of P and S picks and travel time residuals.Twenty-six templates are selected from the Jiangsu Seismic Network local catalog by using the GPU-M&L.The number of newly detected and located events is about 2.8 times more than those listed in the local catalog.We both utilize a deep-neural-network-based arrival-time picking method called PhaseNet and a shortterm/long-term average(STA/LTA)trigger algorithm for seismic phase detection and picking by applying the REAL.We then refine seismic locations using a least-squares location method(VELEST)and a high-precision relative location method(hypoDD).By applying STA/LTA and PhaseNet,1006 and 1893 events are associated and located,respectively.The newly detected events are mainly clustered and show steeply dipping fault planes.By analyzing the performance of these methods based on long-term continuous seismic data,the detected catalogs by the GPU-M&L and REAL show that the magnitudes of completeness are 1.4 and 0.8,respectively,which are smaller than 2.6 given by the local catalog.Although REAL provides improvement compared with GPU-M&L,REAL is highly dependent on phase detection and picking which is strongly affected by signal-noise ratio(SNR).Stations at southeast of the study region with low SNR may lead to few detections in the same area. | Yafen Huang Shengzhong Zhang Yuejun Lv Yanzhen Li Yuting Zhang Min Liu | 2020 | Earthquake Science2020，33，1： | 2 |
| 20 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
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