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| 1 | Clinical features and treatment status of hemifacial spasm in China显示文摘 | Wang Lin Hu Xingyue Dong Hongjuan Wang Wenzhao Huang Yue Jin Lingjing Luo Yumin Zhang Weixi Lian Yajun Liang Zhanhua Shang Huifang Feng Yabo wu Yiwen Chen Jun Luo Weifeng Wan Xinhua | 2014 | Chinese Medical Journal2014，，5： | 20 |
| 2 | Biological productivity and carbon cycling in the Arctic Ocean显示文摘Primary production, bacterial production, par-ticulate organic carbon fluxes and organic carbon burial rates were quantified during the summer period of 1999 in the Arctic Ocean via 14C uptake, 3H uptake, 234Th/238U disequilibrium and 210Pbex dating, respectively. The integrated primary production in the water column was as high as 197 mmolC/(m2·d) in the Chukchi shelf and was 3.8 mmolC/(m2·d) in the Canada Basin. These rates are higher than those reported previously. The ratios of bacterial production to primary production in the study region were higher than 0.5, indicating that microbial activity is not depressed but important in cold Arctic waters. 234Th/238U dis-equilibria were evident at the station in the Canada Basin. The presence of significant 234Th deficiency suggested that scavenging and removal processes are also important to bio-geochemical cycles of trace elements in the Arctic Ocean. Particulate organic carbon export flux was estimated to be 1.0 mmolC/(m2·d). Measurements of sediment | CHEN Min HUANG Yipu GUO Laodong CAI Pinghe YANG Weifeng LIU Guangshan QIU Yusheng | 2002 | Chinese Science Bulletin2002，47，12： | 17 |
| 3 | Occupant evacuation model based on cellular automata in fire显示文摘By applying the rules set in traffic flow and pedestrian flow models, a basic cellular automata model is presented to simulate occupant evacuation in fire. Some extended models are introduced to study the special phenomena of evacuation from the fire room. The key of the models is the introduction of the danger grade which makes the route choice convenient and reasonable. Fire not only influences the emotional and behavioral characteristics of an individual but also affects his physical constitution, which reduces his maximal possible velocity. The models consider these influence factors by applying a set of simple but effective rules. It is needed to emphasize that all rules are established according to the essential phenomenon in fire evacuation, that is, all the occupants would try to move to the safest place as fast as possible. Some simulation examples are also presented to validate the applicability of the models. | Lizhong Yang Weifeng Fang Rui Huang Zhihua Deng | 2002 | Chinese Science Bulletin2002，47，17： | 16 |
| 4 | Cellular automata pedestrian movement model considering human behavior显示文摘The pedestrian movement is more complex than vehicular flow for the reason that people are more flexible and intelligent than car. Without the limit of 搇anes?pedestrian movement is loose and free. Furthermore, they are easily affected by other walkers as well as the environ-ment around. In this paper some special technique is intro-duced considering human behavior to make the rules more reasonable. By simulating the two-dimension pedestrian movement, the phase transition phenomena of pedestrian movement, including the up walkers moving from the bottom to the upper boundary and the right walkers moving from the left to the right boundary, are presented. Studying on the effect of the system size on the critical density shows that the critical density is independent of the system size in the scope studied in this paper. | YANG Lizhong, FANG Weifeng, LI Jian, HUANG Rui & FAN Weicheng State Key Laboratory of Fire Science, University of Science and Tech-nology of China, Hefei 230026, China Correspondence should be addressed to Yang Lizhong (e-mail:zxd@ustc. edu.cn) | 2003 | Chinese Science Bulletin2003，48，16： | 16 |
| 5 | Influence Analysis of Secondary O-ring Seals in Dynamic Behavior of Spiral Groove Gas Face Seals显示文摘The current research on secondary O-ring seals used in mechanical seals has begun to focus on their dynamic properties. However, detailed analysis of the dynamic properties of O-ring seals in spiral groove gas face seals is lacking. In particular a transient study and a difference analysis of steady-state and transient performance are imperative. In this paper, a case study is performed to gauge the effect of secondary O-ring seals on the dynamic behavior(steady-state performance and transient performance) of face seals. A numerical finite element method(FEM) model is developed for the dynamic analysis of spiral groove gas face seals with a flexibly mounted stator in the axial and angular modes. The rotor tilt angle, static stator tilt angle and O-ring damping are selected to investigate the effect of O-ring seals on face seals during stable running operation. The results show that the angular factor can be ignored to save time in the simulation under small damping or undamped conditions. However, large O-ring damping has an enormous effect on the angular phase difference of mated rings, affecting the steady-state performance of face seals and largely increasing the possibility of face contact that reduces the service life of face seals. A pressure drop fluctuation is carried out to analyze the effect of O-ring seals on the transient performance of face seals. The results show that face seals could remain stable without support stiffness and O-ring damping during normal stable operation but may enter a large-leakage state when confronting instantaneous fluctuations. The oscillation-amplitude shortening effect of O-ring damping on the axial mode is much greater than that on the angular modes and O-ring damping prefers to cater for axial motion at the cost of angular motion. This research proposes a detailed dynamic-property study of O-ring seals in spiral groove gas face seals, to assist in the design of face seals. | HU Songtao HUANG Weifeng LIU Xiangfeng WANG Yuming | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 14 |
| 6 | The effect of surface roughness on thermal-elasto-hydrodynamic model of contact mechanical seals显示文摘In this paper,the effect of surface roughness on sealing clearance,pressure distribution,friction torque and leakage is studied by the thermal-elasto-hydrodynamic mixed lubrication model.A convergent nominal clearance is formed by the pressure deformation and thermal deformation of the seal faces.This causes more serious wear in the inner side than that of the outer side of the contact area.Mass leakage increases with the growing of the surface roughness.The temperature and thermal deformation on the seal surface increases substantially if the roughness is reduced.The contact mechanical seals have consistent performance when the standard deviation of surface roughness is approximately 0.2μm.In order to validate the theoretical analysis model,a method combining the measurement of three-dimensioned profile and Raman spectrum is proposed. | WEN QingFeng LIU Ying HUANG WeiFeng SUO ShuangFu WANG YuMing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，10： | 13 |
| 7 | A New Critical Nitrogen Dilution Curve for Rice Nitrogen Status Diagnosis in Northeast China显示文摘In-season diagnosis of crop nitrogen(N) status is crucial for precision N management. Critical N(N_c) dilution curve and N nutrition index(NNI) have been proposed as effective methods to diagnose N status of different crops. The N_c dilution curves have been developed for indica rice in the tropical and temperate zones and japonica rice in the subtropical-temperate zone, but they have not been evaluated for short-season japonica rice in Northeast China. The objectives of this study were to evaluate the previously developed N_c dilution curves for rice in Northeast China and to develop a more suitable N_c dilution curve in this region. A total of17 N rate experiments were conducted in Sanjiang Plain, Heilongjiang Province in Northeast China from 2008 to 2013. The results indicated that none of the two previously developed N_c dilution curves was suitable to diagnose N status of the short-season japonica rice in Northeast China. A new N_c dilution curve was developed and can be described by the equation N_c = 27.7 W^(-0.34) if W ≥ 1 Mg dry matter(DM) ha^(-1) or N_c = 27.7 g kg^(-1) DM if W < 1 Mg DM ha^(-1), where W is the aboveground biomass. This new curve was lower than the previous curves. It was validated using a separate dataset, and it could discriminate non-N-limiting and N-limiting nutritional conditions. Additional studies are needed to further evaluate it for diagnosing N status of different rice cultivars in Northeast China and develop efficient non-destructive methods to estimate NNI for practical applications. | HUANG Shanyu MIAO Yuxin CAO Qiang YAO Yinkun ZHAO Guangming YU Weifeng SHEN Jianning YU Kang Georg BARETH | 2018 | Pedosphere2018，28，5： | 10 |
| 8 | Fluid-solid Interaction Model for Hydraulic Reciprocating O-ring Seals显示文摘Elastohydrodynamic lubrication characteristics of hydraulic reciprocating seals have significant effects on sealing and tribology performances of hydraulic actuators,especially in high parameter hydraulic systems.Only elastic deformations of hydraulic reciprocating seals were discussed,and hydrodynamic effects were neglected in many studies.The physical process of the fluid-solid interaction effect did not be clearly presented in the existing fluid-solid interaction models for hydraulic reciprocating O-ring seals,and few of these models had been simultaneously validated through experiments.By exploring the physical process of the fluid-solid interaction effect of the hydraulic reciprocating O-ring seal,a numerical fluid-solid interaction model consisting of fluid lubrication,contact mechanics,asperity contact and elastic deformation analyses is constructed with an iterative procedure.With the SRV friction and wear tester,the experiments are performed to investigate the elastohydrodynamic lubrication characteristics of the O-ring seal.The regularity of the friction coefficient varying with the speed of reciprocating motion is obtained in the mixed lubrication condition.The experimental result is used to validate the fluid-solid interaction model.Based on the model,The elastohydrodynamic lubrication characteristics of the hydraulic reciprocating O-ring seal are presented respectively in the dry friction,mixed lubrication and full film lubrication conditions,including of the contact pressure,film thickness,friction coefficient,liquid film pressure and viscous shear stress in the sealing zone.The proposed numerical fluid-solid interaction model can be effectively used to analyze the operation characteristics of the hydraulic reciprocating O-ring seal,and can also be widely used to study other hydraulic reciprocating seals. | LIAO Chuanjun HUANG Weifeng WANG Yuming SUO Shuangfu LIU Ying | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 10 |
| 9 | Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain显示文摘The present study was designed to examine the therapeutic effects of Botulinum neurotoxin A(BoNT/A)on depression-like behaviors in mice and to explore the potential mechanisms.These results revealed that a single facial injection of BoNT/A induced a rapid and prolonged improvement of depression-like behaviors in naive and space-restriction-stressed(SRS)mice,reflected by a decreased duration of immobility in behavioral despair tests.BoNT/A significantly increased the 5-hydroxytryptamine(5-HT)levels in several brain regions,including the hippocampus and hypothalamus,in SRS mice.BoNT/A increased the expression of the N-methyl-Daspartate receptor subunits NR1 and NR2 B in the hippocampus,which were significantly decreased in SRS mice.Furthermore,BoNT/A significantly increased the expression of brain-derived neurotrophic factor(BDNF)in the hippocampus,hypothalamus,prefrontal cortex,and amygdala,which were decreased in SRS mice.Finally,BoNT/A transiently increased the levels of phosphorylated extracellular signal-regulated kinase(p-ERK)and cAMPresponse element binding protein(p-CREB),which were suppressed in the hippocampus of SRS mice.Collectively,these results demonstrated that BoNT/A treatment has antidepressant-like activity in mice,and this is associated with increased 5-HT levels and the activation of BDNF/ERK/CREB pathways in the hippocampus,supporting further investigation of BoNT/A therapy in depression. | Yang Li Jing Liu Xu Liu Cun-Jin Su Qi-Lin Zhang Zhi-Hong Wang Lei-Fang Cao Xue-Yan Guo Ya Huang Weifeng Luo Tong Liu | 2019 | Neuroscience Bulletin2019，35，4： | 10 |
| 10 | Thermal Fluid-Solid Interaction Model and Experimental Validation for Hydrostatic Mechanical Face Seals显示文摘Hydrostatic mechanical face seals for reactor coolant pumps are very important for the safety and reliability of pressurized-water reactor power plants.More accurate models on the operating mechanism of the seals are needed to help improve their performance.The thermal fluid–solid interaction(TFSI)mechanism of the hydrostatic seal is investigated in this study.Numerical models of the flow field and seal assembly are developed.Based on the mechanism for the continuity condition of the physical quantities at the fluid–solid interface,an on-line numerical TFSI model for the hydrostatic mechanical seal is proposed using an iterative coupling method.Dynamic mesh technology is adopted to adapt to the changing boundary shape.Experiments were performed on a test rig using a full-size test seal to obtain the leakage rate as a function of the differential pressure.The effectiveness and accuracy of the TFSI model were verified by comparing the simulation results and experimental data.Using the TFSI model,the behavior of the seal is presented,including mechanical and thermal deformation,and the temperature field.The influences of the rotating speed and differential pressure of the sealing device on the temperature field,which occur widely in the actual use of the seal,are studied.This research proposes an on-line and assembly-based TFSI model for hydrostatic mechanical face seals,and the model is validated by full-sized experiments. | HUANG Weifeng LIAO Chuanjun LIU Xiangfeng SUO Shuangfu LIU Ying WANG Yuming | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 10 |
| 11 | Numerical and experimental analysis of the reusability of spring energized metal C rings显示文摘It is well known that static seals are usually designed to be used once.In this paper,we discuss the reusability of a type of static seal called the spring energized metal C ring,which is required to be reused 4–5 times without maintenance during the lifetime of the pump.A theoretical analysis based on the nonlinear finite element method and an experimental investigation of the reusability of the C ring are carried out.The effects of the elastic modulus of the ring material,the ring wall thickness,the amount of assembly interference between the spring and the C ring,the operating temperature and the compression ratio are discussed.The parameter S,which denotes the reaction force difference percentage,is determined to measure the reusability of the C ring.The results show that the ring wall thickness plays an important role in the reusability.Although the normal force of a thick wall decreases after the ring is reused eight times,the value is still higher than the first normal force of a thin wall.In contrast,the elastic modulus of the material has the lowest impact.Here,a pre-compression ratio of 18.2%not only produces a larger first normal force but also leads to a smaller reduction in the normal force when the ring is reused.A simulated experiment is carried out to investigate the influence of the coating of the C ring on its reusability.The results show that when plastic deformation occurs on the contact surface,the contact state of the C ring coating becomes a major factor that affects the seal performance.Aging treatment at high temperatures(250°C)reduces the binding force of the silver coating on the spring energized metal C ring,which leads to the deterioration in the reusability of the ring. | LIU Ying ZHOU Kun HUANG WeiFeng GAO Zhi WANG YuMing | 2014 | Science China(Technological Sciences)2014，57，8： | 9 |
| 12 | Fluid-solid strong-interaction model of mechanical seals in reactor coolant pumps显示文摘The studies on the mechanisms and performances of the mechanical seals in reactor coolant pumps are very important for the safe operations of the pressurized water reactor power plants.Based on the hydrostatic mechanical seal in reactor coolant pumps,an analytical fluid-solid strong-interaction model is proposed in this paper.According to the design features and operational principles of the seal,an analytical method to calculate the mechanical deformation of the seal assembly is developed based on the ring deformation theory.A strong-interaction algorithm combining the analysis of the mechanical deformation of the seal assembly and flow field between the seal faceplates is utilized,in which the three kinds of equations including the fluid domain,solid domain and coupling action are constituted in the same equations set and all the variables are solved simultaneously.So the analytical fluid-solid strong-interaction model used for the seal is built.Moreover,the model is verified by the experimental results.Based on the model,the design parameters of the seal are studied.Two different conditions of the general case and fixed seal leakage rate are discussed respectively,and the regularities that the seal behaviors are affected by the parameters of the holding screws on the clamp rings and seal faceplates are obtained.The research results can provide a theoretical basis for performance analysis,design and assemblage of the seal.Compared to the numerical methods,the proposed model has the unique advantages of high efficiency,convenience and easy application of constraints. | LIAO ChuanJun HUANG WeiFeng SUO ShuangFu LIU XiangFeng WANG YuMing | 2011 | Science China(Technological Sciences)2011，54，9： | 9 |
| 13 | The input/removal rates of size-fractionated ^210Po in the Jiulongjiang estuary and its implications显示文摘The geochemical behaviors of dissolved (<0.4 mm), low molecular weight (<10 kDa) and colloidal (10 kDa- 0.4 mm) 210Po in surface waters from the Jiulongjiang estuary were examined and the input/removal rates of different 210Po species were estimated. Both dissolved and low molecular weight 210Po were considerably removed during estuarine mixing. However, colloidal 210Po was removed only at low salinity regions (S <15) but had input behavior at high salin-ity surface waters (S >15). The input/removal rates of three species indicate that 210Po was removed rapidly in the Jiu-longjiang estuary. The discrepancy of input/removal rates between 210Po species suggests different geochemical be-havior and a dynamic transformation between 210Po species. Low molecular weight 210Po may be more appropriate for characterizing the 210Po behavior in estuary zone than the traditional dissolved 210Po. | YANG Weifeng, CHEN Min, HUANG Yipu, QIU Yusheng, ZHANG Lei, XING Na & LI Yanping Department of Oceanography, Xiamen University, Xiamen 361005, China Correspondence should be addressed to Huang Yipu (e-mail: yphuang@ jingxina.xmu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，21： | 8 |
| 14 | Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism显示文摘This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources:92individual roots of S.baicalensis from all over China,and secondary metabolites,medicinal materials and inorganic element contents obtained from the testing of 92 S.baicalensis rhizosphere soil samples.The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database.Most of the chemical constituents of S.baicalensis were negatively correlated to latitude and positively correlated to temperature;generally,the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes.By gradual regression analysis,it was found that the content of baicalin in S.baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high(excluding Mg and Ca),which has a negative effect on the accumulation of chemical constituents in S.baicalensis.Based on the cluster analysis of 21 constituents,S.baicalensis from different places of origin was divided into two groups,and S.baicalensis was not genuine only in a specific small region.Within the zone from Chifeng,Inner Mongolia to Taibai,Shaanxi is suitable for accumulation of secondary metabolites of S.baicalensis and such a zone represents a suitable distribution and potential genuine producing area. | GUO LanPing WANG Sheng ZHANG Ji YANG Guang ZHAO ManXi MA WeiFeng ZHANG XiaoBo LI Xuan HAN BangXing CHEN NaiFu HUANG LuQi | 2013 | Science China(Life Sciences)2013，56，11： | 7 |
| 15 | Improvement of Ductility of Powder Metallurgy Titanium Alloys by Addition of Rare Earth Element显示文摘Ti-4.5AI-6.0Mo-1.5Fe, Ti-6AI-1Mo-1Fe 和 Ti-6AI-4V 合金被混合元素的粉末冶金学(下午) 准备微观结构和机械性质上的 Nd 的过程,和效果被扫描电子显微镜学(SEM ) 调查,传播电子显微镜学(TEM ) 和 X 光检查衍射(XRD ) 。因为液相的小数量发生在 sintering 期间, Nd 的增加由 1% 的最大的增长稍微增加了 sintered 钛合金的密度,这被发现。Nd 的增加在张力的力量的改进上显示出小效果,当延伸显著地被改进时。例如,没有 13percent 的 Nd 的增加, Ti-4.5AI-6.0Mo-1.5Fe 的延伸能在 1.2 wt % 的一个 Nd 内容从 1% 被增加。 | Yong LIU Lifang CHEN Weifeng WEI Huiping TANG Bin LIU Baiyun HUANG | 2006 | Journal of Materials Science & Technology2006，22，4： | 7 |
| 16 | Export and remineralization of POM in the Southern Ocean and the South China Sea estimated from ^(210)Po/^(210)Pb disequilibria显示文摘Disequilibria between 210Po and 210Pb in the upper water and their potential applications as a proxy of particle export and remineralization were examined in the Southern Ocean (station IV3) and the South China Sea (NS44). 210Po was deficit in surface waters but excessive relative to 210Pb in subsurface waters. Good positive correlation between 210Po and particulate organic carbon (POC) indicated deficits and excess of 210Po resulted from particulate organic matter (POM) export and remineralization respectively, which was also supported by the decreased δ 13C and increased δ 15N downwards as a result of particle remineralization. On the basis of 210Po/210Pb box-model, POC export flux out of the surface waters were 1.2 mmol C·m-2·d-1 and 2.3 mmol C·m-2·d-1 for station NS44 and IV3, respectively. In the subsurface waters, remineralization fluxes of 210Po were 0.062 Bq·m-2·d-1 and 0.566 Bq·m-2·d-1 for station NS44 and IV3 along with the recycle efficiency of 52±26% and 119±52%, respectively. Remineralized fluxes of POM derived from 210Po and exported POC were 0.6 mmol C·m-2·d-1 and 2.7 mmol C·m-2·d-1 for NS44 and IV3. This study suggested that 210Po was a powerful tracer of particle export and remineralization. | YANG WeiFeng HUANG YiPu CHEN Min QIU YuSheng PENG AnGuo ZHANG Lei | 2009 | Chinese Science Bulletin2009，54，12： | 6 |
| 17 | Disequilibria between ^(210)Po and ^(210)Pb in surface waters of the southern South China Sea and their implications显示文摘Activities of the naturally occurring radionuclides, 210Pb and 210Po, were measured in both dissolved (<0.45 μm) and particulate (>0.45 μm) phases from surface waters of the southern South China Sea. The average activity of particulate 210Pb, 0.23 Bq/m3 (n=23), accounted for about 12% of the total 210Pb, which corresponds with values of open oceans. Particulate 210Po, with an av-erage activity of 0.43 Bq/m3, accounted for about 40% of the total 210Po, which was much higher than those of open and eutrophic oceans. The residence times of total 210Po and 210Pb in surface waters estimated from an irreversible steady-state model were 0.82 a and 1.16 a, respectively. The consis-tently high fractionation factor calculated either by scavenging rate constants (5.42) or Kd values (6.69) suggested that a significant fractionation occurred between 210Po and 210Pb during their removal from solution to particles and that the two radionuclides had different biogeochemical cycling pathways in the oligotrophic South China Sea. Furthermore, our results indicated that there exist different frac-tionation mechanisms between 210Po and 210Pb in different marine environments: in eutrophic ocean, plankton detritus and fecal pellets are the main carrier of 210Po and 210Pb, by which 210Po and 210Pb have been scavenged and removed; while in oligotrophic ocean, microbes could become the main carrier of 210Po and fractionate 210Po and 210Pb significantly as a result of scarce plankton detritus and fecal pellets. These results suggest the use of 210Po to trace marine biogeochemical processes relat-ing to microbial activities and the cycling of sulfur group elements (S, Se, Te and Po). | YANG Weifeng, HUANG Yipu1,2, CHEN Min1,2, ZHANG Lei, LI Hongbin, LIU Guangshan1,2 & QIU Yusheng1,2 1. Department of Oceanography, Xiamen University, Xiamen 361005, China 2. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen 361005, China | 2006 | Science China Earth Sciences2006，49，1： | 6 |
| 18 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 19 | Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model显示文摘Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn. | Yajun Song Yang Li Ya Xiao Wengang Hu Xu Wang Pei Wang Xiaorong Zhang Jiacai Yang Yong Huang Weifeng He Chibing Huang | 2019 | Burns & Trauma2019，7，1： | 5 |
| 20 | Continuous reassortments with local chicken H9N2 virus underlie the human-infecting influenza A (H7N9) virus in the new influenza season, Guangdong, China显示文摘亲爱的编辑, | Wenbao Qi Weifeng Shi Wei Li Lihong Huang Huanan Li Ying Wu Jinghua Yan Peirong Jiao Baoli Zhu Juncai Ma George F. Gao Ming Liao Di Liu | 2014 | Protein & Cell2014，5，11： | 5 |
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