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| 1 | Rice DENSE AND ERECT PANICLE 2 is essential for determining panicle outgrowth and elongation显示文摘包括谷物尺寸和圆锥花序形态学,圆锥花序的建筑学直接决定谷物产量。圆锥花序直立,为在中国的北部分完成理想的植物建筑学被选择,引起了米饭 breeders 的增加的注意。这里,稠密、直立的圆锥花序 2 (dep2 ) 异种,显示出稠密、直立的圆锥花序显型,被识别。没有任何已知的功能的领域, DEP2 编码植物特定的蛋白质。表示介绍 DEP2 表明它高度在年轻纸巾被表示,与在年轻圆锥花序的大多数丰富。词法并且表示分析显示在 DEP2 的那个变化主要影响脊柱和主要、第二等的分支的快速的延伸,但是不损害圆锥花序 primordia 的开始或形成。进一步的分析建议在 dep2 的圆锥花序长度的减少被一个缺点在圆锥花序的指数的延伸期间在房间增长引起。尽管有在 dep2 异种的一种更紧缩的植物类型,在谷物生产的重要改变都没在野类型和 dep2 异种之间被发现。因此, DEP2 的学习不仅加强我们圆锥花序建筑学的分子的基因基础的理解而且为米饭繁殖有重要含意。 | Feng Li Wenbo Liu Jiuyou Tang Jinfeng Chen Hongning Tong Bin Hu Chunlai Li Jun Fang Mingsheng Chen Chengcai Chu | 2010 | Cell Research2010，20，7： | 51 |
| 2 | Hierarchical design of FeCo-based microchains for enhanced microwave absorption in C band显示文摘Microwave absorbing materials(MAMs)has been intensively investigated in order to meet the requirement of electromagnetic radiation control,especially in S and C band.In this work,FeCo-based magnetic MAMs are hydrothermally synthesized via a magnetic-field-induced process.The composition and morphology of the MAMs are capable of being adjusted simultaneously by the atomic ratio of Fe2+to Co2+in the precursor.The hierarchical magnetic microchain,which has a core–shell structure of twodimensional FexCo1−xOOH nanosheets anchored vertically on the surface of a one-dimensional(1D)Co microchain,shows significantly enhanced microwave absorption in C band,resulting in a reflection loss(RL)of lower than−20 dB at frequencies ranging from 4.4 to 8.0 GHz under a suitable matching thickness.The magnetic coupling of Co microcrystals and the double-loss mechanisms out of the core-shell structure are considered to promote the microwave attenuation capability.The hierarchical design of 1D magnetic MAMs provides a feasible strategy to solve the electromagnetic pollution in C band. | Yixuan Han Mukun He Jinwen Hu Panbo Liu Zhongwu Liu Zhonglei Ma Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，1： | 12 |
| 3 | Synthesis of a novel triple-site diphosphinoamine (PNP) ligand and its applications in ethylene tetramerization显示文摘A novel triple-site diphosphinoamine (PNP) ligand was synthesized and characterized. In combination with Cr(III) and methylaluminoxane (MAO), it generated active catalytic systems for ethylene tetramerization toward 1-octene with high catalytic activity and long lifetime. The effects of reaction temperature, molar ratio of Al/Cr and molar ratio of ligand/Cr on catalytic activity and selectivity to 1-octene were studied with reaction kinetics of the catalytic system for ethylene tetramerization described. At the Al/Cr molar ratio of 100, the catalytic activity is up to 2.29×106 g·mol-1 (Cr)·h-1 and the selectivity to 1-octene is 49.65 wt%. | MAO GuoLiang NING YingNan HU WenBo LI ShanMing SONG XianFeng NIU Bo JIANG Tao | 2008 | Chinese Science Bulletin2008，53，22： | 11 |
| 4 | LONG-TERM CREEP ASSESSMENT OF VISCOELASTIC POLYMER BY TIME-TEMPERATURE-STRESS SUPERPOSITION显示文摘Nonlinear viscoelastic creep properties of poly (methyl methacrylate) at various temperatures and stress levels were measured in short-term tests to check the applicability of time-temperature-stress superposition principle, which is the combined form of time-temperature superposition principle and time-stress superposition principle. A unified master creep compliance curve was constructed from the short-term tests by joint application of time-temperature superposition and time-stress superposition. The unified master curve establishes the creep compliance over two years, which is 4.2 decades longer than the test duration. Moreover, it is verified that in nonlinear viscoelastic cases, the time-temperature shift factors are dependent on stresses at which the shifts are applied, while the time-stress shift factors are dependent on temperatures. | Wenbo Luo Chuhong Wang Xiaoling Hu Tingqing Yang | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 8 |
| 5 | Big Learning with Bayesian methods显示文摘The explosive growth in data volume and the availability of cheap computing resources have sparked increasing interest in Big learning, an emerging subfield that studies scalable machine learning algorithms,systems and applications with Big Data. Bayesian methods represent one important class of statistical methods for machine learning, with substantial recent developments on adaptive, flexible and scalable Bayesian learning. This article provides a survey of the recent advances in Big learning with Bayesian methods, termed Big Bayesian Learning, including non-parametric Bayesian methods for adaptively inferring model complexity, regularized Bayesian inference for improving the flexibility via posterior regularization, and scalable algorithms and systems based on stochastic subsampling and distributed computing for dealing with large-scale applications. We also provide various new perspectives on the large-scale Bayesian modeling and inference. | Jun Zhu Jianfei Chen Wenbo Hu Bo Zhang | 2017 | National Science Review2017，4，4： | 8 |
| 6 | Robust attitude coordinated control for spacecraft formation with communication delays显示文摘In this paper,attitude coordinated tracking control algorithms for multiple spacecraft formation are investigated with consideration of parametric uncertainties,external disturbances,communication delays and actuator saturation.Initially,a sliding mode delay-dependent attitude coordinated controller is proposed under bounded external disturbances.However,neither inertia uncertainty nor actuator constraint has been taken into account.Then,a robust saturated delaydependent attitude coordinated control law is further derived,where uncertainties and external disturbances are handled by Chebyshev neural networks(CNN).In addition,command filter technique is introduced to facilitate the backstepping design procedure,through which actuator saturation problem is solved.Thus the spacecraft in the formation are able to track the reference attitude trajectory even in the presence of time-varying communication delays.Rigorous analysis is presented by using Lyapunov-Krasovskii approach to demonstrate the stability of the closed-loop system under both control algorithms.Finally,the numerical examples are carried out to illustrate the efficiency of the theoretical results. | Jian ZHANG Qinglei HU Danwei WANG Wenbo XIE | 2017 | Chinese Journal of Aeronautics2017，30，3： | 7 |
| 7 | Genome Characterization of the First Outbreak of COVID-19 Delta Variant B.1.617.2——Guangzhou City,Guangdong Province,China,May 2021显示文摘On May 20,2021,75-year-old female(Case A)went to a local hospital due to pharyngeal pain and low-grade fever in Liwan District,Guangzhou City,Guangdong Province.The oropharyngeal swab from Case A tested preliminarily positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)/coronavirus disease 2019(COVID-19)virus using a quantitative real-time reverse transcription polymerase chain reaction(RT-qPCR)method after a hospital visit. | Zhencui Li Kai Nie Kuibiao Li Yao Hu Yang Song Min Kang Meng Zhang Xiaoling Deng Jun Yuan Wenbo Xu Baisheng Li | 2021 | China CDC weekly2021，3，27： | 7 |
| 8 | Holocene environmental changes around Xiaohe Cemetery and its effects on human occupation, Xinjiang, China显示文摘Xiaohe 公墓考古学的地点(Cal。4-3.5 ka BP ) 是在 Xinjiang 的最重要的青铜时代地点之一,中国。尽管包围环境现在是极其干旱的沙漠,丰富的考古学的遗体显示人的职业在在 Holocene 的某些时期期间是普通的。当地区性的环境在那里是在整个 Holocene 的干旱沙漠时,地调查和 Xiaohe 公墓附近的沉积侧面的实验室分析显示那是在时期 4.8-3.5 ka BP, 2.6-2.1 ka BP 和 1.2-0.9 的地点附近的湖形成的三个事件 ka BP。似地球形状并且当水开始从 Kongque 河被导出然后推延进 Xiaohe 河盆时,水文学调查表明一个湖或湖在一个低区域形成了。在在 4.8-3.5 ka BP 之间的湖的沉积的活跃化学元素的低数量在湖显示丰富、连续的水体积;活跃化学元素的内容在 2.6-2.1 ka BP 之间增加了,但是仍然在一相对低级,建议水和减少的流入的衰退数量。在 1.2-0.9 ka BP 之间,有活跃元素的一个很高的内容,建议减少的水体积并且显示湖是停滞。相反,气候状况在那里看那的将军在这个区域在 2.9-0.9 ka BP 在 8-6 ka BP,在 6-2.9 ka BP 的一个凉爽潮湿的阶段和一个温暖干燥的阶段有一个温暖潮湿的阶段。在 Xiaohe 公墓附近的水文学进化没与气候变化有一对一的通讯。地区性的比较显示宽广规模的气候的条件通过它对 Tarim 河和 Kongque 河的水体积的影响起了一个重要作用。但是,湖的形成和他们的水平被影响了体积多少水能从 Kongque 被推延到 Xiaohe 河的似地球形状的条件控制河。Xiaohe 公墓和附近的区域的人的职业在青铜时代和 Han-Jin 时期(202 BC-420 广告) 期间对应于二个更早的湖时期,当因为减少的水体积,没有人的活动在第三个湖时期存在时。 | ZHANG Yifei MO Duowen HU Ke BAO Wenbo LI Wenying Idilisi Abuduresule Michael J. STOROZUM Tristram R. KIDDER | 2017 | Journal of Geographical Sciences2017，27，6： | 6 |
| 9 | Non-isothermal crystallization kinetics of Nylon 10T and Nylon 10T/1010 copolymers:Effect of sebacic acid as a third comonomer显示文摘Nylon 10 T and Nylon 10T/1010 samples were synthesized by direct melt polymerization. The non-isothermal crystallization kinetics of Nylon 10 T and Nylon 10T/1010 was investigated by means of differential scanning calorimetry(DSC). Jeziorny equation and Mo equation were applied to describe the non-isothermal crystallization kinetics of the Nylon 10 T and the Nylon 10T/1010. The activation energies for non-isothermal crystallization were obtained by Vyazovkin's method and Friedman's method, respectively. These results showed that Jeziorny equation and Mo equation well described the non-isothermal crystallization kinetics of the Nylon 10 T and the Nylon 10T/1010. It was found that the values of the activation energy for non-isothermal crystallization of the Nylon 10T/1010 were lower than those of the Nylon 10 T at a given temperature or relative crystallinity degree,which revealed that crystallization ability of the Nylon 10T/1010 was higher. The crystal morphology was observed by means of a polarized optical microscope(POM) and X-ray diffraction(XRD). It was found that the addition of sebacic acid comonomer not only did not change the crystal form of the Nylon 10 T, but also significantly increased the number and decreased the size of spherulites. Comparing with the Nylon 10 T, the crystallization rate was increased with the addition of the sebacic acid comonomer. | Zhongqiang Wang Guosheng Hu Jingting Zhang Jiusheng Xu Wenbo Shi | 2017 | Chinese Journal of Chemical Engineering2017，25，7： | 6 |
| 10 | A new strategy to iteratively update scalable universal quantitative models for the testing of azithromycin by near infrared spectroscopy显示文摘The training set of a universal near infrared (NIR) model for quantitative analysis of a drug should cover as many samples of this drug in the market as possible. Inevitably the model may fail for new products that have different excipients and production processes. In such circumstances the model should be updated. We here propose a new strategy to iteratively update a universal NIR quantitative model for azithromycin. We prove that universal quantitative models generated from this new strategy are comparably effective for azithromycin injection powders and azithromycin tablets, compared to the strategy using hierarchical clustering method which we reported previously. Furthermore, we establish the correlation coefficient r between a new sample and the training set samples can be used to decide whether or not the model should be updated. | ZOU WenBo FENG YanChun DONG JiXiong SONG DanQing HU ChangQin | 2013 | Science China Chemistry2013，56，4： | 5 |
| 11 | Strong motion characteristics of the M_w 6.6 Lushan earthquake,Sichuan,China——an insight into the spatial difference of a typical thrust fault earthquake显示文摘Near-field strong ground motions are useful for engineering seismology studies and seismic design, but dense observation networks of damaging earthquakes are still rare. In this study, based on the strong-motion data from the M w 6.6 Lushan earthquake, the ground motion parameters in different spatial regions are systematically analyzed, and the contributions from different effects, like the hanging-wall effect, directivity effect, and attenuation effect are separated to the extent possible. Different engineering parameters from the observed ground motions are compared with the local design response spectra and a new attenuation relation of Western China. General results indicate that the high frequency ground motion, like the peak ground acceleration, on two sides of the fault plane is sensitive to the hanging-wall effect, whereas the low frequency ground motion, like the long period spectral acceleration, in the rupture propagation direction is affected by the directivity effect. Moreover, although the M w 6.6 Lushan earthquake is not a large magnitude event, the spatial difference of ground motion is still obvious; thus, for a thrust faulting earthquake, in addition to the hanging effect, the directivity effect should also be considered. | Hu Jinjun Zhang Wenbo Xie Lili Zhang Qi Jiang Zhijun | 2015 | Earthquake Engineering and Engineering Vibration2015，14，2： | 5 |
| 12 | An Imported Case and an Infected Close Contact of the Omicron Variant of SARS-CoV-2—Guangdong Province,China,December 13,2021显示文摘On November 27,2021,a 67-year-old male returning from Canada via airplane was transferred to the central isolation hotel in Shanghai.During the quarantine,his 1st,4th,7th,and 14th days of specimens returned negative for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19).On December 11,he completed 14 days of centralized isolation and returned to Guangzhou from Shanghai via airplane,then he was closed-loop transferred to Yuexiu District for a 7-day home isolation.On December 12,the local Community Health Service Center routinely collected his throat swab and the result returned to COVID-19 positive on December 13,2021.He was transported to the Guangzhou Eighth People’s Hospital for isolated treatment by negative pressure ambulance on the same day.The patient had two inflamed lungs according to the chest computed tomography(CT)examination,but his most recently updated condition was stable.An estimated 600 close contacts were identified and were placed in centralized isolation.On December 16,one of the close contacts,a 70-year-old female also tested positive for COVID-19.She lived on the lower floor of the same type of apartment as the imported case and spent 19 hours in the same building. | Kuibiao Li Zhonghua Zheng Xiang Zhao Qing Zeng Tengfei Zhou Qianfang Guo Yao Hu Wenbo Xu Zhoubin Zhang Baisheng Li | 2022 | China CDC weekly2022，4，5： | 4 |
| 13 | Synthesis of taurine-fluorescein conjugate and evaluation of its retina-targeted efficiency in vitro显示文摘In this work, retinal penetration of fluorescein was achieved in vitro by covalent attachment of taurine to fluorescein, yielding the F-Tau conjugate. Nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) were used to confirm the successful synthesis of F-Tau. The cellular uptake of F-Tau in adult retinal pigment epithelial cells (ARPE-19) and human retinal microvascular endothelial cells (hRMECs) was visualized via confocal scanning microscopy. The results indicated an improvement of solubility and a reduction of logP of F-Tau compared with fluorescein. As compared with fluorescein, F-Tau showed little toxicity, and was retained longer by cells in uptake experiments. F-Tau also displayed higher transepithelial permeabilities than fluorescein in ARPE-19 and hRMECs monolayer cells (Po0.05). These results showed that taurine may be a useful ligand for targeting small-molecule hydrophobic pharmaceuticals into the retina. | Meihong Huang Jiaqi Song Bingzheng Lu Huizhi Huang Yizhen Chen Wei Yin Wenbo Zhu Xinwen Su Chuanbin Wu Haiyan Hu | 2014 | Acta Pharmaceutica Sinica B2014，4，6： | 4 |
| 14 | Ionospheric disturbances associated with the 2015 M7.8 Nepal earthquake显示文摘Based on the total electron content(TEC) derived from Global Positioning System(GPS) observations of the Crustal Movement Observation Network of China(CMONOC) and the Global Ionosphere Map(GIM)from the Center for Orbit Determination in Europe(CODE),we detected and analyzed the ionospheric variations during the 2015 M7.8 Nepal earthquake(including the pre-earthquake ionospheric anomalies and coseismic ionospheric disturbances(CIDs) following the main shock).The analysis of vertical total electron content(VTEC) time series shows that the large-scale ionospheric anomalies appeared near the epicenter two days prior to the earthquake.Moreover,the pre-earthquake ionospheric anomalies were also observed in the geomagnetically conjugated region.In view of solar-terrestrial environment,the pre-earthquake ionospheric anomalies could be associated with the Nepal earthquake.In addition,we also detected the CIDs through the high-frequency GPS observation stations.The CIDs had obvious oscillated waveforms with the peak-to-peak disturbance amplitudes of about 1 TECu and 0.4 TECu,which propagated approximately with the horizontal velocities of 877 ± 75 m/s and 319 ± 30 m/s,respectively.The former is triggered directly by the acoustic waves which originated from the energy release of the earthquake near the epicenter,while the latter could be stimulated by the acoustic-gravity waves from the partial transformation of the acoustic waves. | Yiyan Zhou Jian Yang Fuying Zhu Fanfan Su Liangchen Hu Wenbo Zhai | 2017 | Geodesy and Geodynamics2017，8，4： | 4 |
| 15 | Star-shaped conjugated oligoelectrolyte for bioimaging in living cells显示文摘A new star-shaped oligoelectrolyte (TEFCOONa) with triphenylamine as the core, acetylene as linkage and anionic fluorenes as arms was obtained and used for direct imaging in living PANC-1 cells. Because of the hydrophobic conjugated groups of the oli-goelectrolyte, TEFCOONa can form nanospheres with an average diameter of^75 nm in 10 mmol/L PBS. These nanospheres possess a relatively high absolute quantum yield (16.5% in PBS), low cytotoxicity and can penetrate into the nucleus through the cytoplasm, which is essential for living cellular imaging. Collectively, these results validate our rational design of conjugated oligoelectrolyte and even hyper branched polymers-copolyelectrolyte as effective nanovectors for bioimaging and other clinical applications. | SONG WenLi JIANG RongCui YUAN Yan LU XiaoMei HU WenBo FAN QuLi HUANG Wei | 2013 | Chinese Science Bulletin2013，58，21： | 4 |
| 16 | Dam foundation excavation techniques in China:A review显示文摘A protective layer(PL) is commonly reserved above foundation surface to protect the underlying rock mass during dam foundation excavation. In China, the PL of dam foundation is conventionally subdivided into two or three thin layers and excavated with the shallow-hole blasting method, even by pneumatic pick method in case of soft rock mass. The aforementioned layered excavation of the PL delays the construction of the whole project. After nearly 30-year practices, several safe and effcient methods for the PL excavation of dam foundation are gradually developed. They include shallow-hole bench blasting with cushion material(SBC) at the bottom of the hole, and horizontal smooth blasting(HSB). The PL is even cancelled on the condition that horizontal pre-split technique is employed during dam foundation excavation. This paper introduces the aforementioned two PL excavation methods(shallow-hole blasting and bench blasting) and horizontal pre-split technique of dam foundation without protective layer(HPP). The basic principles of blasting method, blasting geometry, charge structure, drill-and-blast parameters of typical projects are examined. Meanwhile, the merits and limitations of each method are compared. Engineering practices in China show that HSB is basically the optimal method for dam foundation PL excavation in terms of foundation damage control and rapid construction. Some new problems for dam foundation PL excavation arising, such as strong unloading and relaxation phenomenon that encountered in the gorge region of southwest China, are needed to be addressed; and the corresponding countermeasures are discussed as well. | Yuzhu Zhang Wenbo Lu Ming Chen Peng Yan Yingguo Hu | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，6： | 3 |
| 17 | Mechanical properties and frictional resistance of Al composites reinforced with Ti3C2Tx MXene显示文摘Two-dimensional(2D)Ti3C2Tx MXene is an attractive additive not only used in base oil due to its low friction coefficient,but also used in composites due to its high aspect ratio and rich surface functional groups.So far there has been intense research into polymer matrix composites reinforced with Ti3C2Tx,Here we report on the use of 2D Ti3C2Tx to enhance the mechanical and frictional properties of Al matrix composites.Ti3C2Tx/Al composites were designed and prepared by pre s sureless sintering followed by hot extrusion technique.The prepared composites exhibit a homogeneous distribution of Ti3C2Tx.The Vickers hardness and the tensile strength continuously increase with increasing Ti3C2Tx content.A hardness of 0.52 GPa and a tensile strength of 148 MPa were achieved in the 3 wt%Ti3C2Tx/Al composite.The frictional properties of pure Al and the Ti3C2Tx/Al composite were comparably studied under dry sliding.A low friction coefficient of 0.2,twice lower than that of pure Al,was achieved in the 3 wt%Ti3C2Tx/Al composite.Ti3C2Tx acting as a solid lubricant reduces the abrasive wear in the composite,improving the frictional properties of Al matrix composites. | Jie Hu Shibo Li Jing Zhang Qiuying Chang Wenbo Yu Yang Zhou | 2020 | Chinese Chemical Letters2020，31，4： | 3 |
| 18 | Microhabitat Segregation of Parapatric Frogs in the Qinling Mountains显示文摘Coexistence mechanisms for species with similar ecological traits and overlapping geographic distributions are basic questions in ecology and evolutionary biology. Specific habitat requirements often limit distribution range as well as facilitate partitioning resource utilization in ecological similar species. Understanding niche segregation and differences in microhabitat utilization can contribute to identifying coexistence mechanisms between parapatric species. Feirana quadranus and F. taihangnica are two closely related frog species with parapatric geographic ranges and an elongated contact zone within the Qinling Mountains, which is an important watershed for East Asia. Here, we analysed the difference in microhabitat utilization between the two frog species and explored the key ecological factors that induced their microhabitat differentiation based on quadrats sampled in the contact zone. Our comparison of twenty environmental variables showed that both species used microhabitats with alkalescent warm water and gentle slope conditions. The principal component analysis indicated that climate-related variables, vegetation conditions, and river width were the important factors for microhabitat utilization of these species. These findings contribute to our understanding on the coexistence mechanisms of these two related and parapatric Asian mountain frog species. This study can also be helpful for identifying target habitats to conduct conservation actions and management strategies effectively in the face of environmental changes. | Shengnan YANG Jianping JIANG Zhenhua LUO Xin YANG Xiaoyi WANG Wenbo LIAO Junhua HU | 2019 | Asian Herpetological Research2019，10，1： | 2 |
| 19 | Visualizing Photodynamic Therapy in Transgenic Zebrafish Using Organic Nanoparticles with Aggregation-Induced Emission显示文摘Photodynamic therapy(PDT) employs accumulation of photosensitizers(PSs) in malignant tumor tissue followed by the light-induced generation of cytotoxic reactive oxygen species to kill the tumor cells. The success of PDT depends on optimal PS dosage that is matched with the ideal power of light. This in turn depends on PS accumulation in target tissue and light administration time and period.As theranostic nanomedicine is driven by multifunctional therapeutics that aim to achieve targeted tissue delivery and image-guided therapy, fluorescent PS nanoparticle(NP)accumulation in target tissues can be ascertained through fluorescence imaging to optimize the light dose and administration parameters. In this regard, zebrafish larvae provide a unique transparent in vivo platform to monitor fluorescent PS bio-distribution and their therapeutic efficiency. Using fluorescent PS NPs with unique aggregation-induced emission characteristics, we demonstrate for the first time the real-time visualization of polymeric NP accumulation in tumor tissue and, more importantly, the best time to conduct PDT using transgenic zebrafish larvae with inducible liver hyperplasia as an example. | Purnima Naresh Manghnani Wenbo Wu Shidang Xu Fang Hu Cathleen Teh Bin Liu | 2018 | Nano-Micro Letters2018，10，4： | 2 |
| 20 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
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