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您的检索式：作者名="HOUKAI CHEN"
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| 1 | Wide-field in situ multiplexed Raman imaging with superresolution显示文摘Because of the fingerprint-like specificity of its characteristic spectrogram, Raman spectral imaging has been applied widely in various research areas. Using a combination of structured illumination with the surface-enhanced Raman scattering(SERS) technique, wide-field Raman imaging is developed with a significant improvement in spatial resolution. As a result of the relatively narrow Raman characteristic peaks, optically encoded SERS nanoparticles can be used to perform multiplexed imaging. The results show excellent superresolution wide-field multiplexed imaging performance. The developed technique has extraordinary potential for applications in biological imaging and other related fields. | HOUKAI CHEN XIAOJING WU YUQUAN ZHANG YONG YANG CHANGJUN MIN SIWEI ZHU XIAOCONG YUAN QIAOLIANG BAO JING BU | 2018 | Photonics Research2018，6，6： | 2 |
| 2 | Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid显示文摘Liver injury caused by acetaminophen(AP)overdose is a leading public health problem.Although APinduced liver injury is well recognized as the formation of N-acetyl-p-benzoquinone(NAPQI),a toxic metabolite of AP,resulting in cell damage,emerging evidence indicates that AP-induced liver injury is also associated with gut microbiota.However,the gut microbiota-involved mechanism remains largely unknown.In our study,we found that vancomycin(Vac)pretreatment(100 mg/kg,twice a day for 4 days)attenuated AP-induced liver injury,altered the composition of gut microbiota,and changed serum metabolic profile.Moreover,we identified Vac pretreatment elevated cecum and serum 2-hydroxybutyric acid(2-HB),which ameliorated AP-induced cell damage and liver injury in mice by reducing AP bioavailability and elevating GSH levels.Our current results revealed the novel role of 2-HB in protecting AP-induced liver injury and add new evidence for gut microbiota in affecting AP toxicity. | Ningning Zheng Yu Gu Ying Hong Lili Sheng Linlin Chen Feng Zhang Jie Hou Weidong Zhang Zean Zhang Wei Jia Houkai Li | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 1 |
| 3 | Facilitated tip-enhanced Raman scattering by focused gap-plasmon hybridization显示文摘Tip-enhanced Raman scattering(TERS)spectroscopy is a nondestructive and label-free molecular detection approach that provides high sensitivity and nanoscale spatial resolution.Therefore,it has been used in a wide array of applications.We demonstrate a gap-plasmon hybridization facilitated by a bottom-illuminated TERS configuration.The gap-plasmon hybridization effect is first performed with the finite-difference time-domain method to optimize the parameters,and experiments are then conducted to calibrate the performance.The results demonstrate an enhancement factor of 1157 and a spatial resolution of 13.5 nm.The proposed configuration shows great potential in related surface imaging applications in various fields of research. | HOUKAI CHEN YUQUAN ZHANG YANMENG DAI CHANGJUN MIN SIWEI ZHU XIAOCONG YUAN | 2020 | Photonics Research2020，8，2： | 1 |
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