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| 1 | Evolving management of colorectal cancer显示文摘This article reviews recent advances in surgical techniques and adjuvant therapies for colorectal cancer, including total mesorectal excision, the resection of liver and lung metastasis and advances in chemoradiation and foreshadows some interventions that may lie just beyond the frontier. In particular, little is known about the intracellular and extracellular cascades that may influence colorectal cancer cell adhesion and metastasis. Although the phosphorylation of focal adhesion kinases and focal adhesion associated proteins in response to integrin-mediated cell matrix binding ('outside in integrin signaling') is well described, the stimulation of cell adhesion by intracellular signals activated by pressure prior to adhesion represents a different signal paradigm. However, several studies have suggested that increased pressure and shear stress activate cancer cell adhesion. Further studies of the pathways that regulate integrin-driven cancer cell adhesion may identify ways to disrupt these signals or block integrin-mediated adhesion so that adhesion and eventual metastasis can be prevented in the future. | Jochem van der Voort van Zijp Harald J Hoekstra Marc D Basson | 2008 | World Journal of Gastroenterology2008，14，25： | 16 |
| 2 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 3 | Effect of light therapy on biopterin, neopterin and tryptophan in pa'- tients with seasonal affective disorder显示文摘 | Hoekstra R Fekkes D van de Wetering BJ | 2003 | Psychiatr Res2003，120，1： | 1 |
| 4 | Cationiclipids, lipoplexes and intracellular delivery of genes 显示文摘 | Wasungu L Hoekstra D | 2006 | Control Realease2006，116，2： | 1 |
| 5 | The subapical compartment:a novel sorting centre显示文摘 | van IJzendoorn SC Hoekstra D | | 0，，04： | 1 |
| 6 | Management of giant liv- er hemangiomas: an update 显示文摘 | Hoekstra LT Bieze M Erdogan D | 2013 | Expert Rev Gastroenterol Hepa- to12013，7，3： | 1 |
| 7 | Patterns and correlates of acute (24 hours) use of beta-blockers for non-ST-segment elevation acute coronary syndromes: Results from the CRUSADE initiative显示文摘 | MILLER C D MULGUND J HOEKSTRA J W | 2005 | Ann Emergen Med2005，46，： | 1 |
| 8 | Effect of light therapy on biopterin,neopterin and tryptophan in patients with seasonal affective disorder显示文摘 | Hoekstra R Fekkes D van de Wetering BJ | 2003 | Psychiatry Res2003，12，2： | 1 |
| 9 | Control of microporosity of Al2O3 pillared Clays:effect of pH,calcination temperature and Clay cation exchange capacity显示文摘 | N D Hutson M J Hoekstra R T Yang | 1999 | Microporous and Mesoporous Materials1999，28，3： | 1 |
| 10 | Going against the flow: A critical analysis of inter - state virtual water trade in the context of India's National River Linking Program 显示文摘 | VERMA S KAMPMAN D A ZAAG P HOEKSTRA A Y | 2009 | Physics and Chemistry of the Earth2009，34，45： | 1 |
| 11 | Management of giant liver hemangiomas: an update显示文摘 | Hoekstra LT Bieze M Erdogan D | 2013 | Expert Rev Gastroenterology Hepatol2013，7，3： | 1 |
| 12 | Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat显示文摘 | Hafeman D G Sunde R A Hoekstra W G | 1974 | The Journal of Nutrition1974，104，5： | 1 |
| 13 | Gene delivery by cationic lipid vectors : overeoming cellular barriers显示文摘 | Zuhorn I S Engberts J B Hoekstra D | 2007 | Eur Biophys J2007，36，45： | 1 |
| 14 | Is 18F23' 2flu2oro23' 2deoxy2L2thymidine useful for the staging and restaging of non2small cell lung cancer显示文摘 | Cobber D C Elsinga P H Hoekstra H J | 2004 | J NuclMed2004，45，10： | 1 |
| 15 | Chemical development of CI-1008, an enantiomerically pure anticonvulsant 显示文摘 | Hoekstra M S Sobieray D M Schwindt | 1997 | Organic Process Research & Development1997，1，1： | 1 |
| 16 | Control of microporosity of Al2O3 - pillared clays : Effect of pH,calcination temperature and clay cation exchange capacity显示文摘 | Hutson N D Hoekstra M J Yang R T | 1999 | Microporous and Mesoporous Materials1999，28，3： | 1 |
| 17 | Gene-delivery by cationic lipid vectors:overcoming cellular barriers显示文摘 | ZUHORN I S ENGBERTS J B HOEKSTRA D | 2007 | European Biophysics Journal2007，36，4： | 1 |
| 18 | Association of lysozyme to phospholipid surfacesand vesicle fusion显示文摘 | Arnold K Hoekstra D Ohki S | 1992 | Biochim Bio- phys Acta1992，1124，： | 1 |
| 19 | A measurement of weak lensing by large-scale structure in red-sequence cluster survey fields显示文摘 | Hoekstra H Yee H K C Gladders M D | 2002 | ApJ2002，572，： | 1 |
| 20 | Chemical development of CI - 1008, an enantiomerically pure anticonvulsant显示文摘 | HOEKSTRA M S SOBIERY D M SCHWINDT M A | 1997 | Org Proc Res Dev1997，1，： | 1 |
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