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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Defoliation effects on en- zyme activities of the cctomycorrhizal fungus Suillus granulates in a Pinus contorta ( lodgepole pine) stand in Yellowstone Na- tional Park 显示文摘 | Cullings K Ishkhanova G Henson J | 2008 | Occologia2008，158，： | 1 |
| 3 | Macular pigment and risk for age-related macular degeneration in subjects form a Northern European population 显示文摘 | Beatty S Murray I J Henson DB Carden D Koh H Boulton ME | 2001 | Invest Ophthalmol Vis Sci2001，42，2： | 1 |
| 4 | The small footprint waste-water treatment process显示文摘 | STEP HENSON T MAN A UPTON J | 1993 | Chemistry & Industry1993，19，： | 1 |
| 5 | Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma显示文摘 | KRAFT M CASSELL G H HENSON J E | 1998 | Am J Respir Crit Care Med1998，158，3： | 1 |
| 6 | Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure显示文摘 | Mancini DM Henson D La Manca J | 1995 | Circulation1995，91，2： | 1 |
| 7 | Selection of model parameters for off-line parameter estimation显示文摘 | Li R Henson M A Kurtz M J | 2004 | 1EEE Trans on Control Systems Technology2004，12，3： | 1 |
| 8 | Alzheimer's patients engage an alternative network during a memory task显示文摘 | PARIENTE J COLE S HENSON R | 2005 | Ann Neurol2005，58，6： | 1 |
| 9 | Evaluation of Heated Solutions of Sulfur Dioxide, Ethanol, and Hydrogen Peroxide to Control Postharvest Green Mold of Lemons 显示文摘 | SMILANICK J L MARGOSAN D A HENSON D J | 1995 | Plant Dis1995，，79： | 1 |
| 10 | Feedback linearizing control of discrete-time nonlinear systems with input constraints 显示文摘 | KURTZ M J HENSON M A | 1998 | Interna- tional Journal of Control1998，70，4： | 1 |
| 11 | Pathogenic properties of fungal melanins显示文摘 | Butler M J Day A W Henson J M | 2001 | Mycologia2001，93，： | 1 |
| 12 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 13 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy显示文摘 | Henson B J Bhattacharjee S O'Dee DM | 2009 | Genes Chromosomes Cancer2009，48，7： | 1 |
| 14 | Core or juvenile wood of lOblolly and slash pine trees显示文摘 | Zobel B J Webb C Henson F | 1959 | TAPPI1959，42，5： | 1 |
| 15 | Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malig- nancy显示文摘 | Henson B J Bhattacharjee S O'Dee DM | 2009 | Genes Chromosomes Cancer2009，48，7： | 1 |
| 16 | Reversible acceleration of the corrosion of AISI304 stainless steel exposed to seawater induced by growth and secretions of the marine bacterium vibrio natriegens 显示文摘 | Nivens D E Nichols P D Henson J M | 1986 | Corrosion1986，42，4： | 1 |
| 17 | Costs and benefits of implementing HACCP in the UK dairy processing sector 显示文摘 | Henson S Holt G Northern J | 1999 | Conference on Economics of HACCP June1999，，5： | 1 |
| 18 | Hierarchical load hindcasting using reanalysis weather显示文摘 | Black J D Henson W L W | 2014 | IEEE Transactions on Smart Grid2014，5，1： | 1 |
| 19 | Mitochondria are a direct site of A beta accumulation in Alzheimer′s disease neurons:implications for free radical generation and oxidative damage in disease progression显示文摘 | Manczak M Anekonda TS Henson E Park BS Quinn J Reddy PH | 2006 | Hum Mol Genet2006，15，9： | 1 |
| 20 | Scopolamine but not lorazepam modulates face repetition priming: A psychopharmacological fMR1 study显示文摘 | Thiel C M Henson R N A Dolan R J | 2002 | Neuropsychopharmacology2002，27，2： | 1 |
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