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		题名	作者	年代	出处	被引量
	1	Chitosan and β-cyclodextrin Microspheres as Pulmonary Sustained Delivery Systems显示文摘Chitosan andβ-cyclodextrin were used to prepare microspheres with theophylline for pulmonary delivery by spray drying method.The characteristics,mucociliotoxicity,permeation rate and drug release were studied.The drug entrapments of microspheresⅠ,ⅡandⅢ were from 35.70%to 21.09% and 13.33%,while yields and encapsulation efficiencies were higher than 45% and about 90% respectively. The microspheres possessed low tap densities(0.34-0.48 g/cm3),appropriate diameters(3.35-3.94μm)and theoretical aerodynamics diameters(2.20-3.04μm).SEM images showed the microspheres were spherical with smooth or wrinkled surface surfaces.FT-IR demonstrated theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin.The microspheres could effectively reduce the ciliotoxicity and easy to penetrate the memberine.The in vitro release of the microspheres was related to the ratio of drug/polymer and microspheresⅡ had a prolong release,providing the release of 72.00%in 12 h.The results suggestes that chitosan/β-cyclodextrin microspheresⅡare a promising carrier as sustained release for pulmonary delivery.	ZHANG Weifen CHEN Xiguang LI Piwu HE Qiangzhi ZHOU Huiyun CHA Dongsu	2008	Journal of Wuhan University of Technology(Materials Science)2008，23，4：	2

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