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| 1 | 世界卫生组织(WHO)造血与淋巴组织肿瘤分类方案:临床顾问委员会会议报告显示文摘引言 :从 1995年开始 ,欧洲病理学工作者协会和血液病理学会一直致力于制定一个新的世界卫生组织 (WHO)血液恶性肿瘤分类方案 ,该分类方案包括淋巴系肿瘤、髓系肿瘤、组织细胞肿瘤和肥大细胞肿瘤。 材料与方法 :此项 WHO计划共组成十个病理学工作者委员会 ,负责确定病种和作出定义。另外还成立一个由国际血液学家和肿瘤学家组成的临床顾问委员会 (CAC)以保证该分类的临床实用性。 1997年 11月召开会议讨论了与该分类有关的临床问题。 结果 :WHO采纳了 1994年国际淋巴瘤研究组 (IL SG)报告的修订欧美淋巴系肿瘤分类 (REAL)方案作为淋巴系肿瘤的分类方案。该方案的分类方法遵循以下原则 :分类应是联合应用形态学、免疫表型、遗传特征及临床特征能够清楚界定的“真实存在”(“real”)病种的名录 ,上述各项特征的相对重要性因病种不同而异 ,不存在任何“金标准”。 WHO将 REAL分类原则延用于髓系肿瘤和组织细胞肿瘤 ,髓系肿瘤的分类包括联合应用细胞形态学和细胞遗传学异常能够界定的各个病种。围绕一系列临床问题召集的这次 CAC会议 ,就提交的大多数问题达成共识 ,这些问题及共识将详述于下。对于另外一些问题 ,CAC认为淋巴系肿瘤临床分组既无必要也不必需 ,患者的治疗取决于淋巴瘤的具体类型 ,如有? | N L Harris E S Jaffe J Diebold G Flandrin H K Muller-Hermelink J Vardiman T A Lister C D Bloomfield 张凤奎 郝玉书 | 2001 | 白血病.淋巴瘤2001，10，3： | 20 |
| 2 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 3 | Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention显示文摘 | Debasis Bagchi Manashi Bagchi Sidney J Stohs Dipak K Das Sidhartha D Ray Charles A Kuszynski Shantaram S Joshi Harry G Pruess | 2000 | Toxicology2000，，2： | 3 |
| 4 | Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis显示文摘 | Guy D Eslick Lynette L.-Y Lim Julie E Byles Harry H-X Xia Nicholas J Talley | 1999 | The American Journal of Gastroenterology1999，，： | 2 |
| 5 | Mechanism of mechanical failure of sapphire at high temperature 显示文摘 | Harris D C Sehmid Frederick Mecholsky J J | 1994 | Proc SPIE1994，2286，： | 1 |
| 6 | Computational fluid dynamics for chemical reactor engineering显示文摘 | Harris C K Roekaerts D Rosendal F J J | 1996 | Chem Eng Sci1996，51，10： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Odour intensities of hop oil components 显示文摘 | Guadagni D G Buttery R G Harris J | 1966 | Journal of the Science of Food and Agriculture1966，17，3： | 1 |
| 9 | A survey of estrogenic activity in UK inland waters 显示文摘 | Harries J Sheahan D Osborne J A | 1997 | Environ Toxicol Chem1997，16，： | 1 |
| 10 | The World Health Organization (WHO) classification of the myeloid neoplasms显示文摘 | Vardiman J W Harris N L Brunning R D | 2002 | Blood2002，100，7： | 1 |
| 11 | 显示文摘 | Harris L A Goff J D Carmichael A Y | 2003 | Chem Mater2003，15，： | 1 |
| 12 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 13 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 14 | The effect of processing variables on the morphology of electrospun nanofibers and textiles 显示文摘 | Deilzel J M Kleinmeyer J Harris D | 2001 | Polymer2001，42，： | 1 |
| 15 | The World Health Organization (WHO) classification of the myeloid neoplasms 显示文摘 | Vardiman J W Harris N L Brunning R D | 2002 | Blood2002，100，7： | 1 |
| 16 | Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis显示文摘 | Clegg DO Reda D J Harris CL | 2006 | N Engl J Med2006，354，8： | 1 |
| 17 | Antibiotic-loaded chitosan film for infection prevention:A preliminary in vitro characterization显示文摘 | J Keaton Smith Joel D Bumgardner Harry 5 Courtney | 2010 | Biomedical Materials2010，94，1： | 1 |
| 18 | Prediction of the stability of the Mn+1 AX, phases from first principles 显示文摘 | Keast V J Harris S Smith D K | 2009 | Phys Rev B2009，80，21： | 1 |
| 19 | Survey of estrogenic activity in United Kingdom inland waters 显示文摘 | HARRIES J E SHEAHAN D JOBLING S | 1996 | Environmental Toxicology and Chemistry1996，15，11： | 1 |
| 20 | Trade liberalisation and establishment exit in New Zealand manufacturing显示文摘 | GIBSON J K HARRIS R D | 1996 | The Review of Economic and Statistics1996，78，3： | 1 |
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