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| 1 | Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products显示文摘Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products(DBPs), many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP(s) drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order: acetamides > acetic acids > acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays. | David Hanigan Lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff | 2017 | Journal of Environmental Sciences2017，29，8： | 5 |
| 2 | Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice显示文摘 | Townsend DM Hanigan MH | 2002 | J Pharmacol Exp Ther2002，300，： | 2 |
| 3 | Cerebral salt wasting syndnme: a review 显示文摘 | Hanigan MR | 1996 | Neurosrgery1996，38，1： | 2 |
| 4 | Review:Ammonia emissions from dairy farms and beef feedlots显示文摘 | Hristov A N Hanigan M Cole A | 2011 | Canadian Journal of Animal Science2011，，91： | 1 |
| 5 | Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production 显示文摘 | BEQUETI'E B J HANIGAN M D CALDER A G | 2000 | J Dairy Sci2000，83，4： | 1 |
| 6 | A model of net amino acid absorption and utilization by the portal-drained viscera of the lactating dairy cow 显示文摘 | Hanigan M D | 2004 | J Dairy Sci2004，87，： | 1 |
| 7 | An evaluation of postabsorptive protein and amino acid metabolism in the lactating dairy cow显示文摘 | Hanigan M D J P Cant | 1998 | J Dairy Sci1998，81，： | 1 |
| 8 | Suicide and drought in New South Wales, Australia, 1970 - 2007 显示文摘 | Hanigan IC Butler CD Kokic PN | 2012 | P Nalt Acad Sci USA2012，109，13： | 1 |
| 9 | Role for DNA methylation in the control of cell typespecific maspin expression显示文摘 | Futscher BW Oshiro MM Wozniak RJ Holtan N Hanigan CL Duan H | 2002 | Nat Genet2002，31，2： | 1 |
| 10 | Respiratory hospital admissions were associated with ambient airborne pollen in Darwin, Australia, 2004- 2005显示文摘 | Hanigan IC Johnston FH | 2007 | Clin Exp Allergy2007，37，： | 1 |
| 11 | Formation, precursors, control, and occurrence of nitrosamines in drinking water: A review显示文摘 | Stuart W. Krasner William A. Mitch Daniel L. McCurry David Hanigan Paul Westerhoff | 2013 | Water Research2013，，13： | 1 |
| 12 | Extracellular glutathione is a source of cysteine for cells that express γ-glutamyl transpeptidase 显示文摘 | Ricketts W A | 1993 | Biochemistry1993，32，24： | 1 |
| 13 | Cisplatin nephrotoxicity: inhibition of gamma-glutamyl transpeptidase blocks the nephrotoxicity of cisplatin without reducing pla- tinum concentrations in the kidney显示文摘 | Hanigan MH Gallagher BC Taylor PT Jr | 1996 | Am J Obstet Gynecol1996，175，2： | 1 |
| 14 | Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity显示文摘 | Hanigan MH Gallagher BC Taylor PT Jr Large MK | 1994 | Cancer Res1994，54，22： | 1 |
| 15 | Odontoid fractures in elderly patients显示文摘 | Hanigan WC Powell FC Elwood PW | 1993 | J Neurosurg1993，78，1： | 1 |
| 16 | Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase显示文摘 | Hanigan MH Ricketts WA | 1993 | Biochemistry1993，32，24： | 1 |
| 17 | Gamma-glutamyl transpeptidase-its role in hepatocarcinogenesis显示文摘 | Hanigan MH Pitot HC | 1985 | Carcinogenesis1985，6，2： | 1 |
| 18 | Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production 显示文摘 | BEQUETTE B J HANIGAN M D CALDER A G | 2000 | Journal of Dairy Science2000，83，4： | 1 |
| 19 | 视频游戏“热身活动”对腹腔镜手术操作技能的影响(英文)显示文摘目的腹腔镜技术需要经过专门培训,也已证实确实存在手术失误。已经有研究证明在手术之前先进行'热身活动'可以提高腹腔镜操作技能。本研究主要探讨外科医生在进行腹腔镜部分操作和临床操作之前是否能从选择性视频游戏的'热身运动'中获益。方法本研究包括303名外科医生(男249名,女54名)。受试者分成对照组(n=180)和实验组(n=123)。实验组在操作之前先进行3段6分钟已验证的视频游戏。在热身之后立即进行眼镜蛇绳部分操作和缝合练习。结果在所有10个试验中,眼镜蛇绳训练之前进行视频游戏热身的外科医生明显比一开始就直接进行眼镜蛇绳训练的医生速度更快。实验组和对照组的总缝合分数有显著差异(t=2.28,df=288,P<0.05)。精英训练总分数显示,实验组进行腹腔镜操作表现更好。结论本研究表明,在进行腹腔镜操作和临床操作(体内缝合)之前,进行选择性视频游戏'热身'的受试者要比那些没有进行热身的受试者速度快,错误率低。然而,确定这是否能作为一种好的方法应用于临床实践还需要更进一步的研究。 | 皇甫玉爽 应小燕 James C.Rosser Jr. Douglas A.Gentile Kevin Hanigan Omar K.Danner | 2013 | 中国微创外科杂志2013，13，4： | 1 |
| 20 | Cisplatin nephrotoxicity:molecular mechanisms显示文摘 | HANIGAN M H DEVARAIAN P | | 0，，： | 1 |
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