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| 1 | Skeletal myoblast based delivery of angiogenic growth factors:a comparison between angiopoietin-1 and VEGF gene delivery for therapeutic angiogenesis in the heart显示文摘Objectives This study investigated the efficacy of human skeletal myoblasts (SkM) mediated either human vascular endothelial growth factor-165 (hVEGF165) or angiopoietin-1 (Ang-1) on vascular development and myocardial regional perfusion. Methods A porcine heart model of chronic infarction was created in 28 female swine by coronary artery ligation. The animals were randomized into: (1) group-1, DMEM injected (n=6), (2) group-2, Ad-null transduced SkM transplanted (n=6), (3) group-3, Ad-hVEGF165 transduced SkM transplanted (n=8), and (4) group-4, Ad-Ang-1 transduced SkM (n=8). Three weeks later, 5 ml DMEM containing 3×108 SkM carrying exogenous genes were intramyocardially injected into 20 sites in left ventricle in groups-2, -3 and -4. Animals in group-1 were injected 5 ml DMEM without cells. Animals were kept on 5 mg/kg cyclosporine per day for 6 weeks. Regional blood flow was measured using fluorescent microspheres. The heart was explanted at 2, 6 and 12 weeks after transplantation for histological studies. Results Histological examination showed survival of lac-z expressing myoblasts in host tissue. Capillary density based on Von Willebrand factor-VIII (vWF-VIII) at low power field (×100) was 57.13±11.85 in group-3 at 6 weeks and declined to 32.1±5.21 at 12 weeks, while it was 39.9±10.26 at 6 weeks and increased to 45.14±6.54 at 12 weeks in group-4. The mature blood vessel index was highest in group- 4 at 6 and 12 weeks after transplantation. The regional blood flow in the center and peri-infarct area was significantly increased in animals of groups-3 and -4. Conclusions SkM carrying either hVEGF165 or Ang-1 induced neovascularization with increased blood flow. Ang-1 overexpression resulted in mature and stable blood vessel formation and may be a more potent arteriogenic inducer for neovascularization. | Husnain Kh Haider In-Chin Song Peter K Law Eugene KW Sim | 2006 | Journal of Geriatric Cardiology2006，3，3： | 3 |
| 2 | Prevalence and distribution of peste des petits ruminants virus infection in small ruminants 显示文摘 | Haider A K Muhammad S Muhammad A | 2008 | Small Ruminant Res2008，79，： | 1 |
| 3 | Phytotron studies to compare nitrogen losses from com-planted soil by the 15N balance or direct dinitrogen and nitrous oxide measurements 显示文摘 | Heinemeyer O Haider K Mosier A | 1988 | Biol Fertil Soils1988，6，1： | 1 |
| 4 | Nonviral vector-based gene transfection of primary human skeletal myoblasts显示文摘 | Ye L Haider H Kh Esa W B Law P K Zhang W Su L | 2007 | Exp Biol Med ( Maywood)2007，232，： | 1 |
| 5 | Enterocins in food preservation显示文摘 | HAIDER K STEVE F PAK L Y | 2010 | International Journal of Food Microbiology2010，141，12： | 1 |
| 6 | Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells 显示文摘 | Haider HKh Ahmed RP | 2011 | Rejuvenation Res2011，14，4： | 1 |
| 7 | Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin- induced acute kidney injury 显示文摘 | Salahudeen A K Haider N Jenkins J | 2008 | Am J Physiol Renal Physiol2008，294，6： | 1 |
| 8 | Treatment of advanced breast cancer with gemcitabine and vinorelbine plus human granulocyte colony stimulating factor显示文摘 | Haider K Kornek GV Kwasny W | 1999 | Breast Cancer Res Treat1999，55，3： | 1 |
| 9 | Serum retinol-binding protein 4 is reduced after weight loss in morbidly obese subjects显示文摘 | Haider DG Schindler K Prager G | 2007 | J Clin Endocrinol Metab2007，92，3： | 1 |
| 10 | Treatment of advanced breast cancer with docetaxel and gemcitabine with and without human granulocyte colony-stimulating factor 显示文摘 | Kornek GV Haider K Kwasny W | 2002 | Clin Cancer Res2002，8，： | 1 |
| 11 | Preparationof amidoxime-modified polyacrylonitrile ( PAN-oxime )nanofibers and their applications to metal ions adsorp-tion 显示文摘 | SAEED K HAIDER S PARK S Y | 2008 | Journal of Membrane Science2008，，322： | 1 |
| 12 | Swelling and elec- troresponsive characteristics of gelatin immobilized onto multi walled carbon nanotubes 显示文摘 | Haider S Park S Y Saeed K | 2007 | Sensor Actuator B2007，124，2： | 1 |
| 13 | The effect of seeing a family physician on the level of glycosylated hemoglobin (HbA1c) in type 2 Diabetes Mellitus patients显示文摘 | Mahdavi AR Etemad K Haider M | | 0，，： | 1 |
| 14 | Effect of rosiglitazone on visfatin and retinol-binding protein-4 plasma concentrations in HIV-positive patients 显示文摘 | Haider DG Schindler K Mittermayer F | 2007 | Clin Pharmacol Ther2007，81，4： | 1 |
| 15 | Identification of multiple rare earth sand associated elements in raw Monazite sands by laser-induced break down spectroscopy 显示文摘 | Abedin K M Haider M Y Rony M A | 2011 | Optics & Laser Technology2011，43，14： | 1 |
| 16 | Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury显示文摘 | Salahudeen A K Haider N Jenkins J | 2008 | Am J Physiol Renal Physiol2008，294，6： | 1 |
| 17 | Fatal hemolysis after highdose etoposide:is benzyl alcohol to blame显示文摘 | Smith AL Haider K Schachtner JM | 2001 | Pharmacotherapy2001，21，6： | 1 |
| 18 | Catechol and chlorocatechols in soil: Degradation and Extractability显示文摘 | CHENG H H HAIDER K HARPER S S | 1983 | Soil Biology and Biochemistry1983，15，3： | 1 |
| 19 | Rotating platibrm versus fixed-bearing total knees: an in vitro study of wear显示文摘 | Haider H Garvin K | 2008 | Clin Orthop Relat Res2008，11，： | 1 |
| 20 | Plasmid-mediated resistance to nalidixic acid in Shigella dysenteriae type 1显示文摘 | Munshi MH Sack DA Haider K | 1987 | Lancet1987，2，8556： | 1 |
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