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| 1 | FragAnchor: A Large-Scale Predictor of Glycosylphosphatidylinositol Anchors in Eukaryote Protein Sequences by Qualitative Scoring显示文摘A glycosylphosphatidylinositol (GPI) anchor is a common but complex C-terminal post-translational modification of extracellular proteins in eukaryotes. Here we investigate the problem of correctly annotating GPI-anchored proteins for the growing number of sequences in public databases. We developed a computa- tional system, called FragAnchor, based on the tandem use of a neural net- work (NN) and a hidden Markov model (HMM). Firstly, NN selects potential GPI-anchored proteins in a dataset, then HMM parses these potential GPI sig- nals and refines the prediction by qualitative scoring. FragAnchor correctly predicted 91% of all the GPI-anchored proteins annotated in the Swiss-Prot database. In a large-scale analysis of 29 eukaryote proteomes, FragAnchor predicted that the percentage of highly probable GPI-anchored proteins is between 0.21% and 2.01%. The distinctive feature of FragAnchor, compared with other systems, is that it targets only the C-terminus of a protein, making it less sensitive to the background noise found in databases and possible incomplete protein sequences. Moreover, FragAnchor can be used to predict GPI-anchored proteins in all eukaryotes. Finally, by using qualitative scoring, the predictions combine both sensitivity and information content. The predictor is publicly available at http://gffzz1607d9a456694c4ch0cnxw59p6pnw66nv.ffgz.tsg.suse.edu.cn/~fraganchor/NNHMM/NNHMM.html. | Guylaine Poisson Cedric Chauve Xin Chen Anne Bergeron | 2007 | Genomics, Proteomics & Bioinformatics2007，5，2： | 3 |
| 2 | DNA Ssequencing,and Expression of Thermostable β-Mannanase from Bacillus stearothermophilus显示文摘 | Nathalie Ethier Guylaine Talboi and Jurgen Sygusch Gene Cloning | 1998 | Applied and Environmetal Microbiology1998，64，11： | 1 |
| 3 | Bacterial co- mmunity dynamics in an anaerobic plug-flow type bioreactor treating swine manure 显示文摘 | Caroline S R Guylaine T Edward T | 2009 | Water Res2009，43，1： | 1 |
| 4 | High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1显示文摘 | Guylaine Bouchard Heather M. Nelson Frank Lammert Lucy B. Rowe Martin C. Carey Beverly Paigen | 1999 | Mammalian Genome1999，，11： | 1 |
| 5 | Supracervical Hys-terectomy显示文摘 | Sari Kives M D Guylaine Lefebvre M D | 2010 | JOGC2010，，： | 1 |
| 6 | Gene cloning, DNA sequencing, and expression of thermostable fl -mannanase from Bacillus stearothermophilus 显示文摘 | Nathalie Ethier Guylaine Talbot Jurgen Sygusch | 1998 | Applied and Environment Microbiology1998，64，11： | 1 |
| 7 | High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1显示文摘 | Guylaine Bouchard Heather M. Nelson Frank Lammert Lucy B. Rowe Martin C. Carey Beverly Paigen | 1999 | Mammalian Genome1999，，11： | 1 |
| 8 | Anasso ciative polyelectrolyte end-capped with short polystyrene chains:Synthesis and rheological behavior显示文摘 | Tsitsilianis Constantinos Iliopoulos Ilias Ducouret Guylaine | 2000 | Macromolecules2000，33，： | 1 |
| 9 | Defects in a weld: a complete Radiographic Processing Line 显示文摘 | Guylaine Daillant etc al | 1996 | IEEE1996，，： | 1 |
| 10 | Immobilization of chromium(Ⅵ)evaluated by binding isotherms for ground granulated blast furnace slag and ordinary Portland cement显示文摘 | Guylaine Laforest Jose Duchesne | 2005 | Cement and Concrete Research2005，35，： | 1 |
| 11 | Bacterial community dynamics in an anaerobic plug-? ow type bioreactor treating swine manure 显示文摘 | CAROLINE S R GUYLAINE T EDWARD T | 2008 | Water Research2008，43，： | 1 |
| 12 | Body mass index may overestimate the prevalence of overweight and obesity among the inuit显示文摘 | Guylaine CR Helga SU Harriet V | 2005 | Int J Heal2005，64，2： | 1 |
| 13 | Effect of dietary lecithin on plasma lipid transport and hepatic cholesterol metabolism in rats显示文摘 | Marie-Josee'e L Sylvain B Guylaine B | 2003 | Journal of Nutritional Biochemistry2003，14，： | 1 |
| 14 | An associative polyelectrolyte,end-capped with short polystyrene chains:synthesis and rheological behavior显示文摘 | Tsitsilianis Constantion Iliopoulos Ducourer Guylaine | 2000 | Macro molecules2000，，： | 1 |
| 15 | 落叶松立木材积方程非线性和对数转换的对比显示文摘以兴安落叶松立木材积方程为研究对象,采用Ballantyne提出的似然分析法判断落叶松立木材积方程是否需要进行对数转换。结果表明:经似然分析法判断,落叶松立木材积方程需要进行对数转换。然而对非线性和对数转换线性模型拟合和检验统计量的比较表明:非线性和对数转换线性立木材积模型拟合评价指标非常接近。非线性立木材积模型的拟合和检验精度略高于对数转换的线性模型。立木材积模型的主要应用是用来预测,建议选择非线性回归分析。 | Enzinga Yolo Guylain 辛士冬 姜立春 | 2019 | 东北林业大学学报2019，47，4： | 1 |
| 16 | Human mesenchymal stem cells (hMSC) exhibit myogenic differentiation when implanted in infarcted rat myocardium显示文摘 | Bradley M Guylaine S Mark P | 1999 | Circulation1999，110，： | 1 |
| 17 | An associative polyelectrolyte, endcapped with short polystyrene chains: synthesis and rheological behavior 显示文摘 | Iliopoulos T C Guylaine D | 2000 | Macromolecules2000，33，： | 1 |
| 18 | Gene cloning, DNA sequencing and expression of thermostable β-mannanase from Bacillus stearothermophilus 显示文摘 | NATHALIE ETHIER GUYLAINE TALBOI JURGEN SYGUSCH | 1998 | Applied and Envinmmetal Microbiology1998，64，11： | 1 |
| 19 | High rate of complicated idiopathic gallstone disease in pediatric patients of a North American tertiary care center显示文摘AIM: To assess spectrum and etiology of gallstones and biliary sludge in the pediatric population of a North American tertiary care centre. METHODS: Retrospective review of abdominal ultraso- unds recorded at Saint Justine Hospital over a period of 24 mo (8/2003 to 8/2005) in patients < 19 years of age. Patients < 2 years of age were analyzed separately. RESULTS: The presence of gallstones was noted in 127 patients. In 107 it was a new diagnosis, in 48/105 (45.7%) patients > 2 years of age idiopathic gallstone disease was found. These 48 patients represent 2.1% of the population who required ultrasound for abdominal pain. Complicated gallstone disease occurred in 28/48 with idiopathic disease, mainly adolescent girls. Patients with hemolytic disorders, cystic fibrosis, oncologic diseases or kidney transplantation and gallstones were asymptomatic and stones were detected during routine abdominal ultrasound. Twenty two patients < 2 years of age not consulting for abdominal pain had gallstone disease of diverse etiology. Biliary sludge was seen in 84 patients, 78.5% on total parenteral nutrition. In 4 patients, sludge progressed to gallstones. CONCLUSION: Idiopathic gallstone disease and its rate of complication are more frequent in our cohort than expected from previous studies. Adolescent girls with abdominal pain and idiopathic gallstones require special attention for complicated disease course. | Denise Herzog Guylaine Bouchard | 2008 | World Journal of Gastroenterology2008，14，10： | 1 |
| 20 | Bacterial community dynamics in an anaerobic plug-flow type biore- actor treating swine manure 显示文摘 | S R Caroline T Guylaine T Edward | 2009 | Water Research2009，43，： | 1 |
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