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| 1 | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity显示文摘Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially macrophages.Immune molecules,including some cytokines,have a close relationship with metabolism.Interleukin(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively clarified.Human serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in vitro.IL-25 was decreased in NAFLD patients and obese mice.In addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating macrophages.IL-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated macrophages.Furthermore,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and ATP.In conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes. | Juan Feng Lingyi Li Zhiying Ou Qiao Li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun Zhong Weibin Cai Xia Yang Aiping Zhao Guoquan Gao Zhonghan Yang | 2018 | Cellular & Molecular Immunology2018，15，5： | 10 |
| 2 | Second-harmonic generation using d(33)in periodically poled lithium niobate microdisk resonators显示文摘A fabrication process allowing for the production of periodically poled lithium niobate(PPLN)photonic devices with any domain pattern and unit size down to 200 nm is developed by combining semiconductor fabrication techniques and piezo-force-microscopy tips polarization.Based on this fabrication process,PPLN microdisk resonators with quality factors of 8×10~4 were fabricated from a Z-cut lithium niobate film.Second-harmonic generation(SHG)utilizing d(33)in the whole cavity was demonstrated in a PPLN microdisk with a 2μm-spatialperiod radial domain pattern.The SHG conversion efficiency was measured to be 1.44×10^(-5)m W^(-1).This work paves the way to fabricate complex PPLN photonic devices and to obtain efficient nonlinear optical effects that have wide applications in both classical and quantum optics. | ZHENZHONG HAO LI ZHANG WENBO MAO ANG GAO XIAOMEI GAO FENG GAO FANG BO GUOQUAN ZHANG JINGJUN XU | 2020 | Photonics Research2020，8，3： | 6 |
| 3 | Periodically poled lithium niobate whispering gallery mode microcavities on a chip显示文摘In this study, we investigate the fabrication of periodically poled lithium niobate(PPLN) microdisk cavities on a chip. These resonators are fabricated from a PPLN film with a 16 μm poling period on insulator using conventional microfabrication techniques.The quality factor of the PPLN microdisk resonators with a 40-μm radius and a 700-nm thickness is 6.7×10~5. Second harmonic generation(SHG) with an efficiency of 2.2×10^(-6) mW(-1) is demonstrated in the fabricated PPLN microdisks. The nonlinear conversion efficiency could be considerably enhanced by optimizing the period and pattern of the poled structure and by improving the cavity quality factors. | ZhenZhong Hao Li Zhang Ang Gao WenBo Mao XiaoDan Lyu XiaoMei Gao Fang Bo Feng Gao GuoQuan Zhang JingJun Xu | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，11： | 5 |
| 4 | Integrated lithium niobate single-mode lasers by the Vernier effect显示文摘Microcavity lasers based on erbium-doped lithium niobate on insulator(LNOI),which are key devices for LNOI integrated photonics,have attracted significant attention recently.In this study,we report the realization of a C-band single-mode laser using the Vernier effect in two coupled erbium-doped LNOI microrings with different radii under the pump of a 980-nm continuous laser.The laser,operating stably over a large range of pumping power,has a pump threshold of about 200μW and a side-mode suppression ratio exceeding 26 dB.The high-performance LNOI single-mode laser will promote the development of lithium niobate integrated photonics. | Ru Zhang Chen Yang ZhenZhong Hao Di Jia Qiang Luo DaHuai Zheng HongDe Liu XuanYi Yu Feng Gao Fang Bo YongFa Kong GuoQuan Zhang JingJun Xu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，9： | 4 |
| 5 | Sum-frequency generation in on-chip lithium niobate microdisk resonators显示文摘We report the first observation, to the best of our knowledge, of sum-frequency generation in on-chip lithium niobate microdisk resonators. The sum-frequency signal in the 780 nm band, distinct in wavelength from secondharmonic signals, was obtained in lithium niobate microresonators under the pump of two individual 1550 nm band lasers. The sum-frequency conversion efficiency was measured to be 1.4 × 10^(-7) mW^(-1). The dependence of the intensities of the nonlinear signals on the total pump power and the wavelength of one pump laser was investigated while fixing the wavelength of the other. This work paves the way for applications of on-chip lithium niobate microdisk resonators ranging from infrared single-photon detection to infrared spectroscopy. | ZHENZHONG HAO JIE WANG SHUQIONG MA WENBO MAO FANG BO FENG GAO GUOQUAN ZHANG JINGJUN XU | 2017 | Photonics Research2017，5，6： | 3 |
| 6 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 7 | Process simulation and energy integration in the mineral carbonation of blast furnace slag显示文摘Large quantities of blast furnace(BF) slag and CO_2 are discharged annually from iron and steel industries, along with a large amount of waste heat.The mineral carbonation of BF slag can not only reduce emissions of solid waste but also realize the in-situ fixation of CO_2 with low energy consumption if integrated with the waste heat utilization.In this study, based on our previous works, Aspen Plus was employed to simulate and optimize the carbonation process and integrate the process energy.The effects of gehlenite extraction, MgSO_4 carbonation,and aluminum ammonium sulfate crystallization were studied systematically.The simulation results demonstrate that 2.57 kg of BF slag can sequester 1 kg of CO_2, requiring 5.34 MJ of energy(3.3 MJ heat and 2.04 MJ electricity), and this energy includes the capture of CO_2 from industrial flue gases.Approximately 60 kg net CO_2 emission reduction could be achieved for the disposal of one ton of BF slag.In addition, the by-product,aluminum ammonium sulfate, is a high value-added product.Preliminary economic analysis indicates that the profit for the whole process is 1127 CNY per ton of BF slag processed. | Jianqiu Gao Chun Li Weizao Liu Jinpeng Hu Lin Wang Qiang Liu Bin Liang Hairong Yue Guoquan Zhang Dongmei Luo Siyang Tang | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 2 |
| 8 | Mode characteristics of silver-coated inverted-wedge silica microdisks显示文摘The characteristics of whispering gallery modes(WGM) in silver-coated inverted-wedge silica microdisks are theoretically investigated by using finite element method. Dielectric TE mode always exists in silver-coated inverted-wedge resonators; dielectric TM mode tends to couple with SPP modes; only pure interior surface plasmonic polariton(SPP) mode but not pure exterior SPP mode is observed in contrast to the metal-coated cylindrical and toroidal resonators. The dependence of quality factor of different kinds of WGMs on the radius of the resonator and the thickness of the coated silver layer are systematically analyzed. We find that the quality factors of the hybrid WGMs associated with SPP mode can reach 104. The maximum light intensity enhancement in ambient for a hybrid mode consisting of a dielectric TM mode and an exterior SPP mode can be obtained when a silver film of thickness ~40 nm is deposited. The silver-coated inverted-wedge silica resonators may be widely applied in sensing and surface enhanced Raman scattering. | BO Fang WANG XiaoOu LI Ying GAO Feng ZHANG GuoQuan XU JingJun | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，11： | 2 |
| 9 | A functional polymorphism in MIR 196 A 2 is associated with risk and prognosis of gastric cancer显示文摘 | Shizhi Wang Guoquan Tao Dongmei Wu Haixia Zhu Yan Gao Yongfei Tan Meilin Wang Weida Gong Yan Zhou Jianwei Zhou Zhengdong Zhang | 2013 | Mol Carcinog2013，，1： | 1 |
| 10 | Developing a strong anion exchange/RP (SAX/RP) 2D LC system for high‐abundance proteins depletion in human plasma显示文摘 | Shaochun Zhu Xueyang Zhang Mingxia Gao Guangfeng Hong Guoquan Yan Xiangmin Zhang | 2012 | Proteomics (-)2012，，23： | 1 |
| 11 | Polarization-modified Fano line shape spectrum with a single whispering gallery mode显示文摘Using the HE11Xand HE11Ymodes in a tapered fiber(TF)and the whispering gallery mode(WGM)in a microsphere resonator,Fano line-shape spectra were theoretically described and experimentally observed in this study.The line shapes of the spectra can be tuned to form a Lorentz notch,various Fano line shapes,and the Lorentz peak by controlling the polarizations at the input and output ports of the TF.The relative position or the size of the waveguide and WGM resonator do not need to be accurately controlled to produce these effects.The proposed configuration is suitable for mass production and will improve the performance of the devices in which it is applied. | PengFa Chang BoTao Cao LiGang Huang JiWei Li Yue Hu Feng Gao WenDing Zhang Fang Bo XuanYi Yu GuoQuan Zhang JingJun Xu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，1： | 1 |
| 12 | Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization显示文摘 | Guoquan Gao Yan Li Jian-xing Ma | 2001 | FEBS Lett2001，489，： | 1 |
| 13 | Advances in Research of Garlic Virus Diseases显示文摘Garlic virus infection is an important disease which affects garlic production,with the increasing years of planting,harm of virus is serious year by year,which seriously affect yield and quality of garlic.In order to know the garlic virus effectively,the paper reviewed the research situation of several important garlic virus in virus species,origin,distribution,host range,symptom,route of transmission,classification,genome and detection technique and the prevention technology of garlic viruses.At the same time,prospected several important research aspects of garlic virus in the future. | BAI Yanju 1,ZHANG Wei 1,LI Xuezhan 1,SHEN Yu 1,GAO Yanling 1,FAN Guoquan 1,GENG Hongwei 1,and MENG Xianxin 2 1 Virus-free Seeding Research Institute of Heilongjiang Agricultural Sciences,Harbin 150086,China 2 Crop Breeding Institute of Heilongjiang Academy of Agricultural Sciences,Harbin 150086,China | 2010 | Journal of Northeast Agricultural University(English Edition)2010，17，2： | 1 |
| 14 | SERPINA 3 K induces apoptosis in human colorectal cancer cells via activating the F as/ F as L /caspase‐8 signaling pathway显示文摘 | Yachao Yao Lei Li Xuan Huang Xiaoqiong Gu Zumin Xu Yang Zhang Lijun Huang Shuai Li Zhiyu Dai Cen Li Ti Zhou Weibin Cai Zhonghan Yang Guoquan Gao Xia Yang | 2013 | FEBS J2013，，14： | 1 |
| 15 | Indentation behavior of a semi-infinite piezoelectric semiconductor under a rigid flat-ended cylindrical indenter显示文摘This paper theoretically studies the axisymmetric frictionless indentation of a transversely isotropic piezoelectric semiconductor(PSC)half-space subject to a rigid flatended cylindrical indenter.The contact area and other surface of the PSC half-space are assumed to be electrically insulating.By the Hankel integral transformation,the problem is reduced to the Fredholm integral equation of the second kind.This equation is solved numerically to obtain the indentation behaviors of the PSC half-space,mainly including the indentation force-depth relation and the electric potential-depth relation.The results show that the effect of the semiconductor property on the indentation responses is limited within a certain range of variation of the steady carrier concentration.The dependence of indentation behavior on material properties is also analyzed by two different kinds of PSCs.Finite element simulations are conducted to verify the results calculated by the integral equation technique,and good agreement is demonstrated. | Shijing GAO Lele ZHANG Jinxi LIU Guoquan NIE Weiqiu CHEN | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，4： | 0 |
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