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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 3 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 4 | Insights from avian influenza surveillance of chickens and ducks before and after exposure to live poultry markets显示文摘Dear Editor, Live poultry markets are the major trading system of poultry in China and many other countries, and are also thought to be important for the generation and spread of avian influenza viruses and other avian pathogens (Zhang et al., 2013;Shi et al., 2017;Quan et al., 2018). | Mei Li Xin Yin Lizheng Guan Xia Zhang Guohua Deng Tao Li Pengfei Cui Yong Ma Yujie Hou Jianzhong Shi Hualan Chen | 2019 | Science China(Life Sciences)2019，62，6： | 6 |
| 5 | Short-Range Multitarget Motion Parameter Estimation Method Based on Hough Transform显示文摘This study proposes a novel short-range multitarget motion parameter estimation method based on Hough transform. The proposed method can be used for multitarget detection, motion parameter estimation, and data association. In our proposed method, the measured radial distance and Doppler frequency versus time data is mapped to the motion parameter space by Hough transform. The motion parameter space data is binarized to determine the number of targets. The unsupervised nearest neighbor clustering technique is used to determine the search space of targets. The maximum value in each search space is estimated as the motion parameter of the corresponding target. Simulation results show that the proposed method has higher parameter estimation accuracy than that of conventional methods. | LYU Peng WEI Guohua CUI Wei | 2019 | Chinese Journal of Electronics2019，28，2： | 4 |
| 6 | Polyimide separators for rechargeable batteries显示文摘Separators are indispensable components of modern electrochemical energy storage devices such as lithium-ion batteries(LIBs).They perform the critical function of physically separating the electrodes to prevent short-circuits while permitting the ions to pass through.While conventional separators using polypropylene(PP) and polyethylene(PE) are prone to shrinkage and melting at relatively high temperatures(150℃ or above) causing short circuits and thermal runaway,separators made of thermally stable polyimides(PIs) are electrochemically stable and resistant to high temperatures,and possess good mechanical strength-making them a promising solution to the safety concerns of LIBs.In this review,the research progress on PI separators for use in LIBs is summarized with a special focus on molecular design and microstructural control.In view of the significant progress in advanced chemistries beyond LIBs,recent advances in PI-based membranes for applications in lithium-sulfur,lithium-metal,and solid-state batteries are also reviewed.Finally,practical issues are also discussed along with their prospects. | Ziheng Lu Fan Sui Yue-E Miao Guohua Liu Cheng Li Wei Dong Jiang Cui Tianxi Liu Junxiong Wu Chunlei Yang | 2021 | Journal of Energy Chemistry2021，30，7： | 3 |
| 7 | Phospholipid Transfer Protein Deficiency Decreases the Content of S1P in HDL via the Loss of its Transfer Capability显示文摘 | Yang Yu Shoudong Guo Yumei Feng Lei Feng Yingjie Cui Guohua Song Tian Luo Ke Zhang Yiwei Wang Xian-Cheng Jiang Shucun Qin | 2014 | Lipids2014，，2： | 2 |
| 8 | Trust Calculation and Delivery Control in Trust-Based Access Control显示文摘Trust management system has been a promising approach to solve the access control problems in open multi-domain environments. However, the calculation of trust and the delivery of the trust are not addressed effectively in the existing trust management systems. To address the problems, this paper proposes a scheme of trust calculation and delivery control. Compared with the other schemes, it is simpler and more flexible, and also easier to be implemented. | LEI Jianyun CUI Guohua XING Guanglin | 2008 | Wuhan University Journal of Natural Sciences2008，13，6： | 2 |
| 9 | A more efficient accountable authority IBE scheme under the DL assumption显示文摘In 2007, Goyal introduced a new and creative approach, called accountable authority identity-based encryption (referred to as A-IBE), to reduce the degree of trust that must be placed in the private-key generator (PKG) in an identity-based encryption (IBE) scheme. Based on his work, a new universal A-IBE scheme is proposed in this paper. Compared with Goyal's universal scheme, this new universal A-IBE scheme not only optimizes the time requirements for pairing operations, but also achieves a 'tighter' security reduction based on a weaker hard problem (the discrete logarithm problem) under a stronger security definition (using an adaptively selected identity). Because there are many fewer pairing operations in this new scheme, the performance of the application can be improved to some degree. In addition, because of the 'tighter' security reduction achieved by this new proposed scheme, a less restrictive security parameter can be chosen while achieving the same security as with Goyal's scheme along with an improvement in performance. In the respect of the time requirement, compared with the Goyal's universal scheme, this new scheme could be more efficient. Regrettably, these improvements will increase the memory needed for the public parameters and the volume of communications required. Compromise values of the public parameters should therefore be chosen to balance the advantages and drawbacks. | XU Peng, CUI GuoHua, FU Cai & TANG XueMing Laboratory of Information Security, College of Computer Science, Huazhong University of Science and Technology, Wuhan 430074, China | 2010 | Science China(Information Sciences)2010，53，3： | 2 |
| 10 | Processing thermalstability and degradation kinetics of PVC/montmorillonite Composites显示文摘 | Chaoying Wan Guohua Tian Ning Cui | 2004 | J Appl Polym Sci2004，92，3： | 1 |
| 11 | Electrochemical degradation of bisphenol A on different anodes显示文摘 | Cui Yuhong Li Xiaoyan Chen Guohua | 2009 | Water Research2009，43，： | 1 |
| 12 | Stiffness, workspace analysis and optimization for 3UPU parallel robot mechanism显示文摘 | Cui Guohua Wei Bin Wang Nan | 2013 | Indonesian Journal of Electrical Engineering2013，11，9： | 1 |
| 13 | Resonant mode analysis of the nanoseale surface plasmon polariton waveguide filter with rectangle cavity显示文摘 | Yun Binfeng Hu Guohua Cui Yiping | 2013 | Plasmonics2013，8，2： | 1 |
| 14 | A Proxy Blind Signature Schemes Based DLP and Applying in e-Voting显示文摘 | Shaobin Wang Hong Fan Guohua Cui | 2005 | ICEC2005，，： | 1 |
| 15 | High output-regulation accuracy and fast transient response of dual constant on-time controlled switching converter显示文摘 | ZHOU Guohua CHEN Xing CUI Hengfeng | 2014 | Electronics Letters2014，50，7： | 1 |
| 16 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells显示文摘 | Shuguang Zuo Chang Liu Jianguo Wang Fuqing Wang Wanling Xu Shao Cui Lei Yuan Xudong Chen Wenjuan Fan Mingchen Cui Guohua Song | 2012 | Journal of Cancer Research and Clinical Oncology2012，，6： | 1 |
| 17 | Electrochemical degradation of refractory pollutant using a novel microstructured TiO2 nanotubes/Sb-doped SnO2 electrode 显示文摘 | Zhao Guohua Cui Xiao Liu Meichuan | 2009 | Environ Sci Technol2009，43，： | 1 |
| 18 | Merkle Tree Digital Signature and Trusted Computing Platform显示文摘在起始的关键产生过程的效率的缺乏是有很多可能的签名的 Merkle 树签名计划的一个严肃的缺点。基于二种 Merkle 树,一个新树类型签名计划被构造,并且它是 provablyexistentially,在适应选择消息下面的 unforgeable 攻击。由分散在签名过程以内的原来的计划的起始的关键产生过程,有 6.87 X 10 ~(10 ) 的一棵大 Merkle 树可能的签名能在 590 毫秒被初始化。在硬盘和存储器存储一些小 Merkletrees 能加快 Merkle 树签名计划。Mekle 树签名计划为在大多数情形计算站台信任是合适的。 | WANG Xiaofei HONG Fan TANG Xueming CUI Guohua | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 1 |
| 19 | A poly- meric optical switch array based on arrayed waveguide grating structure 显示文摘 | Hu Guohua Cui Yiping Yun Binfeng | 2007 | Optics Communications2007，279，： | 1 |
| 20 | Threshold Subliminal Channel Based on Designated Verifier Signature显示文摘The subliminal channel is used to send a secret message to an authorized receiver; the message cannot be discovered by any unauthorized receivers. Designated verifier signature(DVS) provide authentication of a message, we design a DVS scheme with message recovery mechanism and use it as a subliminal channel. In order to share a message among n users securely and allows t or more users can reconstruct the secret in dynamic groups, we combine both subliminal channel and (t, n) threshold cryptography. Then we proposed a threshold subliminal channel which can convey a subliminal message to a group of users based on message-recovery designated verifier signatures. Reconstructing the subliminal message relies on the cooperation of t or more users in the group and they can verify the validity of the subliminal message. Security and performance analysis show that the proposed scheme is secure and efficient. | SU Li CUI Guohua YANG Muxiang CHEN Jing | 2006 | Wuhan University Journal of Natural Sciences2006，11，6： | 1 |
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