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| 1 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 2 | Jiaotai Pill (交泰丸) Alleviates Insomnia through Regulating Monoamine and Organic Cation Transporters in Rats显示文摘Objective To reveal the effect and mechanism of Jiaotai Pill(交泰丸,JTP)on insomniac rats.Methods The insomniac model was established by intraperitoneal injection of p-chlorophenylalanine(PCPA).In behavioral experiments,rats were divided into control,insomniac model,JTP[3.3 g/(kg•d)],and diazepam[4 mg/(kg•d)]groups.The treatment effect of JTP was evaluated by weight measurement(increasement of body weight),open field test(number of crossings)and forced swimming test(immobility time).A high performance liquid chromatography-electrochemical detection(HPLC-ECD)method was built to determine the concentration of monoamine transmitters in hypothalamus and peripheral organs from normal,model,JTP,citalopram[30 mg/(kg•d)],maprotiline[40 mg/(kg•d)]and bupropion[40 mg/(kg•d)]groups.Expressions of serotonin transporter(SERT),dopamine transporter(DAT),and norepinephrine transporter(NET)were analyzed by quantitative polymerase chain reaction(qPCR)and Western blot in normal,model and JTP groups.A high performance liquid chromatography-electrospray ionization mass spectrometry(HPLC-ESI-MS/MS)method was established to determine the pharmacokinetics,urine cumulative excretion of metformin in vivo,and tissue slice uptake in vitro,which were applied to assess the activity of organic cation transporters(OCTs)in hypothalamus and peripheral organs.Results Compared with the insomniac model group,the body weight and spontaneous locomotor were increased,and the immobility time was decreased after treatment with JTP(P<0.01).Both serotonin and dopamine contents in hypothalamus and peripheral organs were increased(P<0.01).The norepinephrine content was increased in peripheral organs and decreased in hypothalamus(P<0.05 or P<0.01).At the same time,SERT,DAT,OCT1,OCT2,and OCT3 were down-regulated in hypothalamus and peripheral organs(P<0.05).NET was down-regulated in peripheral organs and up-regulated in hypothalamus(P<0.05 or P<0.01).Moreover,the activity of OCTs in hypothalamus and peripheral organs was inhibited(P<0.05).Conclusion JTP alleviates insomnia through regulation of monoaminergic system and OCTs in hypothalamus and peripheral organs. | LI Zhi-hui MA Peng-kai HUANG Yun-fang ZHANG Zhe ZHENG Wei CHEN Jian-hua GUO Chang-e CHEN Ning Bl Xin-ning ZHANG Yu-jie | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 3 |
| 3 | A closer look to botulinum neurotoxin type A-induced analgesia显示文摘 | Guo BL Zheng CX Sui BD | 2013 | Toxicon2013，9，71： | 1 |
| 4 | Upregulates the Expression of Osteoprotegerin in Mouse Osteoblasts MC3T3-E1 Through PKC/MAPK Pathways显示文摘 | Dan LM Yang AW Guo BL | 2012 | Biol Trace Elem Res2012，146，： | 1 |
| 5 | The predictive value of p16 (INK4a) and hybrid capture 2 human papillomavirus testing for high-grade cervical in- traepithelial neoplasia显示文摘 | Guo M Hu L Baliga bl | 2004 | Am J Clin Pathol2004，122，6： | 1 |
| 6 | Ex vivo expanded human Vgamma9Vdelta2 + gammadelta-T cells mediate innate antitumor activity against human prostate cancer ceils in vitro 显示文摘 | Liu Z Guo BL Gehrs BC | 2005 | J Urol2005，173，5： | 1 |
| 7 | Neurotrophic factors interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation显示文摘 | Guo Q Sebastian L Sopher BL | 1999 | Proc Natl Acad Sci USA1999，96，7： | 1 |
| 8 | Diagnosticvalue of alpha-fetoprotein-L3 and Golgi protein 73 in hep- atocellular carcinomas with low AFP levels显示文摘 | Xu WJ Guo BL Han YG | 2014 | Turnout Biol2014，35，12： | 1 |
| 9 | Transforming growth factor-beta 1 gene polymorphisms and cardiovascular disease in hemodialysis patients 显示文摘 | Rao M Guo D Jaber BL | 2004 | Kidney Int2004，66，1： | 1 |
| 10 | A Single Point Mutation in e-COP Results in Temperature-sensitive,Lethal Defects in Membrane Transport in a Chinese Hamster Ovary Cell Mutant显示文摘 | Guo Q Penman M Trigatti BL | | 0，，19： | 1 |
| 11 | Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide显示文摘 | Guo Q Furukawa K Sopher BL | 1996 | Neuroreport1996，8，1： | 1 |
| 12 | Simultaneous determination of 15 flavonoids in Epirnedium using pressurized liquid extraction and high-performance liquid chromatography显示文摘 | Chen XJ Guo BL Li SP | 2007 | J Chromatogr A2007，1163，12： | 1 |
| 13 | ^99Tc^mdirect labeling of Annexin V for potential apoptosis imaging in vivo(Abstract) 显示文摘 | Zhu L Liu BL Guo YZ | 2003 | J Labeled Comp Radiopham2003，46，： | 1 |
| 14 | Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species 显示文摘 | P Shen BL Guo Y Gong | 2007 | Phytochemistry2007，68，10： | 1 |
| 15 | ^99Tc^m direct labeling of Annexin V for potential apoptosis imaging in vivo 显示文摘 | Zhu L Liu BL Guo YZ | 2003 | J Labelled Comp Radio-pharm2003，46，1： | 1 |
| 16 | Fast quality control of Herba Epimediiby using Fourier transform infrared spectroscopy 显示文摘 | Pei LK Sun SQ Guo BL | 2008 | Spectrochim Acta Part A2008，70，2： | 1 |
| 17 | Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity :central roles of superoxide production and caspase activation显示文摘 | Guo Q Sebastian L Sopher BL | 1999 | J Neurochem1999，72，3： | 1 |
| 18 | MicroRNA-mediated controlof cell fate in megakaryocyte-erythrocyte progenitors 显示文摘 | Lu J Guo S Ebert BL | 2008 | Dev Cell2008，14，： | 1 |
| 19 | Proteomic analysis of SUM04 sub- strates in HEK293 ceils under serum starvation-induced stress 显示文摘 | Guo D Han J Adam BL | 2005 | Biochem Biophys Res Commun2005，337，4： | 1 |
| 20 | An &daptive security end-system model b&sed On Active defense显示文摘 | Hu HP Limng X Zhang BL Guo WX | 2004 | Communications Systems2004，45，6： | 1 |
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