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您的检索式：作者名="Guilai Chen"
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| 1 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 2 | Short-term Breakdown and Long-tem Failure in Nanodielectrics: A Review 显示文摘 | LI SHENGTAO YIN GUILAI CHEN G | 2010 | IEEE Transactions on Dielectrics and Electrical Insulation2010，17，5： | 1 |
| 3 | Induced Pluripotency for Translational Research显示文摘The advent of induced pluripotent stem cells(iPSCs)has revolutionized the concept of cellular reprogramming and potentially will solve the immunological compatibility issues that have so far hindered the application of human pluripotent stem cells in regenerative medicine.Recent fndings showed that pluripotency is defned by a state of balanced lineage potency,which can be artifcially instated through various procedures,including the conventional Yamanaka strategy.As a type of pluripotent stem cell,iPSCs are subject to the usual concerns over purity of differentiated derivatives and risks of tumor formation when used for cell-based therapy,though they provide certain advantages in translational research,especially in the areas of personalized medicine,disease modeling and drug screening.iPSC-based technology,human embryonic stem cells(hESCs)and direct lineage conversion each will play distinct roles in specifc aspects of translational medicine,and continue yielding surprises for scientists and the public. | Menghua Wu Guilai Chen Baoyang Hu | 2013 | Genomics, Proteomics & Bioinformatics2013，11，5： | 1 |
| 4 | THE EFFECTS OF COMBINING APPLICATION OF DIAGNOSIS AND TREATMENT TECHNOLOGIES OF ERP AND PSYCHIC REHABILITATION INTERVENTION ON REHABILITATION OF SCHIZOPHRENIA显示文摘Objective:To explore the effects of combining application of diagnosis and treatment technologies of Event Related Potentials(ERP)and Psychic Rehabilitation Intervention(PRI)on rehabilitation of schizophrenia.Methods:PRI and ERP were used in schizophrenia rehabilitation in this research.232 patients were divided into study group(SG)and control group(CG),and the rehabilitation effects were compared.Results:(1)After the implementation of the PRI,more score of the Brief Psychiatric Rating Scale(BPRS)was reduced on SG than the score on CG;more decreased scores of insight and on Social Disability Screening Schedule(SDSS),and more increased scores of treatment compliance questionnaire scores were observed on SG,comparing with CG(P<0.05 or 0.01).(2)After the implementation of the PRI,more decreased factor scores of Symptom Checklist 90 were observed on SG patients family members(P<0.05 or 0.01).(3)PRI significantly improved the patients’social functions,family members’relationship and prevented the recurrence of schizophrenia.(4)Improved P2,P3 amplitudes were also detected on SG compared with CG(P<0.05).Conclusions:(1)PRI interventions may improve schizophrenia patients’social function.(2)ERP may be used to evaluate the schizophrenia patients’rehabilitation,and is worth being popularized. | Song Lisheng Zhang Chen Chen Meijuan Zhang Yi Li Xiaoping Zhao Wenqing Yang Xujiao Huang Xinrui Lin Xiaodong Chen Ce Wang Xiwu Wu Rongqin Xu Lu Tang Jialin Wang Zuowei Zhan Guilai Zhang Zhanxing He Qiuhao | 2019 | 现代电生理学杂志2019，26，B03： | 0 |
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