| 1 | HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas显示文摘Hepatocellular carcinoma(HCC) is highly heterogeneous in nature and has been one of the most common cancer types worldwide. To ensure repeatability of identified gene expression patterns and comprehensively annotate the transcriptomes of HCC, we carefully curated 15 public HCC expression datasets that cover around 4000 clinical samples and developed the database HCCDB to serve as a one-stop online resource for exploring HCC gene expression with userfriendly interfaces. The global differential gene expression landscape of HCC was established by analyzing the consistently differentially expressed genes across multiple datasets. Moreover, a 4 D metric was proposed to fully characterize the expression pattern of each gene by integrating data from The Cancer Genome Atlas(TCGA) and Genotype-Tissue Expression(GTEx). To facilitate a comprehensive understanding of gene expression patterns in HCC, HCCDB also provides links to third-party databases on drug, proteomics, and literatures, and graphically displays the resultsfrom computational analyses, including differential expression analysis, tissue-specific and tumorspecific expression analysis, survival analysis, and co-expression analysis. HCCDB is freely accessible at http://gffzzbcb113a830484641hfncbqpxnuonk6wwc.ffgz.tsg.suse.edu.cn/database/hccdb. | Qiuyu Lian Shicheng Wang Guchao Zhang Dongfang Wang Guijuan Luo Jing Tang Lei Chen Jin Gu | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 5 |
| 2 | Systemic Vasculitis:An Important and Underestimated Cause of Malignant Hypertension显示文摘Objectives:Malignant hypertension(MHT)is defi ned as severe hypertension accompanied by ischemic failure of one or more organs.The aims of this study were to evaluate the current clinical and etiologic profi les of MHT.Methods:As a retrospective study,we selected all patients admitted to our center from January 2013 to December 2016.Seventy patients with MHT were included.Results:The average age of the patients was 40 years,and more than half of the patients were male(78.57%).There were 24 patients with essential hypertension,accounting for 34.29%of the patients,and 46 with secondary hypertension,accounting for 65.71%of the patients.For secondary MHT,systemic vasculitis(25.57%)was the most common cause,followed by severe obstructive sleep apnea syndrome(15.71%),primary renal parenchymal hypertension(11.43%),primary aldosteronism(7.14%),and Cushing syndrome(1.43%)and nutcracker phenomenon(1.43%).Twenty patients with systemic vasculitis were characterized by severe hypertension accompanied by damage to two or more target organs of differing severity.The levels of white blood cells,hypersensitive C-reactive protein,serum creatinine,and 24-hour urinary protein were above their normal range.Conclusion:Systemic vasculitis may be one of the main causes of MHT,and has been underestimated in the past.In future clinical work,clinicians need to pay more attention to patients with systemic vasculitis. | Qing Zhu Shasha Liu Mulalibieke Heizhati Xiaoguang Yao Menghui Wang Qin Luo Lei Wang Delian Zhang Guijuan Chang Nanfang Li | 2019 | Cardiovascular Innovations and Applications2019，，B07： | 2 |
| 4 | A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection显示文摘HepatoBiliary Surg Nutr 2021;10(4):464-475|http://gffzz4205af39ffde493ehfncbqpxnuonk6wwc.ffgz.tsg.suse.edu.cn/10.21037/hbsn.2020.01.07 Original Article A combined Cox and logistic model provides accurate predictive performance in estimation of time-dependent probabilities for recurrence of intrahepatic cholangiocarcinoma after resection Seogsong Jeong1,2#,Guijuan Luo2,3#,Qiang Gao4#,Jing Chen2,3#,Xiaolong Liu5,Liangqing Dong4,Yongjie Zhang6,Feng Shen7,Qingbao Cheng8,Chengjun Sui9,Jingfeng Liu5,Hongyang Wang2,3,Qiang Xia1,Lei Chen2,101Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China;2International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai,China;3National Center for Liver Cancer,Shanghai,China;4Department of Liver Surgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital,and Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education),Fudan University,Shanghai,China;5Mengchao Hepatobiliary Hospital,Fujian Medical University,Fuzhou,China;6Biliary Tract Department II,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;7Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;8Biliary Tract Department I,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;9Department of Special Medical Care&Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai,China;10Shanghai Cancer Center,Shanghai Medical College,Fudan University;Shanghai,China Contributions:(I)Conception and design:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(II)Administrative support:All authors;(III)Provision of study materials or patients:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(IV)Collection and assembly of data:All authors;(V)Data analysis and interpretation:S Jeong,G Luo,Q Gao,J Chen,J Liu,H Wang,Q Xia,L Chen;(VI)Manuscript writing:All authors;(VII)Final approval of manuscript:All authors.#These authors contributed equally to this work.Correspondence to:Lei Chen;Hongyang Wang.International Cooperation Laboratory on Signal Transduction,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,225 Changhai Road,Shanghai 200438,China.Email:chenlei@smmu.edu.cn;hywangk@vip.sina.com;Qiang Xia.Department of Liver Surgery,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,160 Pujian Road,Shanghai 200127,China.Email:xiaqiang@shsmu.edu.cn. | Seogsong Jeong Guijuan Luo Qiang Gao Jing Chen Xiaolong Liu Liangqing Dong Yongjie Zhang Feng Shen Qingbao Cheng Chengjun Sui Jingfeng Liu Hongyang Wang Qiang Xia Lei Chen | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 0 |
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