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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet . 2005 (9454)2005，，： | 2 |
| 3 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 4 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 5 | Ablation of Ca~(2+)channel beta3subunit leads to enhanced N-methyl-D-aspartate receptor dependent long term potentiation and improved long term memory显示文摘 | Jeon D Song 1 Guido W | 2008 | J Biol Chem2008，283，12： | 1 |
| 6 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | 2005 (9454)2005，，9454： | 1 |
| 7 | Drilling Straight Down 显示文摘 | Guido B Pete L Mike W | 2004 | Oilfield Review2004，16，3： | 1 |
| 8 | Health effects of quer- cetin: from antioxidant to nutraceutical 显示文摘 | AGNES W B GUIDO R H ALAT B | 2008 | European Jour- nal of Pharmacology2008，585，23： | 1 |
| 9 | The 10 × ' 20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020显示文摘 | Gilbert D N Guidos R J Boucher H W | 2010 | Clin Infect Dis2010，50，8： | 1 |
| 10 | Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial显示文摘 | Harry LA Janssen Monika van Zonneveld Hakan Senturk Stefan Zeuzem Ulus S Akarca Yilmaz Cakaloglu Christopher Simon Thomas MK So Guido Gerken Robert A de Man Hubert GM Niesters Pieter Zondervan Bettina Hansen Solko W Schalm | 2005 | The Lancet2005，，9454： | 1 |
| 11 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 1 |
| 12 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 13 | TDP2, TOP2, and SUMO: what is ZATT about?显示文摘 | Guido Zagnoli-Vieiral Keith W Caldecott | 2017 | Cell Research2017，27，12： | 1 |
| 14 | Reversab le neurological def- icits in chronic alcohol abuser: a case report of wernicke's en ceph- alopathy显示文摘 | Guido M E Brady W Debehnke D | 1994 | Am J Emerg Med1994，12，2： | 1 |
| 15 | Finding the most vital node of a shortest path显示文摘 | ENRICO N GUIDO P PETER W | 2003 | Theoretical Computer Science2003，，1： | 1 |
| 16 | Differences in white matter fiber tract development present from 6 to 24months in infants with autism显示文摘 | JASON J W HONGBIN G GUIDO G | 2012 | Am J Psych2012，169，6： | 1 |
| 17 | Nitric oxide synthase distribution in the cat superior collieulus and co-localization with choline acetyltransferase 显示文摘 | Scheiner C Arceneaux R Guido W | 2000 | J Chem Neuroanat2000，18，： | 1 |
| 18 | Feasibility study and control values of transient elastography in healthy children显示文摘 | Guido E Caroline G Daniel W | 2011 | Eur J Pediatr2011，171，2： | 1 |
| 19 | Feasibility study and control values of transient elastography in healthy children显示文摘 | Guido Engelmann Caroline Gebhardt Daniel Wenning Elke Wühl Georg F Hoffmann Buket Selmi Juergen Grulich-Henn Jens Peter Schenk Ulrike Teufel | 2012 | European Journal of Pediatrics2012，，2： | 1 |
| 20 | Pentaerythritol tetrakis (4 - iodo - 2,3,5,6 - tetrafluorophenyl) ether: a tecton for the self - assembly of double strand 1 D infinite chains 显示文摘 | Guido E Metrangolo P Panzer | 2005 | J Fluorine Chem2005，126，： | 1 |
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