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| 1 | Fatigue crack propagation behavior of Ni-based superalloys after overloading at elevated temperatures显示文摘The fatigue crack propagation behavior of three superalloys subjected to a single overloading at elevated temperatures was investigated. The fatigue crack propagation rate FCPR versus stress intensity factor range data da/dN—ΔK were calculated using the two-point secant method. It was found that the crack growth rates of the investigated materials were retarded after overloading with an overload ratio R OL=1.6. The size of the plastic zone in the front of the crack tip and its relation to loading level were discussed. The overload retardation effects are attributed to crack closure. The fatigue damage in the plastic zone can also be a factor to explain the overload retardation. | Xinyue Huang Liang Wang Yunming Hu Guangping Guo David Salmon Ying Li Wenxia Zhao | 2016 | Progress in Natural Science:Materials International2016，26，2： | 4 |
| 2 | Risk factors of acute myocardial infarction following primary percutaneous coronary intervention among elderly patients显示文摘背景和客观大使随机化的控制试用证明了然而,有平淡的使用 ofdrug-eluting stents 的经皮的冠的干预(一种总线标准)安全、有效比经历一种总线标准的 75 年老的病人在为主要不利心脏的事件的增加的风险,以便病人通常从这试用被排除。现在的学习的目的是与尖锐的圣举起在老病人估计早临床的结果和风险因素心肌的梗塞(STEMI ) 追随者主要一种总线标准。我们与尖锐 STEMI 在我们的冠的照顾单位在比 60 年老的 136 个病人在 stenting 以后分析了结果的方法,和病人进一步在 2 个年龄组被分类:patients75 年并且 < 75 年。尽管更老的组比那些有不利基线特征和更低的最后的 TIMI 流动的更高的流行,结果更年轻,程序的成功没有二个组之间的差别。为老组的主要不利临床的事件(向) 有点更高与正在作比较在起来的 12 月的列在后面更年轻。结论我们的学习与心肌的梗塞有的尖锐的圣举起在老病人建议那 drug-eluting stent 培植尽管有有更多的严重基线的高起始的程序的成功率冒险特征,并且弄短时间形式症状发作到 PC1 并且改进最后的 TIMI 流动策略可以减少在跟随一种总线标准的老病人之中的向。 | Fangming Guo Xiaohuan Wang Guangping Li Xin Chen Yuguang Jin | 2009 | Journal of Geriatric Cardiology2009，6，2： | 2 |
| 3 | Novel Cinobufagin Oxime Ether Derivatives as Potential Na+/K+-ATPase Inhibitors: Synthesis, Biological Screening and Molecular Docking显示文摘 | LIANG Guangping CHUNG Tseyu GUO Jinhua ZHANG Rongrong XU Wei TZEN Jason T.C JIANG Renwang | 2017 | Chemical Research in Chinese Universities2017，33，3： | 1 |
| 4 | Research on Causality Relationship of Low-Carbon Development and Industrial Structure显示文摘 | Liu Chunmei Duan Maosheng Zhang Xiliang Zhou Jieting Zhang Tianhou Yang Guang Ou Xunmin Wang Enchuang Dai Chunyan Guo Shiyi Hu Guangping Zhou Lingling Qi Tianyu | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 5 | Primary percutaneous coronary intervention on older patients with acute ST-segment elevation myocardial infarction: analysis of its risk factors显示文摘Objective: The aim of the present study was to assess the early clinical outcome and risk factors in old patients with acute ST elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (PCI). Methods: A total of 136 patients older than 60 years with STEMI who received successful PCI were included in this study. The patients were classified in 2 age groups: patients ≥75 years and <75 years of age. The extent of coronary artery lesions was measured by quantitative coronary artery angiography (QCA). Subjects were tracked for subsequent cardiovascular events: cardiac death, myocardial infarction, heart failure, percutaneous coronary intervention, coronary artery bypass and stroke. Results: Though the older group had a higher prevalence of adverse baseline characteristics and lower final TIMI flow than patients<75y (P<0.05), the procedural success did not make difference between the two groups. In 12 months follow-up of 136 study participants, there occurred 39 CV events : cardiac death (five patients), heart failure (nineteen patients), and stroke (six patients). Three patients received coronary bypass grafts and six patients underwent PCI. Heart failure and overall cardiovascular event rates were higher in older patients compared with those in patients<75y. The main adverse clinical events (MACE) for the old group were a little higher comparing with the younger in 12-month follow-up (P=0.029 6 and P=0.043 4). Multivariate cox analysis identified that a diagnosis of diabetes (HR 2.495, 95%CI 1.224 to 5.083, P= 0.011 8) and time from symptom(HR 1.450, 95%CI 1.143 to 1.841, P= 0.008 2) to PCI as independent predictors of CV events after adjustment of all entered baseline variables. Conclusion: Our study suggests that drug-eluting stent implantation in older patients with acute ST elevation myocardial infarction has high initial procedural success rates despite having more severe baseline risk characteristics, and to shorten the time from symptom onset to PCI may decrease cardiovascular events in old patients following PCI. | Guo Fangming Wang Xiaohuan Li Guangping Chen Xin Fan Juexin | 2010 | Journal of Medical Colleges of PLA(China)2010，25，1： | 1 |
| 6 | Modeling and characterizing the typical under-ice acoustic channel for the Arctic显示文摘The properties of arctic underwater acoustic channel were researched using BurkeTwersky(BT) model and ray theory.In the BT model,sea ice ridge is assumed as a set of semi-elliptical cylinder randomly distributed on a stress-free surface.By approximation of low frequency and high frequency of the BT model,the reflection coefficients were calculated at different frequencies.On the basis of ray theory,the acoustic field was calculated and the properties of underwater acoustic channel was analyzed.Compared to underwater acoustic channel properties when the boundary is air,the results show that under the ice surface some sound rays disappear during transmission,because the ice surface reflection coefficients is less than absolute soft surface.Especially,the higher the frequency,the higher the under-ice transmission loss.As a result,under-ice condition is unfavourable for acoustic signals to travel far.Besides,as to the channel structure,the reflection coefficient of ice layer is smaller,the channel multi-path structure is not significant compared to water-air interface without ice.The research results are valuable for our understanding of hydroacoustic channel and the prediction of the sonar system working in the polar region. | ZHU Guangping YIN Jingwei ZHOU Huanling CHEN Wenjian HU Siwei GUO Longxiang | 2019 | Chinese Journal of Acoustics2019，38，2： | 1 |
| 7 | Static Expansion Vacuum Standard with Extended Low Pressure Range 显示文摘 | Li Detian Zhao Guangping Guo Meiru | 2009 | MAPAN-Joumal of Metrology Society of India2009，24，2： | 1 |
| 8 | Dynamic changes of nutrient content in herbaceous peony seed显示文摘Herbaceous peony is a promising oilseed crop.‘Hangshao’and‘Fenghuang Niepan’are two cultivars with high yield and oil content In this study,seed reserved nutrient of these two genotypes were investigated during seed development process.Results showed that‘Hangshao’and‘Fenghuang Niepan’matured approximately 85 d after flowering(DAF).The development p rocess could be divided into four stages:seed formation and enlargement stage(S1),seed inclusion and enrichment stage(S2),crude fat rapid accumulation stage(S3)and dehydration and color transition stage(S4).During this process,100-seed fresh weight(HFW)and 100-seed dry weight(HDW)increased,whereas water content(WC)decreased.HFW,HDW and WC for‘Hangshao’seed at 85 DAF were28.56 g,20.78 g and 37.50%respectively,whereas those for‘Fenghuang Niepan’seed were 27.2 g,19.78 g,and30.85%respectively.In terms of the primary metabolites measuring,soluble protein content was consistently low(only 2.24%-3.15%),while starch content was relatively high(5.60%-24.81%).They displayed a trend of gradual increasing in early stage,followed by rapid decline.Crude fat tended to accumulate continuously with a linear upward trend starting at 40 DAF,and its maximum level was reached at 85 DAF(27.57%for‘Hangshao’and29.57%for‘Fenghuang Niepan’).For the secondary metabolites determination,total phenols content was relatively steady,maintaining at 107.7-129.9 mg/g for both cultivars,while total flavonoids content varied within25.33-65.33 mg/g for‘Hangshao’and 24.33-52.37 mg/g for Tenghuang Niepan’.The maximum level for both cultivars occurred at 55 DAF.Furthermore,crude fat content was found to be highly correlated with WC by correlation analysis and linear regression model definition(P≤0.01 and r=0.954).Thus,WC was recommended for evaluating crude fat in peony seed.These findings could provide scientific reference for high-yielding production practice for oleaginous peony plant. | Qimo Qi Yu Li Fanzhi Meng Guangping Xing Jilei Zhou Xianfeng Guo | 2020 | Oil Crop Science2020，5，2： | 0 |
| 9 | Layer-by-layer enriching active Ni-N_(3)C sites in nickel-nitrogen-carbon electrocatalysts for enhanced CO_(2)-to-CO reduction显示文摘Transition metal and nitrogen co-doped carbons(M-N-C)have proven to be promising catalysts for CO_(2)electroreduction into co because of the high activity and selectivity.Effective enrichment of the active transition metal coordinated nitrogen sites is desirable but is challenging for a practical volumetric productivity.Herein,we report four kinds of model electrocatalysts to unveil this issue,which include the NC structures with surface N-functionalities,Ni-N-CI with one layer of surface Ni-NsC sites,NC@Ni-N-CI with surface N-functionalities and underneath Ni-N3C sites as well as Ni-N-C_II with doubled surface Ni-NsC sites.The X-ray absorption spectroscopy indicates the coordination configuration of Ni-NsC.For NC catalysts,when N-doping level increased from 3.5 at%to 8.4 at%,the CO partial current density increased from below 0.1 mA/cm^(2)to 3 mA/cm^(2).Introducing one layer of Ni-N_(3)C onto the NC structures leads to a 54 times higher CO partial current density than that of NC,in the meantime the FE_(CO) is 66 times higher.Furthermore,doubling the density of surface Ni-N_(3)C sites by a layer-by-layer method doubles the CO partial current density Gco,indicating its potential to achieve a high density of active coordinated sites and current densities. | Yongqi Ren Ruopeng Chang Xu Hua Junjie Guo Guangping Hao Anhui Lu | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 10 | Regulation of osteoblast functions on titanium surfaces with different micro/nanotopographies and compositions显示文摘Surface modification of medical implants is considered as an effective method to improve cellular behaviors and the integration of tissues with materials. Titanium(Ti)-based materials with four different micro/nano-structures and compositions were prepared by acid etching, electrochemical anodization and alkali-heat treatment. The surface morphologies and compositions of the different surface-modified Ti materials were characterized by field-emission scanning electron microscopy(FE-SEM),atomic force microscopy(AFM) and X-ray diffraction(XRD). The effects of the micro/nano structured and compositions of the surfaces on cellular responses were investigated in vitro by observing the morphology, adhesion, proliferation and osteogenic differentiation of osteoblasts. To further investigate the underlying mechanisms, an RT-PCR assay was performed to analyze the expression levels of cell adhesion-related genes. Our results indicated that the nanosized structure and anatase composition could promote the adhesion and proliferation of MC3T3-E1 pre-osteoblast, as well as alkaline phosphatase activity and extracellular matrix mineralization via the integrin-FAK signaling pathway. Taken together, our innovation presented in this work demonstrated that the surface nano-structure design and composition of biomedical implants can be modified of for future orthopaedic applications. | HE Peng WANG XiaoLan NING ChengYun LIU XiaoWei LI Mei XU HaiDong GUO GuoDong MAO GuangPing LIU Gang XU Bin ZHANG Yu ZHAO JianNing | 2019 | Science China(Technological Sciences)2019，62，4： | 0 |
| 11 | Elucidation of the melitidin biosynthesis pathway in pummelo显示文摘Specialized plant metabolism is a rich resource of compounds for drug discovery.The acylated flavonoid glycoside melitidin is being developed as an anti-cholesterol statin drug candidate,but its biosynthetic route in plants has not yet been fully characterized.Here,we describe the gene discovery and functional characterization of a new flavonoid gene cluster(UDP-glucuronosyltransferases(Cg UGTs),1,2rhamnosyltransferase(Cg1,2Rha T),acyltransferases(Cg ATs))that is responsible for melitidin biosynthesis in pummelo(Citrus grandis(L.)Osbeck).Population variation analysis indicated that the tailoring of acyltransferases,specific for bitter substrates,mainly determine the natural abundance of melitidin.Moreover,3-hydroxy-3-methylglutaryl-Co A reductase enzyme inhibition assays showed that the product from this metabolic gene cluster,melitidin,may be an effective anti-cholesterol statin drug candidate.Co-expression of these clustered genes in Nicotiana benthamiana resulted in the formation of melitidin,demonstrating the potential for metabolic engineering of melitidin in a heterologous plant system.This study establishes a biosynthetic pathway for melitidin,which provides genetic resources for the breeding and genetic improvement of pummelo aimed at fortifying the content of biologically active metabolites. | Shuangqian Shen Shouchuang Wang Chenkun Yang Chao Wang Qianqian Zhou Shen Zhou Ran Zhang Yufei Li Zixuan Wang Liupan Dai Wenjv Peng Yingchen Hao Hao Guo Guangping Cao Xianqing Liu Fan Yao Qiang Xu Alisdair RFernie Jie Luo | 2023 | Journal of Integrative Plant Biology2023，65，11： | 0 |
| 12 | Synthesis and Cytotoxic Activities of Spin-labeled Derivatives of Cinobufagin显示文摘 | GUO Jinhua TAN Bei YE Qingmei LIANG Guangping YI Min JIANG Renwang | 2017 | Chemical Research in Chinese Universities2017，33，4： | 0 |
| 13 | Antibiotic Sensitivity Test and Detection of Sulfonamide Resistance Gene Sul2 in Escherichia coli Isolates from Swine显示文摘[Objective] This study aimed to analyze antibiotic sensitivity and detect sulfonamide resistance gene Sul2 in 17 Escherichia coli isolates from swine.[Method]The antibiotic sensitivity of 17 E.coli isolates from swine was analyzed with Kirby-Bauer disk diffusion method.Sulfonamide resistance gene Sul2 was detected by PCR amplification with the extracted genomic DNA as a template.[Result] The 17 swine-derived E.coli isolates from different regions were resistant to various antibiotics and exhibited different multi-antibiotic resistance phenotypes,including nine isolates resistant to sulfamethoxazole,seven isolates resistant to oxacillin,ten isolates resistant to cefazolin and eight isolates resistant to erythromycin.Sulfonamide resistance gene Sul2 was successfully amplified from genomic DNA of E.coli isolates.The PCR results were basically consistent with antibiotic resistance phenotypes of these strains.[Conclusion] Sul2 gene was widespread in swine-derived E.coli,which was closely associated with sulfonamide resistance phenotypes of E.coli. | Yanying ZHANG Fang XIANG Rui GUO Zhaoxing ZHANG Qiumei SHI Yuqin LIU Cairan YANG Zongze YANG Guangping GAO Guisheng GAO Zhi PENG Xun SUO | 2016 | Agricultural Biotechnology2016，5，2： | 0 |
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