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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Molecular aspects of Cu,Fe and Zn homeostasis in plants显示文摘 | GROTZ N GUERINOT M L | 2006 | Biochim Biophys Acta2006，1763，： | 1 |
| 3 | IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | Vert G Grotz N Dedaldechamp F | 2002 | Plant Cell2002，14，： | 1 |
| 4 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency 显示文摘 | Grotz N Fox T Connolly E | 1998 | Proc Natl Acad Sci USA1998，95，12： | 1 |
| 5 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | Grotz N Fox T Connolly E | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 6 | IRT1,an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | Vert G Grotz N Dédaldéchamp F | 2002 | Plant Cell2002，14，： | 1 |
| 7 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | GROTZ N FOX T CONNOLLY E et ol | 1998 | Proceedings of the National Academy of Science of the United States of America1998，95，12： | 1 |
| 8 | IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | Vert G Grotz N Dedaldechamp F | 2002 | Plant Cell2002，14，： | 1 |
| 9 | IRT1,an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | Vert G Grotz N Dédaldéchamp F | 2002 | The Plant Cell2002，14，： | 1 |
| 10 | IRT1 an Arabidopsis transporter essential for iron uptake from the soil and for plant growth 显示文摘 | Vert G Grotz N D6daldchamp F | 2002 | Plant Cell2002，14，： | 1 |
| 11 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | GROTZ N FOX T CONNOLLY E L PARK W GUERINOT M L EIDE D J | 1998 | Proceedings of the National Academy of Sciences USA1998，95，： | 1 |
| 12 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc de fieiency显示文摘 | GROTZ N FOX T CONNOLLY E L | 1998 | Proceedings of the National Academy of Sciences USA1998，95，12： | 1 |
| 13 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | GROTZ N FOX T CONNOLLY E PARK W GUERINOT M L DAVID E | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，： | 1 |
| 14 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | GROTZ N FOX T CONNOLLY E | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 15 | IRT1, an arabi- dopsis transporter essential for iron uptake from the soil and for plant growth 显示文摘 | Vert G Grotz N Dedaldecbamp F | 2002 | The Plant Cell2002，14，12： | 1 |
| 16 | IRT1,an Arabidopsis transporter essential for iron uptake from the soil and plant growth显示文摘 | VERT G GROTZ N DéDALDéCHAMP F | 2002 | Plant Cell2002，14，： | 1 |
| 17 | IRTI, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth 显示文摘 | Vert G Grotz N Dedaldechamp F | 2002 | Plant Cell2002，14，6： | 1 |
| 18 | Discriminat value of psychological distress, symptom profiles, and segment colonic dysfunction in outpatients with severe idiopathic constipation显示文摘 | Grotz R L Pemberton J H Talley N J | 1994 | Gut1994，35，6： | 1 |
| 19 | IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth显示文摘 | VERT G GROTZ N DEDALDECHAMP F | 2002 | Plant Cell2002，14，： | 1 |
| 20 | Martinez-arias onthe nature of V and Mg ions in V, Mg-containing AlPO4-5 catalysts 显示文摘 | Blasco T Concepción P Grotz P López Nieto J M A | 2000 | Journal ofmolecular catalysis A: chemical2000，162，： | 1 |
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