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123篇 您的检索式：作者名="Gribben"

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	题名	作者	年代	出处	被引量
1	B7-1与B7-2对调节人IL-2基因的转录因子NF-κB和AP-1的相同作用显示文摘为了解B7共刺激对细胞因子 ,特别是对IL 2mRNA及转录因子NF κB和AP 1的影响 ,探讨B7介导的IL 2调节的分子机制 ,在异基因混合淋巴细胞反应 (MLR)体系中分别或联合加入抗B7 1、抗B7 2单克隆抗体和CTLA 4Ig以阻断B7/CD2 8信号传导 ,通过竞争性PCR定量检测其对IL 2和IL 4mRNA的影响 ,并初步测定IFN γmRNA的改变 ,同时用转染MHCⅡ类分子及联合转染等量B7 1或B7 2的NIH3T3转基因细胞tDR7,tDR7/B7 1和tDR7/B7 2刺激CD2 8+ T细胞 ,通过DNA 蛋白结合实验观察B7对IL 2转录因子NF κB和AP 1的影响。结果表明 :抗B7 2单抗和CTLA 4Ig可明显抑制B7介导的IL 2和IL 4mRNA合成 ,而抗B7 1单抗仅有轻度抑制作用 ,2种或 3种抗体联合应用时抑制作用相加。MLR 1 - 6小时 ,单独tDR7即可诱导NF κB的表达 ,联合转染B7早期对其结合活力无明显影响 ,6小时后tDR7诱导作用减弱 ,B7却可显著延长tDR7的诱导作用至 72小时。tDR7早期同样可诱导AP 1的表达 ,联合转染B7分子在 2 4小时内对其有一定的抑制作用 ,而在反应后期可延长tDR7对AP 1的上调作用 ,B7 1与B7 2间作用未见明显不同。结论 :B7通过减少IL 2mRNA降解和影响基因转录而上调IL 2分泌 ,并可同时影响多种细胞因子分泌 ;在转录水平B7 1与B7 2作用未见明显不同。	克晓燕 John Gribben 王晶王德炳	2002	中国实验血液学杂志2002，10，6：	5
2	Activated Pancreatic Stellate Cells Sequester CD8+ T-Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma显示文摘	Abasi Ene-Obong Andrew J. Clear Jennifer Watt Jun Wang Rewas Fatah John C. Riches John F. Marshall Joanne Chin-Aleong Claude Chelala John G. Gribben Alan G. Ramsa Hemant M. Kocher	2013	Gastroenterology2013，，：	4
3	Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma显示文摘	Gribben JG Freedman AS Neuberg D	1991	N Engl Med1991，325，：	1
4	Phase Ⅱ study of single-agent bortezomib for the treatment of pa tients with fludarabine-refractory B-cell chronic lyre phocytic leukemia显示文摘	FADERL S RAI K GRIBBEN J	2006	Cancer2006，107，：	1
5	How I treat indolent lymphoma显示文摘	Gribben JG	2007	Blood2007，109，11：	1
6	Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK 显示文摘	Gribben J Hubbard RB Le-Jeune I	2006	Thorax2006，61，11：	1
7	Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparticles prior to high-dose therapy for patients with non-Hodgkin 's lymphoma显示文摘	Webb IJ Friedberg nW Gribben JG	2002	Biol Blood Marrow Transplant2002，8，8：	1
8	Activated Pancreatic Stellate Cells Sequester CD8 + T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma显示文摘	Abasi Ene–Obong Andrew J. Clear Jennifer Watt Jun Wang Rewas Fatah John C. Riches John F. Marshall Joanne Chin–Aleong Claude Chelala John G. Gribben Alan G. Ramsay Hemant M. Kocher	2013	Gastroenterology2013，，5：	1
9	Numerical study of shock-reflection hysteresis in an under expanded jet显示文摘	Gribben B J Badcock K J	2000	AIAA jour-nal2000，38，2：	1
10	A grid deformation technique for unsteady flow computations 显示文摘	Dubuc L Cantariti F Woodgate M Gribben B Bad- cock K J Richards B E	2000	International Journal for Numerical Methods in Fluids2000，32，：	1
11	select high - risk genetic features predict earlier pro- gression following chemoimmunotherapy with fludarabine and rituximab in chronic lympho- cytic leukemia: justification for risk -adapted therapy显示文摘	Byrd JC Gribben JG Peterson	2006	J Clin Onco12006，24，3：	1
12	Larval development of the New Zealand geoduck Panopea zelandica ( Bivalvia: Hiatellidae) 显示文摘	Gribben P E Hay B E	2003	New Zealand Journal of Marine and Freshwater Research2003，37，：	1
13	Pivotal role of the B7: CD28 pathway in transplantation tolerance and tumor immunity显示文摘	Guinan EC Gribben JG Boussiotis VA Freeman GJ Nadler LM	1994	Blood1994，84，10：	1
14	B-cell surface antigen 137 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2显示文摘	Gimmi CD Freeman GJ Gribben JG Sugita K Freedman AS Morimoto C	1991	Proc Natl Acad Sci USA1991，88，15：	1
15	All advanced stage NonHodgkin's lmphomas with a polymerase chain reaction amplifiable breakpoint of bcl-2 have residual ceils containing the bcl-2 rearrangment at evaluation and after treatment 显示文摘	Gribben JG Freedman AS Woo SD	1991	Blood1991，78，12：	1
16	Real-time polymerase chain reaction estimation of bone marrow tumor burden using clonal immunoglobulin heavy chain gene and bcl -1/JH rearrangements in mantle cell lymphoma显示文摘	Niels S. Andersen John W. Donovan Amy Zuckerman Lone Pedersen Christian Geisler John G. Gribben	2002	Experimental Hematology2002，，7：	1
17	Insulin-like growth factor bind- ing protein-3 inhibits migration of endometrial cancer cells 显示文摘	Gribben L Baxter RC Marsh DJ	2012	Can- cer Lett2012，317，1：	1
18	Immune Reconstitution in Chronic Lymphocytic Leukemia显示文摘	John C. Riches Alan G. Ramsay John G. Gribben	2012	Current Hematologic Malignancy Reports2012，，1：	1
19	Select high-risk genetic features predict earlier progression following chemoimmuno-therapy with fludarabine and rituximab in chronic lymphocytic leukemia; justification for risk-adapted therapy显示文摘	Byrd JC Gribben JG Peterson BL	2006	J Clin Oncol2006，24，3：	1
20	CTLA-4 mediates antigen - specific apoptosis of human T cells 显示文摘	Gribben JG Freeman GJ Boussiotis VA	1995	Proc Natl Acad Sci USA1995，92，：	1

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