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| 1 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 2 | Bcl-2 and GDNF delivered by HSV-mediated gene transfer act additively to protect dopaminergic neurons from 6-OHDA-induceddegeneration显示文摘 | Mata M Goss J | 2001 | Exp Neurol2001，169，： | 1 |
| 3 | Threat Perception in Product Harm Crises:Do Older Consumers Feel More Vulnerable?显示文摘 | Silvera D H Meyer T Laufer D Goss R J Arsena A R | 2010 | Advances in Consumer Research2010，37，： | 1 |
| 4 | Orthotopic liver transplantation for primary sclerosing chlolangitis:a 12-year single experience显示文摘 | Goss J A Shackleton C R Farmer D G | 1997 | Ann Surg1997，225，： | 1 |
| 5 | Phosphorylation states of translational initiation factors affect mRNA cap binding in wheat显示文摘 | Khan M A Goss D J | 2004 | Biochemistry2004，43，28： | 1 |
| 6 | Addressing the difficulties in using inductive methods to evaluating human body composition显示文摘 | Peyton A J Mackin R Goss D | 2003 | Biometrie Humaine at Anthropologie2003，21，： | 1 |
| 7 | Inhibition of carbohydrate processing:A new class of anticancer agent显示文摘 | Goss P E Baker M A Carver J P | 1995 | Clin Cancer Res1995，1，9： | 1 |
| 8 | Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture显示文摘 | DAVEY J C BODWELL J E GOSSE J A | 2007 | Toxicol Sci2007，98，： | 1 |
| 9 | Seasonal changes in the response of oyster catchers Haematopus ostralegusto human disturbance 显示文摘 | STILLMAN R A GOSS - CUSTARD J D | 2002 | Journal of Avian Biology2002，33，： | 1 |
| 10 | Selected review on genetic factors in myopia显示文摘 | Hampton M J Wickham M G | 1998 | J Am Opt Assoc1998，59，11： | 1 |
| 11 | Incipient electrochemical oxidation of highly oriented pyrolytic graphite: Correlation between surface blistering and elec- trolyte anion intercalation显示文摘 | Hathcock K W Brumfield J C Goss C A | 1995 | Analytical Chemistry1995，67，13： | 1 |
| 12 | Predicting the impacts of disturbance on shore bird mortality using a behavior based model 显示文摘 | West A D Goss - Custard J D StiUman R A | 2002 | Biological Conservation2002，106，3： | 1 |
| 13 | Assembly of h/HLH/z proteins c-Myc,Max,and Madl with cognate DNA:importance of protein-protein and protein-DNA interactions显示文摘 | Hu J Banerjee A Goss DJ | 2005 | Biochemistry2005，44，11： | 1 |
| 14 | Creation of charge carriers in nonpo- lar liquids显示文摘 | Alj A Denat A Gosse J P | 1985 | IEEE Transactions on Electrical Insulation1985，9，2： | 1 |
| 15 | The saponins-polar isoprenoids with important and diverse biological activities 显示文摘 | Osboum A Goss R J Field R A | 2011 | Nat Prod Rep2011，28，7： | 1 |
| 16 | Carrying ca pacity in overwintering migratory birds显示文摘 | GOSS C J D STILLMAN R A WEST A D | 2002 | Biological Conser- vation2002，105，： | 1 |
| 17 | Development,physiology and biochemistry of corn and wheat pollen显示文摘 | Goss J A | 1968 | The Botanical Review1968，34，3： | 1 |
| 18 | arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture显示文摘 | DAVEY J C BODWELL J E GOSSE J A | 2007 | Toxicol Sci2007，98，1： | 1 |
| 19 | Contamination in Ontario farmstead domestic wells and its association with agriculture: results from drinking water wells显示文摘 | GOSS M J BARRY D A J RUDOLPH D L | 1998 | Joumal of Contaminant Hydrology1998，32，34： | 1 |
| 20 | The mechanism of antler cast- ing in the fallow deer显示文摘 | Goss R J van P A Brewer P | 1992 | Exp Zool1992，264，： | 1 |
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