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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Estimation in vivo of the body and carcass chemical composition of growing lambs by real-time ultrasonography显示文摘 | SILVA S R GOMES M J MAS-DA-SILVA A | 2005 | Journal of Animal Science2005，83，： | 1 |
| 3 | Effect of the inoculation level of Lactobacillus acidophilus in probiotic cheese on the physicochemical features and sensory performance compared with commercial cheeses显示文摘 | GOMES A A BRAGA S P CRUZ A G | 2011 | Journal of Dairy Science2011，94，： | 1 |
| 4 | Reflection Z-scan technique for measurements of optical properties of surface显示文摘 | Petrov D V Gomes A S L de Arauújo C B | | 0，，： | 1 |
| 5 | Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium显示文摘 | Hou J Renigunta A Gomes A S | | 0，，： | 1 |
| 6 | Optimal inspection planning for onshore pipelines subject to external corrosion显示文摘 | Gomes W J S Beck A T Haukaas T | 2013 | Reliability Engineering & System Safety2013，118，： | 1 |
| 7 | Laser action in strongly scattering media显示文摘 | Lawandy N M Balachandran R M Gomes A S L | 1994 | Nature1994，，368： | 1 |
| 8 | Synthesis and characterization of tetrahedral and square planar bis (iminopyrrolyl) complexes of cobalt ( Ⅱ ) 显示文摘 | Carabineiro S A Silva L C Gomes P T | 2007 | Inorg Chem2007，46，： | 1 |
| 9 | An amperometric biosensor for polyphenolic compounds in red wine 显示文摘 | Gomes S A S S Nogneim J M F Rebelo M J F | 2004 | Biosensors and Bioelectronies2004，20，6： | 1 |
| 10 | Numerical modeling of an industrial aluminum melting furnace显示文摘 | Nieckele A O Naccache M F Gomes M S P | 2004 | Journal of Energy Resources Technology2004，126，1： | 1 |
| 11 | Heat stress impairs performance and induces intestinal inflammation in broiler chickens infected with Salmonella Enteritidis显示文摘 | Quinteiro Filho W M Gomes A V S Pinheiro M L | 2012 | Avian Pa-thology2012，41，5： | 1 |
| 12 | Anti-inflammatory activity of tea(Camellia sinensis) root extract显示文摘 | Chattopadhyay P Besra S E Gomes A | 2004 | Life Sciences2004，74，： | 1 |
| 13 | Modeling the size distribution of a soil aerosol produced by sandblasting显示文摘 | Gaudichet A Gomes L | 1997 | Journal of Geophysical Research1997，102，11： | 1 |
| 14 | Third-order nonlinear optical properties of bismuth-borate glasses measured by conventional and thermally managed eclipse Z scan 显示文摘 | Gomes A S L Falc o Filho E L de Araujo Cid B etal | 2007 | J Appl Phys2007，101，03： | 1 |
| 15 | Heat stress impairs performance and in- duces intestinal inflammation in broiler chickens infec- ted with Salmonella Enteritidis 显示文摘 | QU1NTEIRO-FILHO W M GOMES A V S PINHEI- RO M L | 2012 | Avian Pathology2012，41，5： | 1 |
| 16 | Mineral aerosol production by wind erosion:aerosol particle size and binding energies 显示文摘 | Gaudichet A Gomes L | 1998 | Geophysical Research Letters1998，25，7： | 1 |
| 17 | Leaf gas exchange, chlorophyll fluorescence and growth responses of Genipa americana seedlings to soil flooding显示文摘 | Mielke M S Almeida A A F Gomes F P | 2003 | Environmental and Experimental Botany2003，50，： | 1 |
| 18 | Kinet- ics and isotherms of leather dye adsorption by tannery solid waste 显示文摘 | PICCIN J S GOMES C S FERIS L A | 2012 | Chemical Engineering Journal2012，183，： | 1 |
| 19 | Challenges and technological opportunities for the oil refining industry:A brazil ian refinery case显示文摘 | Branco D A C Gomes G L Szklo A S | | 0，，6： | 1 |
| 20 | Nanofiltration process for separating Cr (III) from acid solutions: experimental and modeling analysis 显示文摘 | Gomes S Cavaco S A Quina M] et a1 | 2010 | Desalination2010，254，： | 1 |
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