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| 1 | Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications显示文摘Atherosclerosis manifests itself clinically at advanced stages when plaques undergo hemorrhage and/or rupture with superimposed thrombosis, thus abruptly stopping blood supply. Identification of markers of plaque destabilization at a pre-clinical stage is, therefore, a major goal of cardiovascular research. Promising results along this line were provided by studies investigating the lipoprotein-associated phospholipase A2(Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids. We herein review the experimental and clinical studies supporting use of Lp-PLA2 activity for predicting cardiovascular events. To his end we considered not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations and their association with incident coronary artery disease, stroke, and cardiovascular mortality. Based on these evidences the major scientific societies have included in their guidelines the measurement of Lp-PLA2 activity among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk. The results of two recently published major clinical trials with the LpPLA2 inhibitor darapladib, which seem to challenge the pathogenic role of Lp-PLA2, will also be discussed. | Giuseppe Maiolino Valeria Bisogni Giacomo Rossitto Gian Paolo Rossi | 2015 | World Journal of Cardiology2015，7，10： | 66 |
| 2 | Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model显示文摘AIM: To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA activity in vivo in a mouse model of experimental infection.METHODS: Ethanol-free red wine and green tea concentrates were administered orally as a mixture of the two beverages to H pylori infected mice, or separately to VacA-treated mice. Gastric colonization and gastric in? ammation were quantifi ed by microbiological, histopathological, and immunohistochemical analyses. RESULTS: In H pylori -infected mice, the red wine and green tea mixture significantly prevented gastritis and limited the localization of bacteria and VacA to the surface of the gastric epithelium. Similarly, both beverages significantly prevented gastric epithelium damage in VacA-treated mice; green tea, but not red wine, also altered the VacA localization in the gastric epithelium. CONCLUSION: Red wine and green tea are able to prevent H pylori -induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection. | Paolo Ruggiero Giacomo Rossi Francesco Tombola Laura Pancotto Laura Lauretti Giuseppe Del Giudice Mario Zoratti | 2007 | World Journal of Gastroenterology2007，13，3： | 6 |
| 3 | Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy显示文摘Background:Parkinson’s disease(PD)is a neurodegenerative disorder whose diagnosis is often challenging because symptoms may overlap with neurodegenerative parkinsonisms.PD is characterized by intraneuronal accumulation of abnormalα-synuclein in brainstem while neurodegenerative parkinsonisms might be associated with accumulation of eitherα-synuclein,as in the case of Multiple System Atrophy(MSA)or tau,as in the case of Corticobasal Degeneration(CBD)and Progressive Supranuclear Palsy(PSP),in other disease-specific brain regions.Definite diagnosis of all these diseases can be formulated only neuropathologically by detection and localization ofα-synuclein or tau aggregates in the brain.Compelling evidence suggests that trace-amount of these proteins can appear in peripheral tissues,including receptor neurons of the olfactory mucosa(OM).Methods:We have set and standardized the experimental conditions to extend the ultrasensitive Real Time Quaking Induced Conversion(RT-QuIC)assay for OM analysis.In particular,by using human recombinantα-synuclein as substrate of reaction,we have assessed the ability of OM collected from patients with clinical diagnoses of PD and MSA to induceα-synuclein aggregation,and compared their seeding ability to that of OM samples collected from patients with clinical diagnoses of CBD and PSP.Results:Our results showed that a significant percentage of MSA and PD samples inducedα-synuclein aggregation with high efficiency,but also few samples of patients with the clinical diagnosis of CBD and PSP caused the same effect.Notably,the final RT-QuIC aggregates obtained from MSA and PD samples owned peculiar biochemical and morphological features potentially enabling their discrimination.Conclusions:Our study provide the proof-of-concept that olfactory mucosa samples collected from patients with PD and MSA possess important seeding activities forα-synuclein.Additional studies are required for(i)estimating sensitivity and specificity of the technique and for(ii)evaluating its application for the diagnosis of PD and neurodegenerative parkinsonisms.RT-QuIC analyses of OM and cerebrospinal fluid(CSF)can be combined with the aim of increasing the overall diagnostic accuracy of these diseases,especially in the early stages. | Chiara Maria Giulia De Luca Antonio Emanuele Elia Sara Maria Portaleone Federico Angelo Cazzaniga Martina Rossi Edoardo Bistaffa Elena De Cecco Joanna Narkiewicz Giulia Salzano Olga Carletta Luigi Romito Grazia Devigili Paola Soliveri Pietro Tiraboschi Giuseppe Legname Fabrizio Tagliavini Roberto Eleopra Giorgio Giaccone Fabio Moda | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 4 | Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis显示文摘 | Federica Zoratto Luigi Rossi Monica Verrico Anselmo Papa Enrico Basso Angelo Zullo Luigi Tomao Adriana Romiti Giuseppe Lo Russo Silverio Tomao | 2014 | Tumor Biology2014，，7： | 3 |
| 5 | Enhanced characterization of solid solitary pulmonary nodules with Bayesian analysis-based computer-aided diagnosis显示文摘The aim of this study was to prospectively assess the accuracy gain of Bayesian analysis-based computeraided diagnosis(CAD) vs human judgment alone in characterizing solitary pulmonary nodules(SPNs) at computed tomography(CT). The study included 100 randomly selected SPNs with a definitive diagnosis. Nodule features at first and follow-up CT scans as well as clinical data were evaluated individually on a 1 to 5 points risk chart by 7 radiologists, firstly blinded then aware of Bayesian Inference Malignancy Calculator(BIMC) model predictions. Raters' predictions were evaluated by means of receiver operating characteristic(ROC) curve analysis and decision analysis. Overall ROC area under the curve was 0.758 before and 0.803 after the disclosure of CAD predictions(P = 0.003). A net gain in diagnostic accuracy was found in 6 out of 7 readers. Mean risk class of benign nodules dropped from 2.48 to 2.29, while mean risk class of malignancies rose from 3.66 to 3.92. Awareness of CAD predictions also determined a significant drop on mean indeterminate SPNs(15 vs 23.86 SPNs) and raised the mean number of correct and confident diagnoses(mean 39.57 vs 25.71 SPNs). This study provides evidence supporting the integration of the Bayesian analysis-based BIMC model in SPN characterization. | Simone Perandini Gian Alberto Soardi Massimiliano Motton Raffaele Augelli Chiara Dallaserra Gino Puntel Arianna Rossi Giuseppe Sala Manuel Signorini Laura Spezia Federico Zamboni Stefania Montemezzi | 2016 | World Journal of Radiology2016，8，8： | 3 |
| 6 | Familial colorectal cancer screening: When and what to do?显示文摘Colorectal cancer(CRC) is the third leading cause of death worldwide and represents a clinical challenge.Family members of patients affected by CRC have an increased risk of CRC development.In these individuals,screening is strongly recommended and should be started earlier than in the population with average risk,in order to detect neoplastic precursors,such as adenoma,advanced adenoma,and nonpolypoid adenomatous lesions of the colon.Fecal occult blood test(FOBT) is a non invasive,widespread screening method that can reduce CRC-related mortality.Sigmoidoscopy,alone or in addition to FOBT,represents another screening strategy that reduces CRC mortality.Colonoscopy is the best choice for screening highrisk populations,as it allows simultaneous detection and removal of preneoplastic lesions.The choice of test depends on local health policy and varies among countries. | Giovanna Del Vecchio Blanco Omero Alessandro Paoluzi Pierpaolo Sileri Piero Rossi Giuseppe Sica Francesco Pallone | 2015 | World Journal of Gastroenterology2015，21，26： | 3 |
| 7 | Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery显示文摘Since the 19th century,appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors.This approach can be applied to any surgery for gastrointestinal cancer.During surgery for colon and rectal cancer,an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease.The adequate number of lymph nodes to be removed is standardized and reported by several guidelines.It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients.Our review focuses on the concept of“complete mesenteric excision(CME)with central vascular ligation(CVL),”a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years.The aim of this study was to evaluate the evolution of this approach over the years,its potential oncologic benefits and potential risks,and the improvements offered by laparoscopic techniques.Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin(CVL)which guarantees removal of a larger number of lymph nodes.The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery,providing the same oncologic results as open surgery.This has been widely applied to colorectal cancer surgery;however,CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzesresults of these procedures in terms of oncological outcomes, technical feasibilityand complexity, especially within the context of minimally invasive surgery. | Marzia Franceschilli Sara Di Carlo Danilo Vinci Bruno Sensi Leandro Siragusa Vittoria Bellato Roberto Caronna Piero Rossi Giuseppe Cavallaro Andrea Guida Simone Sibio | 2021 | World Journal of Clinical Cases2021，9，25： | 2 |
| 8 | Cooling performance of earth-to-air heat exchangers applied to a poultry barn in semi-desert areas of south Iraq显示文摘Earth-to-air heat exchangers(EAHE)can reduce the energy consumption required for heating and cooling of buildings.The composition and the thermal characteristics of the soil influence the heat exchange capacity,and the soil moisture can furthermore affect thermal performance of EAHE.The aim of this study was to compare the thermal performance of EAHE in dry and artificially wetted soil.Tests were carried out in the Basra Province(Iraq),in a semi-desert area.Two experimental EAHE were built in a poultry barn and tested from June 2013 to September 2013.The pipe exchangers were buried at 2 m deep.One heat exchanger operated in dry soil(DE),while the other one operated in artificially wetted soil(WE).In the WE system,a drip tubing placed 10 cm above the air pipe wetted the soil around the exchanger.Air temperatures at the inlet and at the outlet of both the exchangers as well as soil temperature at 2 m deep were continuously monitored.The experimental results confirmed that wetting the soil around EAHE improves the general heat exchange efficiency.The coefficient of cooling performance(COP)of the earth-to-air heat exchangers system was evaluated on the basis of the ratio between the heat removed from the air or added to the air and the energy input.During the day,with an average COP of 6.41,the WE system cooled the air more than the DE system,which reported a value of 5.07.On average,in the hottest hours of the day,the outlet temperature of the WE was 37.35℃ while in the DE it was 38.91℃.Moreover,during the nighttime,the WE system warmed the air more than the DE system. | Wasseem Morshed Lorenzo Leso Leonardo Conti Giuseppe Rossi Stefano Simonini Matteo Barbari | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 2 |
| 9 | Percutaneous Laser Ablation in the Treatment of Hepatocellular Carcinoma with Small Tumors: Analysis of Factors Affecting the Achievement of Tumor Necrosis显示文摘 | Claudio Maurizio Pacella Giancarlo Bizzarri Giampiero Francica Antonio Bianchini Stefano De Nuntis Sara Pacella Anna Crescenzi Silvia Taccogna Giuseppe Forlini Zaccaria Rossi John Osborn Roberto Stasi | 2005 | Journal of Vascular and Interventional Radiology2005，，11： | 1 |
| 10 | Cirrhosis of the liver显示文摘 | Dr. Fabio Fornari MD Giuseppe Civardi MD Elisabetta Buscarini MD Luigi Cavanna MD Davide Imberti MD Sandro Rossi MD Giorgio Sbolli MD Michele Stasi MD Luigi Buscarini MD | 1990 | Digestive Diseases and Sciences1990，，11： | 1 |
| 11 | Subacute combined degeneration of the spinal cord in a vegan显示文摘 | Anna De Rosa Fabiana Rossi Maria Lieto Roberto Bruno Amalia De Renzo Vincenzo Palma Mario Quarantelli Giuseppe De Michele | 2012 | Clinical Neurology and Neurosurgery2012，，7： | 1 |
| 12 | Magnetic resonance imaging differential diagnosis of brainstem lesions in children显示文摘Differential diagnosis of brainstem lesions,either isolated or in association with cerebellar and supra-tentorial lesions,can be challenging. Knowledge of the structural organization is crucial for the differential diagnosis and establishment of prognosis of pathologies with involvement of the brainstem. Familiarity with the location of the lesions in the brainstem is essential,especially in the pediatric population. Magnetic resonance imaging(MRI) is the most sensitive and specific imaging technique for diagnosing disorders of the posterior fossa and,particularly,the brainstem. High magnetic static field MRI allows detailed visualization of the morphology,signal intensity and metabolic content of the brainstem nuclei,together with visualization of the normal development and myelination. In this pictorial essay we review the brainstem pathology in pediatric patients and consider the MR imaging patterns that may help the radiologist to differentiate among vascular,toxico-metabolic,infectiveinflammatory,degenerative and neoplastic processes. Helpful MR tips can guide the differential diagnosis: These include the location and morphology of lesions,the brainstem vascularization territories,gray and white matter distribution and tissue selective vulnerability. | Carlo Cosimo Quattrocchi Yuri Errante Maria Camilla Rossi Espagnet Stefania Galassi Sabino Walter Della Sala Bruno Bernardi Giuseppe Fariello Daniela Longo | 2016 | World Journal of Radiology2016，8，1： | 1 |
| 13 | Lipoprotein-associated phospholipase A2 single-nucleotide polymorphisms and cardiovascular events in patients with coronary artery disease显示文摘 | Giuseppe Maiolino Livia Lenzini Luigi Pedon Maurizio Cesari Teresa Maria Seccia Anna Chiara Frigo Giacomo Rossitto Brasilina Caroccia Gian Paolo Rossi | 2015 | Journal of Cardiovascular Medicine2015，，1： | 1 |
| 14 | A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III–IV endometriosis显示文摘 | Giuseppe Loverro Carmine Carriero A. Cristina Rossi Giuseppe Putignano Vittorio Nicolardi Luigi Selvaggi | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 1 |
| 15 | The current role of cardiac resynchronization therapy in reducing mortality and hospitalization in heart failure patients: a meta-analysis from clinical trials显示文摘 | Andrea Rossi Giuseppe Rossi Marcello Piacenti Umberto Startari Luca Panchetti Maria-Aurora Morales | 2008 | Heart and Vessels2008，，4： | 1 |
| 16 | Circulating microRNA changes in heart failure patients treated with cardiac resynchronization therapy: responders vs. non-responders显示文摘 | Raffaele Marfella Clara Di Filippo Nicoletta Potenza Celestino Sardu Maria Rosaria Rizzo Mario Siniscalchi Emilio Musacchio Michelangela Barbieri Ciro Mauro Nicola Mosca Francesco Solimene Maria Teresa Mottola Aniello Russo Francesco Rossi Giuseppe Paolis | 2013 | European Journal of Heart Failure2013，，： | 1 |
| 17 | Percutaneous Liver Biopsy Using an Ultrasound-Guided Subcostal Route显示文摘 | Piero Rossi Pierpaolo Sileri Paolo Gentileschi Giuseppe S. Sica Antonio Forlini Vito M. Stolfi Adriano De Majo Giorgio Coscarella Silvia Canale Achille L. Gaspari | 2001 | Digestive Diseases and Sciences2001，，1： | 1 |
| 18 | Early Detection of Relapse by Prospective Reverse Transcr-iptase-Polymerase Chain Reaction Analysis of the PML/RARα Fusion Gene in Patients With Acute Promyelocytic Le-ukemia Enrolled in the GIMEMA-AIEOP Multicenter 'AIDA' Trial显示文摘 | Daniela Diverio Vincenzo Rossi Giuseppe Avvisati | 1998 | Blood1998，92，3： | 1 |
| 19 | Role of the N Terminus in Enzyme Activity, Stability and Specificity in Thermophilic Esterases Belonging to the HSL Family显示文摘 | Luigi Mandrich Luigia Merone Margherita Pezzullo Laura Cipolla Francesco Nicotra Mosè Rossi Giuseppe Manco | 2004 | Journal of Molecular Biology2004，，3： | 1 |
| 20 | Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus显示文摘 | Pompea Vecchio Mikael Elias Luigia Merone Giuseppe Graziano Jér?me Dupuy Luigi Mandrich Paola Carullo Bertrand Fournier Daniel Rochu Mosè Rossi Patrick Masson Eric Chabriere Giuseppe Manco | 2009 | Extremophiles2009，，3： | 1 |
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