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| 1 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 2 | Retrospective Comparison of External Beam Radiotherapy and Radical Prostatectomy in High-Risk, Clinically Localized Prostate Cancer显示文摘 | Giorgio Arcangeli Lidia Strigari Stefano Arcangeli Maria Grazia Petrongari Biancamaria Saracino Sara Gomellini Rocco Papalia Giuseppe Simone Piero De Carli Michele Gallucci | 2009 | International Journal of Radiation Oncology Biology Physics2009，，4： | 1 |
| 3 | Measuring quality of life in dyspeptic patients: development and validation of a new specific health status questionnaire显示文摘 | Francesco Bamfi M.S Antonio Olivieri Fabio Arpinelli Gianfranco De Carli Giuseppe Recchia Lionello Gandolfi Lorenzo Norberto Franco Pacini Calogero Surrenti Sidney H Irvine Giovanni Apolone | 1999 | The American Journal of Gastroenterology1999，，3： | 1 |
| 4 | Impact of Proto-Oncogene Mutation Detection in Cytological Specimens from Thyroid Nodules Improves the Diagnostic Accuracy of Cytology显示文摘 | Silvia Cantara Marco Capezzone Stefania Marchisotta Serena Capuano Giulia Busonero Paolo Toti Andrea Di Santo Giuseppe Caruso Anton Ferdinando Carli Lucia Brilli Annalisa Montanaro Furio Pacini | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，： | 1 |
| 5 | Energy analysis of a wood or pellet stove in a single-family house equipped with gas boiler and radiators显示文摘In the residential sector,biomass appliances are widely used for space heating and often combined with other systems.This work aims at comparing the final and primary energy consumption of different configurations,including a conventional and a ducted pellet stove and a wood log stove using air as heat transfer fluid.A dynamic analysis of the interaction between biomass stoves and conventional heating systems,such as gas boilers and radiators,is carried out within a typical single-family house in a mild climate,using TRNSYS software.In addition,natural ventilation of the building is considered using CONTAM,with a focus on external infiltrations and internal air circulation due to the buoyancy effect.Results show that the biomass device in one room promotes the airflows between adjacent thermal zones,enhancing the heat distribution through door openings,in particular when an air ducted stove is present.The final energy consumption resulting from simulations with wood-burning stoves is 21%higher than pellet stoves.The pellet stove results in similar final energy and a 30%increase in overall primary energy,while the wood stove increases the final energy by 22%and approximately 40%of overall primary energy compared to the case of a traditional gas system coupled to radiators which is considered as reference.Nevertheless,non-renewable primary energy savings are higher than 50%with pellet stoves and 60%with wood-log stoves. | Marco Marigo Fabio Zulli Sara Bordignon Laura Carnieletto Giuseppe Emmi Michele De Carli | 2022 | Building Simulation2022，15，9： | 0 |
| 6 | Paraparesis induced by extramedullary haematopoiesis显示文摘We describe a case of worsening paraparesis induced by spinal cord compression at T6-T7 levels associated with compensatory extramedullary haematopoiesis from a compound heterozygote for haemoglobin E and for β-thalassemia.An emergency T3-T9 laminectomy was performed with excision of the masses and complete rehabilitation of the patient. | Paolo Savini Arianna Lanzi Giorgio Marano Chiara Carli Moretti Giovanni Poletti Giuseppe Musardo Francesco Giuseppe Foschi Giuseppe Francesco Stefanini | 2011 | World Journal of Radiology2011，3，3： | 0 |
| 7 | Potential of GSHP coupled with PV systems for retrofitting urban areas in different European climates based on archetypes definition显示文摘According to the recent policies regarding energy use in buildings and the need of retrofit strategies,the aim of this work is to support policies concerning the installation of ground source heat exchangers in urban and historical areas,raising the awareness on the potential energy saving achievable with optimal sizing and limited impact on the urban environment.Archetypes have been developed distinguishing among existing and historic buildings,focusing on single-family terrace houses,which are the typical residential buildings in European historic centres.A methodology for the optimal sizing of ground source heat pumps,eventually considering dual-source system or air system has been developed combining simulations of a photovoltaic system to estimate the self-sufficiency and the self-consumption for five orientations of the building.Extreme results have been obtained for warm cli-mates,with negligible heating energy demand and possibly free cooling systems rather than traditional cooling systems needed in wintertime.Penalty temperature was acceptable despite unbalanced energy demands.With proper inclination,photovoltaic systems could provide up to 40%of self-sufficiency share also in northern cli-mates.An energy-economic analysis was carried out obtaining a variety of cases representing a general overview of the European building stock and the potential benefits achievable in terms of renewable energy share,energy savings and economic investments needed to be extended to simulations at urban scale. | Laura Carnieletto Antonino Di Bella Davide Quaggiotto Giuseppe Emmi Adriana Bernardi Michele De Carli | 2024 | Energy and Built Environment2024，5，3： | 0 |
| 8 | Antiviral therapy of hepatitis C as curative treatment of indolent B-cell lymphoma显示文摘The association of hepatitis C virus(HCV) and B-cell non-Hodgkin lymphomas(NHL) has been highlighted by several epidemiological and biological insights; however the most convincing evidence is represented by interventional studies demonstrating the capability of antiviral treatment(AT) with interferon(IFN) with or without ribavirin to induce the regression of indolent lymphomas, especially of marginal-zone origin. In the largest published retrospective study(100 patients) the overall response rate(ORR) after first-line IFN-based AT was 77%(44% complete responses) and responses were sustainable(median duration of response 33 mo). These results were confirmed by a recent metaanalysis on 254 patients, demonstrating an ORR of 73%. Moreover this analysis confirmed the highly significant correlation between the achievement of viral eradication sustained virological response(SVR) and hematological responses. Two large prospective studies demonstrated that AT is associated with improved survival and argue in favor of current guidelines' recommendation of AT as preferential first-line option in asymptomatic patients with HCV-associated indolent NHL. The recently approved direct-acting antiviral agents(DAAs) revolutionized the treatment of HCV infection, leading to SVR approaching 100% in all genotypes. Very preliminary data of IFN-free DAAs therapy in indolent HCV-positive NHL seem to confirm their activity in inducing lymphoma regression. | Michele Merli Giuseppe Carli Luca Arcaini Carlo Visco | 2016 | World Journal of Gastroenterology2016，22，38： | 0 |
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