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| 1 | Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage显示文摘AIM To describe magnetic resonance(MR) imaging features of pancreatic neuroendocrine neoplasms(Pan NENs) according to their grade and tumor-nodes-metastases stage by comparing them to histopathology and todetermine the accuracy of MR imaging features in predicting their biological behavior.METHODS This study was approved by our institutional review board; requirement for informed patient consent was waived due to the retrospective nature of the study. Preoperative MR examinations of 55 Pan NEN patients(29 men, 26 women; mean age of 57.6 years, range 21-83 years) performed between June 2013 and December 2015 were reviewed. Qualitative and quantitative features were compared between tumor grades and stages determined by histopathological analysis.RESULTS Ill defined margins were more common in G2-3 and stage Ⅲ-Ⅳ PanN ENs than in G1 and low-stage tumors(P < 0.001); this feature had high specificity in the identification of G2-3 and stage Ⅲ-Ⅳ tumors(90.3% and 96%, 95%CI: 73.1-97.5 and 77.7-99.8). The mean apparent diffusion coefficient value was significantly lower in G2-3 and stage Ⅲ-Ⅳ lesions compared to well differentiated and low-stage tumors(1.09 × 10-3 mm2/s vs 1.45 × 10-3 mm2/s and 1.10 × 10-3 mm2/s vs 1.53 × 10-3 mm2/s, P = 0.003 and 0.001). Receiving operator characteristic analysis determined optimal cutoffs of 1.21 and 1.28 × 10-3 mm2/s for the identification of G2-3 and stage Ⅲ-Ⅳ tumors, with sensitivity and specificity values of 70.8/80.7% and 64.5/64%(95%CI: 48.7-86.6/60-92.7 and 45.4-80.2/42.6-81.3).CONCLUSION MR features of PanN ENs vary according to their grade of differentiation and their stage at diagnosis and could predict the biological behavior of these tumors. | Riccardo De Robertis Sara Cingarlini Paolo Tinazzi Martini Silvia Ortolani Giovanni Butturini Luca Landoni Paolo Regi Roberto Girelli Paola Capelli Stefano Gobbo Giampaolo Tortora Aldo Scarpa Paolo Pederzoli Mirko D'Onofrio | 2017 | World Journal of Gastroenterology2017,23,2: | 16 |
| 2 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 9 |
| 3 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 6 |
| 4 | Early Versus Late Drain Removal After Standard Pancreatic Resections: Results of a Prospective Randomized Trial显示文摘 | Claudio Bassi Enrico Molinari Giuseppe Malleo Stefano Crippa Giovanni Butturini Roberto Salvia Giorgio Talamini Paolo Pederzoli | 2010 | Annals of Surgery2010,,2: | 5 |
| 5 | Comparison of imaging-based and pathological dimensions in pancreatic neuroendocrine tumors显示文摘AIM To establish the ability of magnetic resonance(MR) and computer tomography(CT) to predict pathologic dimensions of pancreatic neuroendocrine tumors(Pan NET) in a caseload of a tertiary referral center.METHODS Patients submitted to surgery for Pan NET at the Surgical Unit of the Pancreas Institute with at least 1 preoperative imaging examination(MR or CT scan) from January 2005 to December 2015 were included and data retrospectively collected. Exclusion criteria were: multifocal lesions, genetic syndromes, microadenomas or mixed tumors, metastatic disease and neoadjuvant therapy. Bland-Altman(BA) and Mountain-Plot(MP) statistics were used to compare size measured by each modality with the pathology size. Passing-Bablok(PB) regression analysis was used to check the agreement between MR and CT.RESULTS Our study population consisted of 292 patients. Seventy-nine(27.1%) were functioning Pan NET. The mean biases were 0.17 ± 7.99 mm, 1 ± 8.51 mm and 0.23 ± 9 mm, 1.2 ± 9.8 mm for MR and CT, considering the overall population and the subgroup of non-functioning-Pan NET, respectively. Limits of agreement(LOA) included the vast majority of observations, indicating a good agreement between imaging and pathology. The MP further confirmed this finding and showed that the two methods are unbiased with respect to each other. Considering ≤ 2 cm non-functioning-Pan NET, no statistical significance was found in the size estimation rate of MR and CT(P = 0.433). PBR analysis did not reveal significant differences between MR, CT and pathology.CONCLUSION MR and CT scan are accurate and interchangeable imaging techniques in predicting pathologic dimensions of Pan NET. | Salvatore Paiella Harmony Impellizzeri Elisabetta Zanolin Giovanni Marchegiani Marco Miotto Anna Malpaga Riccardo De Robertis Mirko D'Onofrio Borislav Rusev Paola Capelli Sara Cingarlini Giovanni Butturini Maria Vittoria Davì Antonio Amodio Claudio BassiAldo Scarpa Roberto Salvia Luca Landoni | 2017 | World Journal of Gastroenterology2017,23,17: | 4 |
| 6 | Pancreatic fistula: definition and current problems显示文摘 | Giovanni Butturini Despoina Daskalaki Enrico Molinari Filippo Scopelliti Andrea Casarotto Claudio Bassi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008,,3: | 3 |
| 7 | Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas显示文摘 | Marco Dal Molin Hanno Matthaei Jian Wu Amanda Blackford Marija Debeljak Neda Rezaee Christopher L. Wolfgang Giovanni Butturini Roberto Salvia Claudio Bassi Michael G. Goggins Kenneth W. Kinzler Bert Vogelstein James R. Eshleman Ralph H. Hruban Anirban Mai | 2013 | Annals of Surgical Oncology2013,,12: | 2 |
| 8 | Pancreatic fistula: definition and current problems显示文摘 | Giovanni Butturini Despoina Daskalaki Enrico Molinari Filippo Scopelliti Andrea Casarotto Claudio Bassi | 2008 | Journal of Hepato - Biliary - Pancreatic Surgery2008,,3: | 1 |
| 9 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 1 |
| 10 | Duct-to-mucosa versus end-to-side pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: results of a prospective randomized trial显示文摘 | Claudio Bassi Massimo Falconi Enrico Molinari William Mantovani Giovanni Butturini Andrew A Gumbs Roberto Salvia Paolo Pederzoli | 2003 | Surgery2003,,5: | 1 |
| 11 | Clinical implications of biological markers in pancreatic ductal adenocarcinoma显示文摘 | Francesco Giovinazzo Giulia Turri Sara Zanini Giovanni Butturini Aldo Scarpa Claudio Bassi | 2012 | Surgical Oncology2012,,4: | 1 |
| 12 | Comp- lications after pancreaticoduodenectomy: the problem of current definitions显示文摘 | Giovanni Butturini Stefano Marcucci Enrico Molinari | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006,13,3: | 1 |
| 13 | Pancreatic fistula: definition and current problems显示文摘 | Giovanni Butturini Despoina Daskalaki Enrico Molinari Filippo Scopelliti Andrea Casarotto Claudio Bassi | 2008 | Journal of Hepato-Biliary-Pancreatic Surgery2008,,3: | 1 |
| 14 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 1 |
| 15 | The value of standard serum tumor markers in differentiating mucinous from serous cystic tumors of the pancreas: CEA, Ca 19-9, Ca 125, Ca 15-3显示文摘 | Claudio Bassi Roberto Salvia Andrew A. Gumbs Giovanni Butturini Massimo Falconi Paolo Pederzoli | 2002 | Langenbeck’s Archives of Surgery (-)2002,,7: | 1 |
| 16 | Perioperative management of patients undergoing pancreatic resection: Implementation of a care plan in a tertiary‐care center显示文摘 | Roberto Salvia Giuseppe Malleo Giovanni Butturini Marco Dal Molin Alessandro Esposito Giovanni Marchegiani Salvatore Paiella Anna Malpaga Martina Fontana Beatrice Personi Claudio Bassi | 2012 | J Surg Oncol2012,,1: | 1 |
| 17 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 1 |
| 18 | Pancreaticojejunostomy after pancreaticoduodenectomy: Suture material and incidence of post-operative pancreatic fistula显示文摘 | Stefano Andrianello Antonio Pea Alessandra Pulvirenti Valentina Allegrini Giovanni Marchegiani Giuseppe Malleo Giovanni Butturini Roberto Salvia Claudio Bassi | 2015 | Pancreatology2015,,: | 1 |
| 19 | Postoperative pancreatic fistula: An international study group (ISGPF) definition显示文摘 | Claudio Bassi Christos Dervenis Giovanni Butturini Abe Fingerhut Charles Yeo Jakob Izbicki John Neoptolemos Michael Sarr William Traverso Marcus Buchler | 2005 | Surgery2005,,1: | 1 |
| 20 | Pancreatic resections for cystic neoplasms: From the surgeon’s presumption to the pathologist’s reality显示文摘 | Roberto Salvia Giuseppe Malleo Giovanni Marchegiani Silvia Pennacchio Salvatore Paiella Marina Paini Antonio Pea Giovanni Butturini Paolo Pederzoli Claudio Bassi | 2012 | Surgery2012,,3: | 1 |